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The Impaction of Exercise Training on Bone Mineral Density in Patients After Total Knee Arthroplasty

NCT ID: NCT02928562

Last Updated: 2017-11-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

110 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-10-01

Study Completion Date

2017-10-31

Brief Summary

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Rehabilitation after total knee arthroplasty (TKA) should consider control of postoperative pain and swelling, protection of the healing graft, restoration of full range of motion symmetric to the contralateral knee, strengthening of the muscles that stabilize the knee, hip, and trunk, enhancing neuromuscular control, and a gradual progression to functional activities that are required for return to the normal daily life. The effects of concomitant injuries and surgical procedures must also be considered in planning an individualized rehabilitation program. However, it is still unclear regarding the optimal exercise prescription after TKA. In the current study, the investigators plan to develop an exercise protocol and evaluate the result in a multidisciplinary approach, i.e. bone mineral density assessment. The exercise prescription consisted of cyclic exercise, aerobic exercise and resistant training exercise for first, second and third year, respectively. Cyclic exercise is advantaged safety and effectiveness of hydraulic resistance equipment, as well as the exercise can be quantitatively determined. Aerobic exercise is privileged by the cardiopulmonary endurance improvement, along with muscle strengthening in the associated muscle groups. Resistance exercise is specified for the indicated muscle groups, especially knee extensors, flexors, ankle plantar flexor and dorsi flexor in TKA reconstructed patients. The investigators hypothesis that using this cyclic exercise process can improve the body composition, muscle strength, bone mass density, level of oxidative damage indicators, gait performance, quality of life, knee joint range of motion, function of cardiopulmonary and fitness. This project will establish the scientific basis for rehabilitation protocol involving knee surgery.

Detailed Description

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Conditions

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Knee Osteoarthritis Arthropathy of Knee

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Investigators Outcome Assessors

Study Groups

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Control

TKA patients without exercise intervention

Group Type NO_INTERVENTION

No interventions assigned to this group

Exercise

TKA patients with exercise intervention ( cyclic exercise, aerobic exercise and resistant training exercise )

Group Type EXPERIMENTAL

exercise

Intervention Type OTHER

cyclic exercise, aerobic exercise and resistant training exercise

Interventions

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exercise

cyclic exercise, aerobic exercise and resistant training exercise

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

Inclusion Criteria:

* The inclusion criteria of this study were the patients diagnosed with serious osteoarthritis (OA) and recommended to receive TKA surgery.

Exclusion Criteria:

* The exclusion criteria were the patients with Diabetes, Neuromusculoskeletal disorder, severe chronic disease, history of fracture of a lower limb, artificial limb, and unsuitable for exercise training
Minimum Eligible Age

65 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Chang Gung Memorial Hospital

OTHER

Sponsor Role lead

Responsible Party

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Robert Wen-Wei Hsu

Honorary Dean

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Robert Wen-Wei HSU, MD

Role: PRINCIPAL_INVESTIGATOR

Sports Medicine Center, Chang Gung Memorial Hospital, Chiayi

Locations

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Sports Medicine Center, Chang Gung Memorial Hospital

Chiayi City, , Taiwan

Site Status

Countries

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Taiwan

References

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Hsu WH, Hsu WB, Shen WJ, Lin ZR, Chang SH, Hsu RW. Circuit training enhances function in patients undergoing total knee arthroplasty: a retrospective cohort study. J Orthop Surg Res. 2017 Oct 19;12(1):156. doi: 10.1186/s13018-017-0654-4.

Reference Type DERIVED
PMID: 29052519 (View on PubMed)

Other Identifiers

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CORPG6C0021-23

Identifier Type: -

Identifier Source: org_study_id