Continuous Glucose Monitoring During Diets That Differ in Glycemic Load

NCT ID: NCT02926118

Last Updated: 2017-10-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

23 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-04-27

Study Completion Date

2017-10-18

Brief Summary

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This study test whether a Continuous Glucose Monitor can pickup differences in glucose (in the interstitial fluid) during a dietary intervention using meals with either a high with a low glycemic load.

Detailed Description

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The aim of this study is to determine the suitability of a continuous glucose monitor to detect the impact of a dietary intervention on postprandial blood glucose levels in normal, healthy, free living subjects. We will compare a dietary intervention of meals with a high glycemic load (high post-meal blood glucose) versus meals with a low glycemic load (low post-meal blood glucose) in a cross-over study. In addition, the glucose profiles obtained both via venous blood sampling and via continuous glucose monitor following a standard carbohydrate load will be compared.

Conditions

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Glucose Metabolism Disorders

Keywords

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Glucose Continuous glucose monitor Glycemic load Dietary intervention

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Low glycemic load

Low glycemic load

Group Type EXPERIMENTAL

Low glycemic load

Intervention Type DIETARY_SUPPLEMENT

Low glycemic load diets will be consumed at breakfast, lunch and dinner for three consecutive days

High glycemic load

High glycemic load

Group Type EXPERIMENTAL

High glycemic load

Intervention Type DIETARY_SUPPLEMENT

High glycemic load diets will be consumed at breakfast, lunch and dinner for three consecutive days

Interventions

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Low glycemic load

Low glycemic load diets will be consumed at breakfast, lunch and dinner for three consecutive days

Intervention Type DIETARY_SUPPLEMENT

High glycemic load

High glycemic load diets will be consumed at breakfast, lunch and dinner for three consecutive days

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Apparently healthy males and post-menopausal females
* Age at start of the study ≥ 50 and ≤ 70 years
* Body mass index (BMI) ≥ 25.0 and ≤ 35.0 kg/m2
* Fasting blood glucose value of subjects is ≥ 3.4 and \< 6.1 mmol/L at screening
* Being used to eat three meals a day
* Having a general practitioner
* Agreeing to be informed about medically relevant personal test-results by a physician
* Accessible veins on arms as determined by examination at screening.

Exclusion Criteria

* Having a medical conditions which might affect the study measurements (including but not limited to: diabetes type 1 and type 2, gastrointestinal disorders, gastrointestinal surgery and inflammatory diseases, as judged by the study physician
* Reported use of over-the-counter or prescribed medication or food supplements, which may interfere with study measurements as judged by the principal investigator
* Use of oral antibiotics in 40 days or less prior to the start of the study
* Reported participation in another nutritional or biomedical study 3 months before the screening or during the study
* Reported participation in night shift work 2 weeks prior to screening or during the study. Night work is defined as working between mid-night and 6.00 am
* Reported intense sporting activities \> 2h/w. Intense sporting activities are defined as those activities that cause a lack of breath which limits the ability to have a normal conversation
* Reported alcohol consumption \> 10 units/week (female) or \> 14 units/week (male)
* Reported use of any nicotine containing products in the 6 months preceding the study and willing to abstain from use of nicotine containing products during the study itself
* Reported dietary habits: medically prescribed diet, slimming diet, vegetarian
* Reported weight loss/gain (\> 3 kg) in the last 2 months before the study
* Being an employee of Unilever or research departments in NUTRIM or the Maastricht University Medical Centre (MUMC+) collaborating in this study
* Known allergy or intolerance to food products.
* Blood donation in the past 3 months
Minimum Eligible Age

50 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Maastricht University

OTHER

Sponsor Role collaborator

Unilever R&D

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Mensink Ronald P, PhD

Role: PRINCIPAL_INVESTIGATOR

Maastricht University

Locations

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Maastricht University

Maastricht, , Netherlands

Site Status

Countries

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Netherlands

Other Identifiers

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REF-CSC-2682

Identifier Type: -

Identifier Source: org_study_id