Trial Outcomes & Findings for Improving Neuromuscular Monitoring and Reducing Residual Neuromuscular Blockade Via E-learning (NCT NCT02925143)

Results Overview

Number of Participants Who Received a Depolarizing Neuromuscular Blocking Agent (NMBA) (Succinylcholine) and was Monitored with Objective Neuromuscular Monitoring (Acceleromyography). Data on neuromuscular monitoring is automatically registered in the electronic patient chart when the equipment for acceleromyography is activated.

Recruitment status

COMPLETED

Study phase

NA

Target enrollment

6525 participants

Primary outcome timeframe

in the period from induction of anaesthesia to termination of anaesthesia, usually 2 hours

Results posted on

2021-05-18

Participant Flow

Participant milestones

Participant milestones
Measure	E-learning Course E-learning course in neuromuscular monitoring: An e-learning course designed to assess the challenges and common problems experienced by anesthetists when monitoring the neuromuscular blockade during general anesthesia.
Overall Study STARTED	6525
Overall Study Participants Receiving Depolarizing Neuromuscular Blocking Agent (NMBA) (Succinylcholine)	3099
Overall Study Participants Receiving Non-depolarizing Neuromuscular Blocking Agent (NMBA)	3426
Overall Study COMPLETED	6525
Overall Study NOT COMPLETED	0

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Race and Ethnicity were not collected from any participant.

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	E-learning Course n=6525 Participants E-learning course in neuromuscular monitoring: An e-learning course designed to assess the challenges and common problems experienced by anesthetists when monitoring the neuromuscular blockade during general anesthesia.
Age, Continuous	57.8 years STANDARD_DEVIATION 19.3 • n=6525 Participants
Sex: Female, Male Female	3597 Participants n=6525 Participants
Sex: Female, Male Male	2928 Participants n=6525 Participants
Region of Enrollment Denmark	6525 participants n=6525 Participants

PRIMARY outcome

Timeframe: in the period from induction of anaesthesia to termination of anaesthesia, usually 2 hours

Population: Only patients who received a Depolarizing Neuromuscular Blocking Agent (NMBA) (Succinylcholine) are analyzed in this outcome.

Number of Participants Who Received a Depolarizing Neuromuscular Blocking Agent (NMBA) (Succinylcholine) and was Monitored with Objective Neuromuscular Monitoring (Acceleromyography). Data on neuromuscular monitoring is automatically registered in the electronic patient chart when the equipment for acceleromyography is activated.

Outcome measures

Outcome measures
Measure	E-learning Course n=3099 Participants E-learning course in neuromuscular monitoring: An e-learning course designed to assess the challenges and common problems experienced by anesthetists when monitoring the neuromuscular blockade during general anesthesia.
Application of Objective Neuromuscular Monitoring (Acceleromyography) in Cases Receiving a Depolarizing Neuromuscular Blocking Agent (NMBA) (Succinylcholine) (Yes/no)	1425 Participants

PRIMARY outcome

Timeframe: in the period from induction of anaesthesia to termination of anaesthesia, usually 2 hours

Population: Only patients receiving a non-depolarizing neuromuscular blocking agent are analyzed in this outcome

Number of Participants Who Received a Non-depolarizing Neuromuscular Blocking Agent (NMBA) and was Monitored with Objective Neuromuscular Monitoring (Acceleromyography). Data on neuromuscular monitoring is automatically registered in the electronic patient chart when the equipment for acceleromyography is activated.

Outcome measures

Outcome measures
Measure	E-learning Course n=3426 Participants E-learning course in neuromuscular monitoring: An e-learning course designed to assess the challenges and common problems experienced by anesthetists when monitoring the neuromuscular blockade during general anesthesia.
Application of Objective Neuromuscular Monitoring (Acceleromyography) in Cases Receiving a Non-depolarizing NMBA (Yes/no)	3172 Participants

SECONDARY outcome

Timeframe: in the period from induction of anaesthesia to termination of anaesthesia, usually 2 hours]

Population: Only patients receiving a non-depolarizing neuromuscular blocking agent, monitored with acceleromyography and with a valid TOF ratio in the last three measurements are included in this outcome.

The Train-of-four (TOF) ratio is the ratio of the fourth to the first muscle response after 4 stimuli at the ulnar nerve at the wrist at 2 Hz. The response is measured using acceleromyography. If the last measurement is performed before return of any muscle function, the ration can not be given.

Outcome measures

Outcome measures
Measure	E-learning Course n=3027 Participants E-learning course in neuromuscular monitoring: An e-learning course designed to assess the challenges and common problems experienced by anesthetists when monitoring the neuromuscular blockade during general anesthesia.
Last Recorded Train-of-four (TOF) Ratio Before Tracheal Extubation or Removal of Supraglottic Airway Device in Patients Receiving a Non-depolarizing NMBA	95.23 ratio Standard Deviation 29.57

SECONDARY outcome

Timeframe: in the period from induction of anaesthesia to discharge from the post-anaesthesia care unit, usually 5 hours

Population: Only patients receiving a non-depolarizing neuromuscular blocking agent are analyzed in this outcome.

If the total dose of sugammadex in the anaesthesia information management system is \> 0, the outcome is "yes".

Outcome measures

Outcome measures
Measure	E-learning Course n=3426 Participants E-learning course in neuromuscular monitoring: An e-learning course designed to assess the challenges and common problems experienced by anesthetists when monitoring the neuromuscular blockade during general anesthesia.
Administration of Sugammadex in Cases Receiving a Non-depolarizing NMBA (Yes/no)	85 Participants

SECONDARY outcome

Timeframe: in the period from induction of anaesthesia to discharge from the post-anaesthesia care unit, usually 5 hours

Population: Only patients receiving a non-depolarizing neuromuscular blocking agent are analyzed in this outcome.

If the total dose of neostigmine in the anaesthesia information management system is \> 0, the outcome is "yes".

Outcome measures

Outcome measures
Measure	E-learning Course n=3426 Participants E-learning course in neuromuscular monitoring: An e-learning course designed to assess the challenges and common problems experienced by anesthetists when monitoring the neuromuscular blockade during general anesthesia.
Administration of Neostigmine in Cases Receiving a Non-depolarizing NMBA (Yes/no)	2047 Participants

SECONDARY outcome

Timeframe: in the period from induction of anaesthesia to discharge from the post-anaesthesia care unit, usually 5 hours

Population: Only patients receiving a non-depolarizing neuromuscular blocking agent are analyzed in this outcome.

If the total dose of neostigmine is bigger than (\>) the first dose administered, the outcome is "yes".

Outcome measures

Outcome measures
Measure	E-learning Course n=3426 Participants E-learning course in neuromuscular monitoring: An e-learning course designed to assess the challenges and common problems experienced by anesthetists when monitoring the neuromuscular blockade during general anesthesia.
Administration of More Than One Reversal Agent in Cases Receiving a Non-depolarizing NMBA (Yes/no)	213 Participants

SECONDARY outcome

Timeframe: in the period from induction of anaesthesia to discharge from the post-anaesthesia care unit, usually 180 minutes

Population: Only patients receiving a non-depolarizing neuromuscular blocking agent with data on length-of-stay in the post-anaesthesia care unit are analyzed in this outcome.

Outcome measures

Outcome measures
Measure	E-learning Course n=2533 Participants E-learning course in neuromuscular monitoring: An e-learning course designed to assess the challenges and common problems experienced by anesthetists when monitoring the neuromuscular blockade during general anesthesia.
Time in Minutes From Tracheal Extubation or Removal of Supraglottic Airway Device to Discharge From Post-anaesthesia Care Unit in Cases Involving a Non-depolarizing NMBA	100 minutes Interval 1.0 to 1431.0

Adverse Events

E-learning Course

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Dr. Jakob Thomsen

Herlev Hospital

Phone: 004538683868

Email: [email protected]

Results disclosure agreements

Principal investigator is a sponsor employee
Publication restrictions are in place