Mobile Health Behavioral Intervention in Patients With Heart Failure and Diabetes Mellitus

NCT ID: NCT02918175

Last Updated: 2020-11-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

187 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-08-02

Study Completion Date

2020-09-09

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The overall objective of this study is to test a personalized mHealth intervention designed to increase physical activity and improve medication adherence in subjects with heart failure and diabetes mellitus. The study will leverage consumer technology as both an intervention and as a tool for data collection.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

This is a multi-center randomized controlled study in eligible subjects with heart failure and diabetes mellitus. Step counts, self-reported quality of life, medication adherence, blood samples and relevant clinical measures will be collected from all study subjects. The mobile health (mHealth) intervention will combine personalized text messages to encourage physical activity and a medication adherence teaching tool. A total of approximately 200 eligible subjects will be randomized in in a 1:1 ratio to either mHealth intervention + usual care/data collection or the control group (usual care/data collection only). The study duration is 6 months for all subjects; those in the intervention group will receive the mHealth intervention during the initial 3 months followed by 3 months of data collection only. The underlying hypotheses is that the proposed mHealth intervention can favorably impact specific health behaviors (physical activity and medication adherence) and physiologic measures of disease status for both heart failure and diabetes. Additional hypotheses to be tested will assess the persistence of behavioral changes (daily physical activity and medication adherence) and physiologic measures (NT-proBNP, HbA1c) beyond the 3-month time point of the active mHealth intervention (i.e. through 6 months).

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Diabetes Mellitus Heart Failure

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

mHealth Intervention

Subjects in this study arm will have data on activity levels, quality of life, medication adherence, and blood samples collected. In addition, they will receive personalized feedback on activity goals based on prior week step counts and participate in coaching sessions using the Pillbox medication tool.

Group Type OTHER

mHealth

Intervention Type BEHAVIORAL

Personalized step count feedback and medication teaching tool.

No intervention

Subjects in this study arm will have data on activity levels, quality of life, medication adherence, and blood samples collected.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

mHealth

Personalized step count feedback and medication teaching tool.

Intervention Type BEHAVIORAL

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Feedback on step counts Duke PillBox medication adherence teaching tool

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* ≥ 18 years of age
* Chronic heart failure, New York Heart Association (NYHA) class II-IV, with ongoing treatment with medications for heart failure for at least 1 month prior to enrollment
* Prior diabetes mellitus diagnosis, with ongoing treatment with anti-diabetes medications for at least 1 month prior to enrollment
* Adequate clinical stability in the judgment of the investigator to allow participation in study assessments and the intervention
* Independent with basic activities of daily living (ADLs), including the ability to ambulate independently
* No plan for revascularization (cardiac or peripheral), outpatient continuous intravenous inotrope administration, cardiac transplant or ventricular assist device implantation, or other cardiac surgery within 6 months of randomization
* Access to a compatible smart phone (iOS or Android)
* Signed informed consent

Exclusion Criteria

* Acute myocardial infarction within prior 4 weeks
* Already actively participating in formal, facility-based cardiac rehabilitation
* Severe stenotic valvular disease (e.g., severe aortic stenosis)
* Implanted left ventricular assist device (LVAD)
* Recipient of a heart transplant
* Terminal illness other than heart failure with life expectancy \< 6 months
* Impairment from stroke, injury or other medical disorder that precludes participation in the intervention
* Inability or unwillingness to comply with the study requirements
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Duke Clinical Research Institute

OTHER

Sponsor Role collaborator

American Heart Association

OTHER

Sponsor Role collaborator

Duke University

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Gary M Felker, MD

Role: PRINCIPAL_INVESTIGATOR

Duke University Medical Center/Duke Clinical Research Institute

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Stanford University School of Medicine

Stanford, California, United States

Site Status

Massachusetts General Hospital

Boston, Massachusetts, United States

Site Status

NewYork-Presbyterian Brooklyn Methodist Hospital

Brooklyn, New York, United States

Site Status

Duke University Medical Center

Durham, North Carolina, United States

Site Status

University of Texas Southwestern Medical Center

Dallas, Texas, United States

Site Status

Inova Health System

Fairfax, Virginia, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

16SFRN30740010

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

Pro00075572

Identifier Type: -

Identifier Source: org_study_id