Environmental Exposure and Neurological Diseases Questionnaire

NCT ID: NCT02916966

Last Updated: 2024-05-01

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 460 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2016-10-31
• Study Completion Date: 2023-09-30

Brief Summary

The proposed research is particularly relevant to the National ALS Registry and public environmental health issues because it addresses the potential environmental causes of sporadic ALS. The research will develop an ALS surveillance program in Ohio that can be compared with the national and State-Metro Surveillance Programs of the National ALS Registry, and novel methodologies to determine the role of the cyanobacterial toxin, BMAA (beta-methylamino-L-alanine), and other environmental toxins/toxicants as risk factors for ALS. This work will advance the mission of the Centers for Disease Control Agency for Toxic Substances and Disease Registry (CDC ATSDR) National ALS Registry by offering data on ALS cases in Ohio that address public health concerns over the effects of chronic exposure to cyanobacterial blooms in Lake Erie.

Conditions

Amyotrophic Lateral Sclerosis

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Study Groups

ALS Patients in Case-Control

ALS patients enrolled by Cleveland Clinic Foundation (CCF)

Patient Registry

Intervention Type: OTHER

Patient Registry

Non-neurodegenerative patients in case control

Non-neurodegenerative patients enrolled by CCF

Patient Registry

Intervention Type: OTHER

Patient Registry

Non-neurodegeneration population in population control

Non-neurodegenerative general population enrolled by ABS mailing system from DHMC

Patient Registry

Intervention Type: OTHER

Patient Registry

ALS Patients in State of OH

ALS registry of all cases in Ohio

Patient Registry

Intervention Type: OTHER

Patient Registry

Interventions

Patient Registry

Patient Registry

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• ALS
• Non-neurodegenerative controls
• Can willingly give consent
• Over 18 years of age

Exclusion Criteria

• Cannot give consent
• Under 18 years of age

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

The Cleveland Clinic

OTHER

Sponsor Role: collaborator

Dartmouth-Hitchcock Medical Center

OTHER

Sponsor Role: lead

Responsible Party

Elijah W. Stommel

Professor of Neurology

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Cleveland Clinic Foundation

Cleveland, Ohio, United States

Countries

United States

Other Identifiers

D06019

Identifier Type: -

Identifier Source: org_study_id