IRDye800CW-BBN PET-NIRF Imaging Guiding Surgery in Patients With Glioblastoma
NCT ID: NCT02910804
Last Updated: 2018-01-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
EARLY_PHASE1
30 participants
INTERVENTIONAL
2015-11-30
2018-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
DIAGNOSTIC
NONE
Study Groups
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68Ga-BBN-IRDye800CW PET/NIRF
The patients were injected with 40μg/111-148 Mega-Becquerel (MBq) 68Ga-BBN-IRDye800CW in one dose intravenously and then underwent PET scan 30 min later before the operation and intraoperative 1.0 mg/ml BBN-IRDye800CW injected intravenously for near-infrared (NIR) fluorescent imaging-guided surgery.
68Ga-BBN-IRDye800CW
PET/NIRF
PET/NIR fluorescent imaging-guided surgery
Interventions
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68Ga-BBN-IRDye800CW
PET/NIRF
PET/NIR fluorescent imaging-guided surgery
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* MRI imaging and/or pathological evidence of Newly Diagnosed or recurrence GBM
Exclusion Criteria
* Severe liver or kidney disease with serum creatinine \> 3.0 mg/dl (270 μΜ)
* Any hepatic enzyme level 5 times or more than normal upper limit
* Severe allergy or hypersensitivity to IV radiographic contrast
* Claustrophobia to accept the PET/CT scanning
* Pregnancy or breast feeding
18 Years
70 Years
ALL
Yes
Sponsors
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Peking Union Medical College Hospital
OTHER
National Institute for Biomedical Imaging and Bioengineering (NIBIB)
NIH
Chinese Academy of Sciences
OTHER_GOV
Beijing Tiantan Hospital
OTHER
Responsible Party
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Deling Li
Dr.
Principal Investigators
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Nan Ji, MD
Role: STUDY_DIRECTOR
Beijing Tiantan Hospital, Capital Medical University Beijing 100050, China
Zhaohui Zhu, MD.
Role: STUDY_DIRECTOR
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Locations
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Beijing Tiantan Hospital, Capital Medical University
Beijing, Beijing Municipality, China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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BTHospital-N-005
Identifier Type: -
Identifier Source: org_study_id
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