Fulvestrant 500mg in Patients With Advanced Breast Cancer

NCT ID: NCT02909361

Last Updated: 2022-04-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-10-11

Study Completion Date

2022-10-31

Brief Summary

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Fulvestrant 500mg in Patients With Advanced Breast Cancer

Detailed Description

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A multicenter, prospective study real-world to evaluate the safety profile and effectiveness in Chinese patients who received Fulvestrant 500mg as first-line endocrine treatment for Advanced breast cancer

Conditions

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Metastatic Breast Cancer

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Fulvestrant

500 mg on days 0, 14, and 28, and every 28 days thereafter

Fulvestrant

Intervention Type DRUG

500 mg on days 0, 14, and 28, and every 28 days thereafter

Interventions

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Fulvestrant

500 mg on days 0, 14, and 28, and every 28 days thereafter

Intervention Type DRUG

Other Intervention Names

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Fulvestrant Injection

Eligibility Criteria

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Inclusion Criteria

1. Chinese women with estrogen receptor positive, locally advanced or metastatic breast cancer who has already received Fulvestant 500mg treatment as determined by treating physician. Ovarian suppression in premenopausal women is permitted, including ovarian ablation and LHRHa.
2. Histologically confirmed positive oestrogen receptor status (ER positive) of primary breast cancer or metastatic tumour tissue, according to the local laboratory parameters.
3. Prior endocrine therapy for advanced disease was not permitted.
4. The prescription of the Fulvestant is clearly separated from the decision to include the subject in the NIS, and is part of normal medical practice. The recruitment of the patient to the study should be within 1 month of the first Fulvestant injection.
5. Provision of subject informed consent.

Exclusion Criteria

1. If participating in any controlled clinical trial, the subject cannot take part in this study.
2. HER2 overexpression or gene amplification, ie, immunohistochemistry (IHC) 3+ or fluorescence in situ hybridisation (FISH)+, where appropriate.
3. Pervious regimen of endocrine therapy for advanced disease.
4. More than one regimen of chemotherapy for advanced disease.
5. Pregnancy and lactation.
6. Severe hepatic impairment.
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Fudan University

OTHER

Sponsor Role lead

Responsible Party

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Xichun Hu

Director of department of medical oncology

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Xichun Hu, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Fudan University

Locations

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Fudan University Cancer Hospital

Shanghai, , China

Site Status

Countries

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China

Other Identifiers

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Fudan BR2016-21

Identifier Type: -

Identifier Source: org_study_id

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