Validation Study of mHealth Technology in HIV to Improve Empowerment and Healthcare Utilisation: Research and Innovation to Generate Evidence for Personalised Care (EmERGE)

NCT ID: NCT02904733

Last Updated: 2017-12-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

3900 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-04-07

Study Completion Date

2019-09-30

Brief Summary

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A large (3900 patients) cohort study, undertaken in five European sites to validate in a mHealth platform to enable self-management of HIV in patients with stable disease using a tailored HTA process, Model for Assessment of Telemedicine Applications (MAST), specifically developed for the assessment of mHealth solutions.

As site recruitment will be sequential and the recruitment period will last 18 months, a maximum follow-up of 35 Months will be undertaken. Study visits will take place at baseline defined as the time of mHealth introduction, months 6, 12, 18, 24 and 30.

Detailed Description

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Number of Study Centres: 5 Duration of Study: 35 Months Criteria for Evaluation: Usability of the mHealth platform, patient self-management and empowerment, clinical safety (virological suppression maintenance, CD4 count, laboratory parameters, adverse events and adherence), quality of life and self-economy will be assessed by questionnaires and laboratory parameters.

Routine data on patient demographics, treatment and investigations which will include viral load, CD4, haematology, biochemistry and urine sample. Patient Activation Measure, Quality of life, adherence questionnaire and economic questionnaires will be performed at baseline and at months 12 and 24. Satisfaction System Usability Scale will be evaluated at month 12 and 24.

Conditions

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HIV Infections

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

HEALTH_SERVICES_RESEARCH

Blinding Strategy

NONE

Study Groups

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mHealth platform

Stable HIV-1 infected subjects will be followed-up using an mHealth platform. The platform will provide users with web based and mobile device applications which interface securely with relevant medical data and facilitate remote access to healthcare providers. The minimum length of follow-up will be 12 months and the maximum 35 months.

Group Type EXPERIMENTAL

mHealth platform

Intervention Type OTHER

Use of a mHealth platform to inform and empower patient of hies/her own health

Interventions

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mHealth platform

Use of a mHealth platform to inform and empower patient of hies/her own health

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Documented HIV-1 infection
2. Aged at least 18 years old
3. Able to give informed consent
4. In possession of a smartphone, tablet, or similar technology supporting the mHealth platform
5. Stable on ART: Defined as ART should be unchanged for at least 3 months and viral load undetectable (\<50 copies/ml) for at least 6 months.
6. Clinically stable from an HIV perspective: Defined as without opportunistic infection or AIDS related cancers within the previous 12 months

Exclusion Criteria

1. Aged less than 18 years
2. Pregnant
3. Participating in a clinical trial or receiving an investigational medication
4. Unable to comprehend the patient information sheet
5. Unable to comprehend the instructions for using the mHealth platform
6. Considered for any other reason by their regular physician to be unsuitable for study participation.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Brighton and Sussex University Hospitals NHS Trust

OTHER

Sponsor Role collaborator

Instituut Voor Tropische Geneeskunde (ITM), Antwerp, Belgium.

UNKNOWN

Sponsor Role collaborator

Klinika za infektivne bolesti (KIB), Zagreb, Croatia

UNKNOWN

Sponsor Role collaborator

Centro Hospitalar de Lisboa Central

OTHER

Sponsor Role collaborator

Fundacion Clinic per a la Recerca Biomédica

OTHER

Sponsor Role collaborator

University of Brighton

OTHER

Sponsor Role collaborator

Podmedics, ( POD), Northwood, United Kingdom

UNKNOWN

Sponsor Role collaborator

Universidad Politecnica de Madrid

OTHER

Sponsor Role collaborator

National Prospective Monitoring System HIV Health-economics Collaboration, (NPMS), Richmond, United Kingdom

UNKNOWN

Sponsor Role collaborator

European Aids Treatment Group (EATG), Brussels, Belgium

UNKNOWN

Sponsor Role collaborator

mHealth Futures LTD, Brighton, United Kingdom

UNKNOWN

Sponsor Role collaborator

Hospital Clinic of Barcelona

OTHER

Sponsor Role lead

Responsible Party

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Agathe LEON

Dr

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Prins Leopold Instituut Voor Tropische Geneeskunde

Antwerp, , Belgium

Site Status RECRUITING

Klinika za Infektivne Bolesti Dr. Fran Mihaljevic

Zagreb, , Croatia

Site Status RECRUITING

Centro Hospitalar de Lisboa Central

Lisbon, , Portugal

Site Status RECRUITING

Hospital Clínic i Provincial

Barcelona, , Spain

Site Status RECRUITING

University of Brighton

Brighton, , United Kingdom

Site Status RECRUITING

Countries

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Belgium Croatia Portugal Spain United Kingdom

Central Contacts

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Jennifer Whetham, MD

Role: CONTACT

Phone: +44 1273 523081

Email: [email protected]

Agathe León, MD

Role: CONTACT

Phone: +34932275400

Email: [email protected]

Facility Contacts

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Ludgiw Aspers, MD

Role: primary

Josip Begovac, MD

Role: primary

Eugenio Teofilo, MD

Role: primary

Agathe Leon, MD

Role: primary

Eva González, MD

Role: backup

Jennifer Whetham, MD

Role: primary

Other Identifiers

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EMERGE

Identifier Type: -

Identifier Source: org_study_id