Mass Balance Study of MT-3995

NCT ID: NCT02900235

Last Updated: 2017-01-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

9 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-08-31

Study Completion Date

2016-12-31

Brief Summary

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The purpose of this study is to investigate the absorption, metabolism and excretion of MT-3995 in healthy subjects.

Detailed Description

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Conditions

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Healthy

Keywords

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Healthy

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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MT-3995

\[14C\]-MT-3995 after a single oral dose

Group Type EXPERIMENTAL

MT-3995

Intervention Type DRUG

Interventions

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MT-3995

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Able to provide written informed consent to participate in the study
* Caucasian male aged at least 35 years at Screening
* Healthy and free from clinically significant illness or disease at Screening and Day-1
* A body weight of 60 to 110 kg at Screening and Day-1
* Vital signs within the following ranges at Screening, Day-1 and Pre-dose:

* Body temperature : 35.0°C to 37.5°C
* Systolic blood pressure: 90 to 140 mmHg
* Diastolic blood pressure: 50 to 90 mmHg
* Regular daily bowel movements

Exclusion Criteria

* Presence or history of severe adverse reaction or allergy to any medicinal product
* Participation in more than three clinical studies of an Investigational Medicinal Product (IMP) in the previous year or participated in a clinical study of any IMP within 12 weeks or five half-lives
* Any surgical or medical condition which might significantly alter the absorption, distribution, metabolism or excretion of drugs or which may jeopardise the subject in case of participation in the study. The Investigator should be guided by evidence of any of the following:

* History of inflammatory bowel syndrome, gastritis, ulcers, gastrointestinal or rectal bleeding considered clinically significant by the Investigator
* History of major gastrointestinal tract surgery such as gastrectomy, gastroenterostomy or bowel resection
* History or clinical evidence of pancreatic injury or pancreatitis
Minimum Eligible Age

35 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Mitsubishi Tanabe Pharma Corporation

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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General Manager

Role: STUDY_DIRECTOR

Mitsubishi Tanabe Pharma Corporation

Locations

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Investigational center

City Name, , United Kingdom

Site Status

Countries

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United Kingdom

Other Identifiers

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MT-3995-E11

Identifier Type: -

Identifier Source: org_study_id