Joint Pain Occurring During Anti-TNF Therapy in Chronic Inflammatory Bowel Disease

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

99 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-09-30

Study Completion Date

2016-10-31

Brief Summary

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IBD (inflammatory bowel disease) are associated with various types of joint manifestations, especially inflammatory. Patients with IBD treated with anti-TNF commonly report joint symptoms, with variable expressions and aetiologies, possibly responsible for impaired quality of life, and possibly leading to discontinuation of an effective and validated treatment.

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Detailed Description

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Conditions

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Inflammatory Bowel Diseases

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Control

patients treated with anti-TNF not presenting any joint symptoms.

diagnosis of joint

Intervention Type OTHER

The diagnosis of joint pain will be established by a rheumatologist and completed:

* If necessary, by a clinically guided radiological assessment (plain x-rays, joint ultrasound, bone and joint MRI).
* serum assays of the anti-TNF administered, as well as screening for associated antibodies.

case

aetiology of joint symptoms

diagnosis of joint

Intervention Type OTHER

The diagnosis of joint pain will be established by a rheumatologist and completed:

* If necessary, by a clinically guided radiological assessment (plain x-rays, joint ultrasound, bone and joint MRI).
* serum assays of the anti-TNF administered, as well as screening for associated antibodies.

Interventions

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diagnosis of joint

The diagnosis of joint pain will be established by a rheumatologist and completed:

* If necessary, by a clinically guided radiological assessment (plain x-rays, joint ultrasound, bone and joint MRI).
* serum assays of the anti-TNF administered, as well as screening for associated antibodies.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Males or females over the age of 18 years at the time of inclusion
* Patients with IBD (Crohn's disease or ulcerative colitis), diagnosed by a set of compatible clinical (chronic diarrhoea, haematochezia, anoperineal lesions, etc.), laboratory, histological and endoscopic arguments. Patients will be included regardless of the severity of their disease, its clinical course, the type of lesions, and the presence or absence of associated manifestations.
* Patients treated with anti-TNF: infliximab or adalimumab.
* Informed patients not refusing to participate.
* Patients covered by French national health insurance.

Exclusion Criteria

* Patients under the age of 18 years at the time of inclusion.
* Patients previously treated with anti-TNF, but no longer treated with anti-TNF at the time of inclusion.
* Protected majors (under permanent or temporary guardianship).

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No