Trial Outcomes & Findings for Rates of Recovery From Strenuous Exercise in Physically Active Older Adults (NCT NCT02899650)
NCT ID: NCT02899650
Last Updated: 2021-01-22
Results Overview
Rate of force development are measured by determining peak torque achieved on an isometric leg extension machine.
TERMINATED
NA
60 participants
After the downhill running protocol, various markers of muscle damage and muscular strength were obtained 24 hours post (the third visit), 48 hours post (the forth visit) and 72 hours post (the fifth visit).
2021-01-22
Participant Flow
We planned to recruit a total of 60 participants. However, we were not able to recruit older unfit adults so this group was dropped from the study. Additionally, this was a research project conducted by a visiting scholar and his departure approached quickly so the study was closed prematurely with smaller numbers in each group.
Participant milestones
| Measure |
Young Fit
Young (18-39 yrs) people who have endurance training habit
|
Young Unfit
Young (18-39 yrs) people who have sedentary lifestyle
|
Older Fit
Older (50-80 yrs) people who have endurance training habit
|
Older Unfit
Older (50-80 yrs) people who have sedentary lifestyle
|
|---|---|---|---|---|
|
Overall Study
STARTED
|
15
|
10
|
14
|
0
|
|
Overall Study
COMPLETED
|
15
|
10
|
14
|
0
|
|
Overall Study
NOT COMPLETED
|
0
|
0
|
0
|
0
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
Rates of Recovery From Strenuous Exercise in Physically Active Older Adults
Baseline characteristics by cohort
| Measure |
Young Fit
n=15 Participants
Young (18-39 yrs) people who have endurance training habit
|
Young Unfit
n=10 Participants
Young (18-39 yrs) people who have sedentary lifestyle
|
Older Fit
n=14 Participants
Older (50-80 yrs) people who have endurance training habit
|
Total
n=39 Participants
Total of all reporting groups
|
|---|---|---|---|---|
|
Age, Continuous
Age
|
27 years
STANDARD_DEVIATION 2 • n=5 Participants
|
28 years
STANDARD_DEVIATION 2 • n=7 Participants
|
58 years
STANDARD_DEVIATION 2 • n=5 Participants
|
38 years
STANDARD_DEVIATION 2 • n=4 Participants
|
|
Sex: Female, Male
Female
|
5 Participants
n=5 Participants
|
6 Participants
n=7 Participants
|
8 Participants
n=5 Participants
|
19 Participants
n=4 Participants
|
|
Sex: Female, Male
Male
|
10 Participants
n=5 Participants
|
4 Participants
n=7 Participants
|
6 Participants
n=5 Participants
|
20 Participants
n=4 Participants
|
|
Ethnicity (NIH/OMB)
Hispanic or Latino
|
1 Participants
n=5 Participants
|
0 Participants
n=7 Participants
|
1 Participants
n=5 Participants
|
2 Participants
n=4 Participants
|
|
Ethnicity (NIH/OMB)
Not Hispanic or Latino
|
14 Participants
n=5 Participants
|
10 Participants
n=7 Participants
|
13 Participants
n=5 Participants
|
37 Participants
n=4 Participants
|
|
Ethnicity (NIH/OMB)
Unknown or Not Reported
|
0 Participants
n=5 Participants
|
0 Participants
n=7 Participants
|
0 Participants
n=5 Participants
|
0 Participants
n=4 Participants
|
PRIMARY outcome
Timeframe: After the downhill running protocol, various markers of muscle damage and muscular strength were obtained 24 hours post (the third visit), 48 hours post (the forth visit) and 72 hours post (the fifth visit).Rate of force development are measured by determining peak torque achieved on an isometric leg extension machine.
Outcome measures
| Measure |
Young Fit
n=15 Participants
Young (18-39 yrs) people who have endurance training habit
exercise: acute downhill running
|
Young Unfit
n=10 Participants
Young (18-39 yrs) people who have sedentary lifestyle.
exercise: acute downhill running
|
Older Fit
n=14 Participants
Older (50-80 yrs) people who have endurance training habit
exercise: acute downhill running
|
|---|---|---|---|
|
Rate of Force Development
Baseline
|
102 Nm
Standard Error 3
|
108 Nm
Standard Error 4
|
100 Nm
Standard Error 2
|
|
Rate of Force Development
24h post
|
97 Nm
Standard Error 3
|
106 Nm
Standard Error 4
|
100 Nm
Standard Error 3
|
|
Rate of Force Development
48h post
|
100 Nm
Standard Error 2
|
106 Nm
Standard Error 5
|
103 Nm
Standard Error 3
|
|
Rate of Force Development
72h post
|
102 Nm
Standard Error 2
|
105 Nm
Standard Error 4
|
103 Nm
Standard Error 2
|
SECONDARY outcome
Timeframe: After the downhill running protocol, muscle damage pain scale was measured 24 hours post (the third visit), 48 hours post (the forth visit) and 72 hours post (the fifth visit).Pain scale on quadriceps muscle was assessed using a validated visual pain scale. The scale was on a 10-point scale (0 being absence of soreness, 10 being worst imaginable soreness).
Outcome measures
| Measure |
Young Fit
n=15 Participants
Young (18-39 yrs) people who have endurance training habit
exercise: acute downhill running
|
Young Unfit
n=10 Participants
Young (18-39 yrs) people who have sedentary lifestyle.
exercise: acute downhill running
|
Older Fit
n=14 Participants
Older (50-80 yrs) people who have endurance training habit
exercise: acute downhill running
|
|---|---|---|---|
|
Pain Scale
72h post
|
2.7 arbitrary scale unit from 0 to 10
Standard Error 0.5
|
3.2 arbitrary scale unit from 0 to 10
Standard Error 0.8
|
1.5 arbitrary scale unit from 0 to 10
Standard Error 0.4
|
|
Pain Scale
Baseline
|
0.2 arbitrary scale unit from 0 to 10
Standard Error 0.1
|
0.1 arbitrary scale unit from 0 to 10
Standard Error 0.1
|
0.0 arbitrary scale unit from 0 to 10
Standard Error 0.0
|
|
Pain Scale
24h post
|
3.7 arbitrary scale unit from 0 to 10
Standard Error 0.5
|
4.7 arbitrary scale unit from 0 to 10
Standard Error 0.6
|
2.4 arbitrary scale unit from 0 to 10
Standard Error 0.6
|
|
Pain Scale
48h post
|
4.2 arbitrary scale unit from 0 to 10
Standard Error 0.6
|
4.9 arbitrary scale unit from 0 to 10
Standard Error 0.7
|
2.7 arbitrary scale unit from 0 to 10
Standard Error 0.6
|
Adverse Events
Young Fit
Young Unfit
Older Fit
Older Unfit
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place