tDCS Effect on Cognitive Functions From Patients With Alzheimer's Disease or Progressive Primary Aphasia
NCT ID: NCT02873546
Last Updated: 2017-10-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
52 participants
INTERVENTIONAL
2013-07-19
2018-07-31
Brief Summary
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After unblinding, patients who received placebo treatment could be received active tDCS.
Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
TRIPLE
Study Groups
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anodal tDCS on left DLPFC (F3)
tDCS is a non-invasive neuromodulation method, which delivers a constant current of low intensity (1 mA) during 30 minutes for 10 sessions. Anode is placed on the scalp facing on left DLPFC (F3) and cathode between Fp2-F8 EEG-repair.
transcranial Direct Current Stimulation (tDCS)
After locating the stimulation areas, treatment will be delivered during 30-minute session. Treatment will be occur 2 session per day during 5 consecutive days. Subjects will be monitored during tDCS sessions for any side effects or adverse events.
sham tDCS on left DLPFC (F3)
Sham tDCS differs from active tDCS by the interruption of stimulation after 15 sec and reactivation of the stimulation 15 sec before the end of the session (30 minutes - 10 sessions. Anode is placed on the scalp facing on left DLPFC (F3) and cathode between Fp2-F8 EEG-repair.
transcranial Direct Current Stimulation (tDCS)
After locating the stimulation areas, treatment will be delivered during 30-minute session. Treatment will be occur 2 session per day during 5 consecutive days. Subjects will be monitored during tDCS sessions for any side effects or adverse events.
Interventions
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transcranial Direct Current Stimulation (tDCS)
After locating the stimulation areas, treatment will be delivered during 30-minute session. Treatment will be occur 2 session per day during 5 consecutive days. Subjects will be monitored during tDCS sessions for any side effects or adverse events.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* CDR score ≤ 2
* treatment by IAChE ≥ 3 months
* MADRS score \< 18
* w/o severe progressive somatic pathology (especially tumor diseases)
Exclusion Criteria
* presence of a specific contraindication for tDCS (e.g. personal history of epilepsy, metallic head implant, cardiac pacemaker)
60 Years
ALL
No
Sponsors
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Centre Hospitalier Universitaire Dijon
OTHER
Assistance Publique - Hôpitaux de Paris
OTHER
Centre Hospitalier Universitaire de Besancon
OTHER
Responsible Party
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Principal Investigators
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Claire Paquet, MD PhD
Role: PRINCIPAL_INVESTIGATOR
Assitance Publique - Hôpitaux Paris
Bernard Bonnin, MD PhD
Role: PRINCIPAL_INVESTIGATOR
Centre Hospitalier Universaitaire Dijon
Locations
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CHU Besancon - Clinical Psychiatric Department
Besançon, , France
Hopital Universitaire Dijon
Dijon, , France
Assistance Publique - Hôpitaux Paris
Paris, , France
Countries
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Central Contacts
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Facility Contacts
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Magali Nicolier, PhD
Role: primary
Bernard Bonnin, MD PhD
Role: primary
Hélène Francisque
Role: primary
Hélène Francisque
Role: backup
References
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Bereau M, Sylvestre G, Mauny F, Puyraveau M, Baudier F, Magnin E, Berger E, Vandel P, Galmiche J, Chopard G. [Assessment of 10 years of memory consultations in the Franche-Comte: Description and analysis of the RAPID regional database]. Rev Neurol (Paris). 2015 Sep;171(8-9):655-61. doi: 10.1016/j.neurol.2015.04.008. Epub 2015 Jul 23. French.
Other Identifiers
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API/2011/24
Identifier Type: -
Identifier Source: org_study_id