Use of Autologous Concentrated Bone Marrow Aspirate in Preventing Wound Complications in Below Knee Amputation (BKA)

NCT ID: NCT02863926

Last Updated: 2024-12-12

Study Results

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

6 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-01-06

Study Completion Date

2018-07-27

Brief Summary

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Patients scheduled for major extremity lower amputation to receive bone marrow cells (cBMA) injected IM in the leg proximal to the amputation in the index limb to prevent ischemic wound complications after surgery.

Detailed Description

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Patients scheduled for amputation will receive bone marrow cells concentrated via the MarrowStim device (cBMA) injected IM at 25 sites in the leg proximal to the amputation in the index limb to prevent ischemic wound complications after surgery. cBMA will be injected into the anterior tibialis muscle below the point of amputation in an area approximately 3cm\^2 x 2cm\^2 for analytical purposes. Patients will be scheduled for amputation at Days 7, 14, or 21 post injection. Safety will be evaluated by review of treatment related adverse events (AE) during the 52-week follow-up period. The investigator will compare rates of wound complications and amputation revisions to historical controls at the institution to assess trends in therapeutic efficacy.

Patients will undergo amputation and injection sites will be harvested at that time. Immunohistochemical staining (IHC) will determine capillary density and local host immune responses. Angiogenic and inflammatory cytokines will be quantified using a multiplex array system and quantitative polymerase chain reaction (PCR).

Conditions

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Peripheral Artery Disease Vascular Disease Critical Limb Ischemia

Keywords

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BKA amputation MarrowStim below knee amputation wound complication vascular disease critical limb ischemia peripheral artery disease AKA stem cells bone marrow

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Autologous bone marrow derived mesenchymal stromal cells will be delivered intramuscularly in the lower extremity of participants undergoing lower extremity major amputation to assess incidence of wound healing and infection prevention.
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Day 7

BKA performed at 7 days post autologous cBMA injection. Injection of cBMA aspirate into the index leg

Group Type EXPERIMENTAL

Injection of cBMA aspirate into the index leg

Intervention Type BIOLOGICAL

Injection of cBMA into the anterior tibialis muscle and upper index leg of subjects scheduled for semi-elective BKA 7-21 days before surgery

Day 14

BKA performed at 14 days post autologous cBMA injection. Injection of cBMA aspirate into the index leg

Group Type EXPERIMENTAL

Injection of cBMA aspirate into the index leg

Intervention Type BIOLOGICAL

Injection of cBMA into the anterior tibialis muscle and upper index leg of subjects scheduled for semi-elective BKA 7-21 days before surgery

Day 21

BKA performed at 21 days post autologous cBMA injection. Injection of cBMA aspirate into the index leg

Group Type EXPERIMENTAL

Injection of cBMA aspirate into the index leg

Intervention Type BIOLOGICAL

Injection of cBMA into the anterior tibialis muscle and upper index leg of subjects scheduled for semi-elective BKA 7-21 days before surgery

Interventions

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Injection of cBMA aspirate into the index leg

Injection of cBMA into the anterior tibialis muscle and upper index leg of subjects scheduled for semi-elective BKA 7-21 days before surgery

Intervention Type BIOLOGICAL

Other Intervention Names

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concentrated bone marrow cBMA

Eligibility Criteria

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Inclusion Criteria

1. Be ≥ 40 and ≤90 years of age.
2. Patients requiring below knee amputation, as determined by an independent vascular specialist.
3. If ulceration or gangrene present, it is distal to malleoli (to allow adequate length of ATM for 4 injections 4 cm. apart)
4. BKA can safely be performed up to 30 days after screening, as determined by an independent vascular or orthopedic surgeon. This information will be documented in subjects' case report forms (CRFs).
5. Females of childbearing potential must be willing to use one form of birth control for the duration of the study. Female participants must undergo a blood or urine pregnancy test at screening.

Exclusion Criteria

1. Patients who are pregnant, planning to become pregnant in the next 12 months, or lactating.
2. Significant hepatic dysfunction (ALT or AST greater than 2 times normal).
3. CHF hospitalization within the last 1 month prior to enrollment.\*
4. Acute coronary syndrome (ACS) in the last 1 month prior to enrollment.\*
5. HIV positive, or active, untreated HCV.
6. History of cancer within the last 5 years, except basal cell skin carcinoma
7. Any bleeding diathesis defined as an INR ≥ 2.0 (off anticoagulation therapy) or history of platelet count less than 70,000 or hemophilia.
8. Inability to provide written informed consent due to cognitive or language barriers (interpreter permitted).
9. Concurrent enrollment in another clinical investigative trial.
10. Any condition requiring immunosuppressant medications (e.g., for treatment of organ transplants, psoriasis, Crohn's disease, alopecia areata).
11. Presence of any clinical condition that in the opinion of the PI or the sponsor makes the patient not suitable to participate in the trial.

* As defined by the standard definitions of CHF and ACS by the American Heart Association.
Minimum Eligible Age

40 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Zimmer Biomet

INDUSTRY

Sponsor Role collaborator

Michael Murphy

OTHER

Sponsor Role lead

Responsible Party

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Michael Murphy

Principal Investigator, MD

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Michael P Murphy, MD

Role: PRINCIPAL_INVESTIGATOR

Indiana University

Locations

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Indiana University School of Medicine

Indianapolis, Indiana, United States

Site Status

Countries

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United States

References

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Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Document Type: Informed Consent Form

View Document

Other Identifiers

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1511774456

Identifier Type: -

Identifier Source: org_study_id