Pharmacogenetic and Antidepressant Treatment in Elderly

NCT ID: NCT02856477

Last Updated: 2016-08-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

28 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-11-30

Study Completion Date

2016-04-30

Brief Summary

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The study aims to assess the therapeutic benefits of the adaptation of the antidepressant dose to the metabolic capacity (cytochrome P450 2D6) of elderly depressed patients.

Therapeutic benefits are evaluated through the enhancement of efficiency, decrease of the action time and the after effects.

Detailed Description

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Conditions

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Depression

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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adapted treatment

the treatment dose is adapted to the metabolic capacity of the patient. intervention: urine analysis

Group Type EXPERIMENTAL

urine analysis

Intervention Type BIOLOGICAL

a sample of urine is collected during 8 hours.

non-adaptated treatment

the treatment dose is adapted to the metabolic capacity of the patient. intervention: urine analysis

Group Type EXPERIMENTAL

urine analysis

Intervention Type BIOLOGICAL

a sample of urine is collected during 8 hours.

Interventions

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urine analysis

a sample of urine is collected during 8 hours.

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* current major depressive disorder
* antidepressant treatment

Exclusion Criteria

* dextromethorphan contra-indication
* other psychiatric disorder
* kidney failure
* liver failure mini mental State Examination (MMSE)\<18
Minimum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Centre Hospitalier Universitaire de Besancon

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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pierre Vandel, MD PhD

Role: PRINCIPAL_INVESTIGATOR

Centre Hospitalier Universitaire de Besancon

Locations

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CHU Besancon

Besançon, Doubs, France

Site Status

Countries

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France

Other Identifiers

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R/2007/32

Identifier Type: -

Identifier Source: org_study_id

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