Chemotherapy-related Toxicity, Nutritional Status and Quality of Life

NCT ID: NCT02848807

Last Updated: 2016-07-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-09-30

Study Completion Date

2016-12-31

Brief Summary

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Determine whether nutritional support with high protein ONS in adult oncologic patients in the first step of cancer cachexia - asymptomatic precachexia, influence on the toxicity of systemic therapy.

Detailed Description

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Other endpoints:

* to determine whether high protein ONS influence on the nutritional status
* to determine whether high protein ONS influence on the quality of life
* to determine whether high protein ONS influence on the performance status
* to determine high protein ONS tolerability / ONS intake compliance

Conditions

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Toxicity Due to Chemotherapy Cancer Cachexia Metastatic Colorectal Cancer Quality of Life Dietary Modification

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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NUTRIDRINK Compact Protein

NUTRIDRINK Compact Protein Oral nutritional supplement Dietary advice

Group Type ACTIVE_COMPARATOR

NUTRIDRINK Compact Protein

Intervention Type DIETARY_SUPPLEMENT

high-energy, high-protein, oral liquid nutritional supplement; dosage: 2x125 ml per day, 7 days per week for 12 weeks (3 months)

without oral nutritional supplements

Dietary advice alone

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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NUTRIDRINK Compact Protein

high-energy, high-protein, oral liquid nutritional supplement; dosage: 2x125 ml per day, 7 days per week for 12 weeks (3 months)

Intervention Type DIETARY_SUPPLEMENT

Other Intervention Names

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Oral nutritional supplement

Eligibility Criteria

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Inclusion Criteria

* histological confirmed diagnosis of CRC in clinical stage IV
* successful qualification to chemotherapy
* performance status at least 80% according to Karnofsky scale and \<2 according to WHO/ECOG scale
* cancer-related asymptomatic precachexia diagnosed
* absence of contraindications to oral nutrition and practicable realization of oral nutrition
* absence of severe, decompensated concomitant diseases
* signed informed consent for the participation in the study

Exclusion Criteria

* diagnosis of a malignant neoplasm in clinical stage I-III
* disqualification from oncologic treatment
* cancer cachexia or cancer anorexia-cachexia syndrome
* poor performance status
* contraindications to oral nutrition or to high protein nutrition
* regular nutritional support at the moment of qualification to the study
* patient incompliance at the moment of qualification to the study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Nutricia Foundation

OTHER

Sponsor Role collaborator

University Clinical Centre, Gdansk

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Sylwia Malgorzewicz, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

University Clinical Centre, Gdansk, Poland

Locations

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University Clinical Centre

Gdansk, , Poland

Site Status RECRUITING

Countries

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Poland

Central Contacts

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Sylwia Malgorzewicz, MD, PhD

Role: CONTACT

Phone: +48 58 3492724

Email: [email protected]

Facility Contacts

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Sylwia Malgorzewicz, MD, PhD

Role: primary

Other Identifiers

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01/2014/UCK

Identifier Type: -

Identifier Source: org_study_id