Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE1
11 participants
INTERVENTIONAL
2013-10-31
2014-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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Sodium nitrate
Sodium nitrate will be administered orally and functional sympatholysis assessed before and after treatment
Sodium nitrate
Sodium nitrate will be ingested orally
Interventions
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Sodium nitrate
Sodium nitrate will be ingested orally
Eligibility Criteria
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Inclusion Criteria
* age 15-55 years of age
* ambulatory
Exclusion Criteria
* elevated brain natriuretic peptide level (\>100 pg/ml)
* Left ventricular ejection fraction \< 50%
* cardiac rhythm disorder, specifically: rhythm other than sinus, supraventricular tachycardia, atrial fibrillation, ventricular tachycardia, heart block
* continuous ventilatory support
* liver disease
* renal impairment
* history of asthma or bronchospasm
* use of any medications other than common supplements
* unable to perform handgrip exercise
15 Years
55 Years
MALE
Yes
Sponsors
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Cedars-Sinai Medical Center
OTHER
Responsible Party
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Ron Victor
Professor of Medicine
Principal Investigators
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Ronald G Victor, MD
Role: PRINCIPAL_INVESTIGATOR
Cedars-Sinai Medical Center
Locations
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Cedars-Sinai Heart Institute
Los Angeles, California, United States
Cedars-Sinai Medical Center
Los Angeles, California, United States
Countries
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References
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Martin EA, Barresi R, Byrne BJ, Tsimerinov EI, Scott BL, Walker AE, Gurudevan SV, Anene F, Elashoff RM, Thomas GD, Victor RG. Tadalafil alleviates muscle ischemia in patients with Becker muscular dystrophy. Sci Transl Med. 2012 Nov 28;4(162):162ra155. doi: 10.1126/scitranslmed.3004327.
Other Identifiers
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Pro00033300
Identifier Type: -
Identifier Source: org_study_id
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