The Use of Self-reported Symptoms as a Proxy for Acute Organophosphate Poisoning Among Nepali Farmers

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

42 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-09-30

Study Completion Date

2014-11-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to evaluate self-reported symptoms as a proxy for acute organophosphate poisoning by examining self-reported acute organophosphate poisoning symptoms and PchE activity in response to occupational acute organophosphate exposure among farmers in Nepal.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Farming, Personal Protective Equipment, Nepal

NCT02137317

Organophosphate Poisoning

COMPLETED NA

Organophosphate Pesticides and Human Reproductive Health

NCT00046124

Fecundability Spermatazoa Disorders Menstruation Disorders +1 more

COMPLETED

Pesticide Exposure Pathways for Farmworker Children

NCT00013754

Poisoning

COMPLETED

Incidence and Mortality of Childhood Cancer Among Children of Farmer Pesticide Applications

NCT00339378

Pesticide Exposure

COMPLETED

Effects of Pesticide Exposure on Neurodevelopment/Growth/Respiratory Health

NCT00021658

Environmental Exposure

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Organophosphate Poisoning

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Group A

Initial spray session: organophosphate. Crossover spray session: placebo

Group Type OTHER

Organophosphate

Intervention Type OTHER

Chlorpyrifos 50% plus cypermethrin 5%, WHO Class II: Moderately hazardous

Placebo

Intervention Type OTHER

Multineem, WHO Class U: Unlikely to present acute hazard in normal use

Group B

Initial spray session: placebo. Crossover spray session: organophosphate

Group Type OTHER

Organophosphate

Intervention Type OTHER

Chlorpyrifos 50% plus cypermethrin 5%, WHO Class II: Moderately hazardous

Placebo

Intervention Type OTHER

Multineem, WHO Class U: Unlikely to present acute hazard in normal use

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Organophosphate

Chlorpyrifos 50% plus cypermethrin 5%, WHO Class II: Moderately hazardous

Intervention Type OTHER

Placebo

Multineem, WHO Class U: Unlikely to present acute hazard in normal use

Intervention Type OTHER

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Biopesticide

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* male
* minimum age 18 years
* hand pressured backpack sprayer usage
* used to spray with moderately to extremely hazardous pesticides according to the World Health Organization's (WHO) Pesticide Hazard Classification

Exclusion Criteria

* usual personal protective equipment use (respirator/mask with particulate filter, face shield, googles, gloves, boots, plastic poncho)
* unwilling to stay pesticide-free seven days prior to each of the two spray sessions
* medical conditions interfering with PchE activity (liver disease, acute infection, chronic malnutrition, heart attack, cancer, obstructive jaundice, inflammation caused by various diseases, or use of pyridostigmine drugs)

Minimum Eligible Age

18 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes