Study to Characterize Acute and Chronic Directional Aspects of Deep Brain Stimulation

NCT ID: NCT02835274

Last Updated: 2020-11-19

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-07-19

Study Completion Date

2018-12-19

Brief Summary

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The primary objective is to characterize the programming effects of Boston Scientific Vercise™ PC System using the DBS Directional Lead for bilateral STN DBS for the treatment of Parkinson's disease in acute and chronic settings.

Detailed Description

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Conditions

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Parkinson Disease

Keywords

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parkinson disease deep brain stimulation directional stimulation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

OTHER

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Ring mode followed by Unrestricted mode

omni-directional stimulation followed by unrestricted Mode stimulation

Group Type EXPERIMENTAL

BSC Deep Brain Stimulation System with Directional Lead

Intervention Type DEVICE

Unrestricted mode followed by ring mode

Unrestricted Mode stimulation followed by omni-directional stimulation

Group Type ACTIVE_COMPARATOR

BSC Deep Brain Stimulation System with Directional Lead

Intervention Type DEVICE

Interventions

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BSC Deep Brain Stimulation System with Directional Lead

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of bilateral idiopathic PD with the presence of rigidity and at least one (1) of the following: resting tremor or bradykinesia.
* UPDRS III score of \>25 in the meds OFF condition
* Medication must improve PD symptoms by ≥30%, as measured by UPDRS subset III score

Exclusion Criteria

* Any significant psychiatric problems, including unrelated clinically significant depression as determined by the investigator
* Any current drug or alcohol abuse as determined by the investigator
* Any history of recurrent or unprovoked seizures
* Any significant medical condition that is likely to interfere with study procedures or likely to confound evaluation of study endpoints, including any terminal illness with survival \<12 months
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Boston Scientific Corporation

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Roshini Jain

Role: STUDY_DIRECTOR

Boston Scientific Neuromodulation Corporation

Locations

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CHU Grenoble - Hopital Michallon

Grenoble, , France

Site Status

Universitaetsklinikum Wuerzburg

Würzburg, , Germany

Site Status

Academisch Medisch Centrum

Amsterdam, , Netherlands

Site Status

Countries

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United States France Germany Netherlands

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

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A4150

Identifier Type: -

Identifier Source: org_study_id