Substance Use in Elderly Individuals: Brain and Cognitive Correlates and the Effect of Psychotherapy

NCT ID: NCT02835144

Last Updated: 2017-11-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-02-02

Study Completion Date

2017-11-15

Brief Summary

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The prevalence of addictive disorders in old age is increasing. Age specific and appropriate therapeutic concepts tailored to in-patients thus represent a promising approach for the future. The investigated therapeutic intervention is a "therapy program for integrated qualified acute treatment of alcohol and drug problems" (TIQAAM).

Detailed Description

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The prevalence of addictive disorders in old age is increasing. Age specific and appropriate therapeutic concepts tailored to inpatients thus represent a promising approach for the future. The investigated therapeutic intervention is a "therapy program for integrated qualified acute treatment of alcohol and drug problems" (TIQAAM).

Subjects ≥ 65 years, in which according to the WHO ASSIST V3.0 a risky consumption of alcoholic beverages, or benzodiazepines / non-benzodiazepine hypnotics (zolpidem, zopiclone, zaleplon), or both, are examined before and after a psychotherapeutic intervention during their inpatient stay exists. The data collected in part 1 of the study pertain to social integration, the motivation to change, quality of life in old age, general psychiatric symptoms. The data collected in part 2 of the study pertain to brain structure and functions. Data from standard procedures will be correlated to the data above.These relate to psychiatric symptoms, past consumption behavior, cognitive abilities, perceived social support and risk appetite.

Conditions

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Substance Use Disorder

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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TIQAAM_therapy

Individuals in this group will receive units from the TIQAAM treatment program

Group Type EXPERIMENTAL

TIQAAM_therapy

Intervention Type OTHER

The treatment program consists of TIQAAM therapy blocks to three priority areas: promoting change and motivation, relapse prevention and relapse management, and promote resource and euthymic activities to increase the abstinence motivation. The TIQAAM is based on behavioral approaches as well as motivational interviewing of Miller and Rollnick.

active_control

Individuals in this group will receive units of psychoeducation

Group Type ACTIVE_COMPARATOR

Psychoeducation

Intervention Type OTHER

This intervention is a psychoeducation module pertaining to substance use disorders.

Interventions

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TIQAAM_therapy

The treatment program consists of TIQAAM therapy blocks to three priority areas: promoting change and motivation, relapse prevention and relapse management, and promote resource and euthymic activities to increase the abstinence motivation. The TIQAAM is based on behavioral approaches as well as motivational interviewing of Miller and Rollnick.

Intervention Type OTHER

Psychoeducation

This intervention is a psychoeducation module pertaining to substance use disorders.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Subjects aged 65 or above with, according to WHO-ASSIST V3.0, a hazardous consumption of alcoholic beverages and / or benzodiazepines and / or non-benzodiazepine hypnotics (zolpidem, zopiclone, zaleplon)
* The subjects must be able to understand verbal and written information about the study flow and content and to give their written consent.
* The subjects must be able to understand and perform verbal and written tasks (cognitive tests / questionnaires)

Exclusion Criteria

* Taking medication that could affect cognition outside of benzodiazepines and / or non-benzodiazepine hypnotics (zolpidem, zopiclone, zaleplon).
* Drug treatments with anxiolytics (benzodiazepines) as part of an ongoing drug-assisted detoxification
* Taking antidepressant medication
* Taking sleep-inducing substances (for example Dipiperon®, Trittico®, Valverde Sleep® or Valverde Entspannung®)
* Taking other anxiolytic active substances (for example, pregabalin, Opipramol). The use of medication is allowed to treat somatic diseases.
* Use of drugs or substance dependence. Except for alcohol, benzodiazepines and non-benzodiazepine hypnotics (zolpidem, zopiclone, zaleplon)
* Diseases which prevent the subject from giving consent for this study or which impair cooperation in the investigation.
* Severe and / or unstable physical illness: severe depression, severe mania, delirium, severe cognitive impairment (mini-mental status test \< 20/30 points), dementia of the Alzheimer type or other dementias, multiple sclerosis, clinically manifest structural brain damage (eg cerebral hemorrhage, brain tumors, MRI findings by Schulthess clinic)
* Heavily impaired vision and eye diseases


* Pacemaker, implantable cardioverter defibrillator (ICD), neurostimulator, aneurysm clip, prosthetic heart valve, valve prosthesis, metal prosthesis
* Clips after surgery, metallic bone plates, artificial joints, metal fragments in the body, professional in the metal processing industry, non-removable piercing, ferruginous tattoo ink
* Pregnancy
* Claustrophobia
Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Prof. Dr. med. Egemen Savaskan

OTHER

Sponsor Role lead

Responsible Party

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Prof. Dr. med. Egemen Savaskan

Prof. Dr. med.

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Egemen Savaskan, Prof. Dr. med.

Role: PRINCIPAL_INVESTIGATOR

Klinik für Alterspsychiatrie

Locations

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Gerontopsychiatrisches Zentrum Hegibach

Zurich, , Switzerland

Site Status

Countries

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Switzerland

Other Identifiers

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KNVRKAS - 2016-00210

Identifier Type: -

Identifier Source: org_study_id