The Effect of Anesthetic Technique on VEGF-C and PGE2

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

44 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-05-31

Study Completion Date

2016-04-30

Brief Summary

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The purpose of this study is to verify the effect of anesthetic technique on the change of postoperative serum vascular endothelial growth factor C and prostaglandin E2, and to explore the potential impact of the anesthetic technique on leiomyomas recurrence and growth after the surgery of abdominal myomectomy.

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Detailed Description

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Uterine leiomyomas is the most common benign tumor of uterus, the most common tumor in women as well. Like many other forms of tumor, it requires an independent blood supply to enlarge. This process, angiogenesis, is mediated by vascular endothelial growth factor C (VEGF-C) and prostaglandin E2 (PGE2). Several studies have confirmed that VEGF-C has a high level in patients with uterine leiomyomas, which has also been demonstrated that it was related to occurrence and growth of uterine leiomyomas because it's capable of promoting angiogenesis, mitogenic, and vascular permeability-enhancing activities. Also, some researchers suggested that suppression of prostaglandin synthesis (including PGE2) via cyclooxygenase type-2 (COX-2) enzyme inhibition may reduce the incidence of some tumor. The aim of this study is to verify the effect of anesthetic technique on the change of postoperative serum VEGF-C and PGE2, and to explore the potential impact of the anesthetic technique on leiomyomas recurrence and growth after the surgery of abdominal myomectomy.

Conditions

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Uterine Leiomyomas

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Participants

Study Groups

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Group GA

22 patients receive general anesthesia and patient controlled intravenous analgesia

Group Type OTHER

general anesthesia and patient controlled intravenous analgesia

Intervention Type OTHER

Patients receive general anesthesia intraoperative period and continuous intravenous analgesia postoperation

Group SA

22 patients receive spinal anesthesia and continuous postoperative epidural analgesia

Group Type OTHER

spinal anesthesia and continuous postoperative epidural analgesia

Intervention Type OTHER

Patients receive spinal anesthesia intraoperative period and continuous epidural analgesia postoperation

Interventions

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general anesthesia and patient controlled intravenous analgesia

Patients receive general anesthesia intraoperative period and continuous intravenous analgesia postoperation

Intervention Type OTHER

spinal anesthesia and continuous postoperative epidural analgesia

Patients receive spinal anesthesia intraoperative period and continuous epidural analgesia postoperation

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* The patients with leiomyomas requiring abdominal myomectomy, aged 18-65 year and American Society of Anesthesiologists (ASA) physical status I or II.

Exclusion Criteria

* The patients who had a history of surgery within the preceding two weeks, a history of blood transfusion and a history of coronary artery disease, any contraindication to spinal anesthesia or opioid analgesia.

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No