CKD-396 Drug-drug Interaction Study(B) (CKD-396 DDI(B) P1)

NCT ID: NCT02827890

Last Updated: 2017-08-09

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 20 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-04-30
• Study Completion Date: 2016-05-31

Brief Summary

The purpose of this study is to evaluate a pharmacokinetic drug interaction between sitagliptin and lobeglitazone in healthy male volunteers.

Detailed Description

To healthy male subjects of twenty(20), following treatments are administered dosing in each period and wash-out period is a minimum of 10 days.

Conditions

Diabetes Mellitus Type 2

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Group 1(Treatment A/Treatment B)

Period 1: Treatment A(Januvia Tab. 100mg)*1T/day for 5 days, QD, PO.

Period 2: Treatment B(Januvia Tab. 100mg + Duvie Tab. 0.5mg)*1T/day for 5 dyas, QD, PO.

Each treatment period was separated by a washout period of at least 10 dyas.

Group Type: EXPERIMENTAL

Januvia Tab. 100mg

Intervention Type: DRUG

Januvia Tab. 100mg\*1T/day for 5days, QD, PO

Januvia Tab. 100mg + Duvie Tab. 0.5mg

Intervention Type: DRUG

Januvia Tab.100mg + Duvie Tab. 0.5mg\*1T/day for 5 dyas, QD, PO

Group 2(Treatment B/Treatment A)

Period 1: Treatment B(Januvia Tab. 100mg + Duvie Tab. 0.5mg)*1T/day for 5 dyas, QD, PO.

Period 2: Treatment A(Januvia Tab. 100mg)*1T/day for 5 dyas, QD, PO.

Each treatment period was separated by a washout period of at least 10 dyas.

Group Type: EXPERIMENTAL

Januvia Tab. 100mg

Intervention Type: DRUG

Januvia Tab. 100mg\*1T/day for 5days, QD, PO

Januvia Tab. 100mg + Duvie Tab. 0.5mg

Intervention Type: DRUG

Januvia Tab.100mg + Duvie Tab. 0.5mg\*1T/day for 5 dyas, QD, PO

Interventions

Januvia Tab. 100mg

Januvia Tab. 100mg\*1T/day for 5days, QD, PO

Intervention Type: DRUG

Januvia Tab. 100mg + Duvie Tab. 0.5mg

Januvia Tab.100mg + Duvie Tab. 0.5mg\*1T/day for 5 dyas, QD, PO

Intervention Type: DRUG

Other Intervention Names

Sitagliptin 100mg; Sitagliptin 100mg; Lobeglitazone 0.5mg

Eligibility Criteria

Inclusion Criteria

1. A healthy male whose age is over 19 years old when visiting for initial screening test.

2. Body mass index(BMI) between 17.5~30.5 kg/m^2 and the body weight must be over 55kg (Body mass index (BMI) = weight (kg) / height (m)^2) .

3. A male with no congenital or chronic disease in three years, no history of symptoms in internal treatment, or no knowledge in the area.

4. Due to the special characteristics of drugs, the participators must be qualified to do the clinical screening after examined through hematology test and blood chemistry analysis, urinary test, the electrocardiogram (ECG), and etc.

5. The participants must be volunteered and sign in an informed consent document proven by Chonbuk National University IRB before joining a study to show that he was given informed the purpose of tests and the special characteristics of drugs.

6. The participants must have an ability and willingness to participate throughout the entire trials.

Exclusion Criteria

1. A person who had a history or symptoms of clinically aware of blood, kidney, internal secretion, gastrointestinal, urinary system, cardiovascular, liver, mental, nercous, or allergic(except subclinical seasonal allergies that is not treated at injecion) desease.

2. Who had a gistory of gastrointestinal related disease which can be affected the drug absorption (esophageal achalasia, esophagostenosis, esophageal disease, or Crohn's disease) or surgeries (except a simple appendectomy or herniotomy).

3. Who had following results after examination(a. ALT or AST > twice higher than normal value).

4. Who constantly intake 210 g/week of alcohol within 6 months of the screening. (a cup of beer (5%) (250 mL) = 10 g, a shot of soju (20%) (50mL) = 8 g, a glass of wine (!2%) (125 mL) = 12g).

5. Who participated other clinical test or took testing bioequivalence drugs in 3 months before the first clinical drug trial.

6. Whose blood pressure ≤ 100 or ≥150(systolic blood pressure) or < 60 or ≥ 100(diastolic blood pressure).

7. Who had a medical history of alcohol and drug abuses.

8. Who had taken a drug that has a control of metabolic rate (activatioh or inhibithion) in 30 days before the first taking of clinical testing durg.

9. WHo smokes more than 20 eigarettes per day.

10. Who took prescribed drugs or over-the-conuter durgs in 10 days before taking of very first clinical testing drug.

11. Who participated in whole blood donation in 2 months before the first taking of clinical testing drugs or platelet donations in 1 month before the first taking to clinical testing drugs.

12. Who has a potent to increase a danger by participating in the clinical trials or sho can interrupt interpretin test results by having serious or chronic medical and mental status or having issues in results of the screening examination.

13. Who has a histroy of an extreme sensitivity of drugs that contain the ingredients of Sitagliptin or thiazolidinediones drugs or drugs that contain Rosiglitazone or dugs that have similar effect a Rosiglitazone(Pioglitazone).

14. Who has a serious heart failure or a congestive heart failure that must be drug-treated.

15. A patient with hepatopathy.

16. A patient with wevere nephropathy.

17. Who has diabetic ketoacidosis or a diaetic coma, or type 1 diabetes, or has history of acute metablic acidosis or ketoacidosis.

18. A patient with serious infectious disease or severe injuries before and after a surgery.

19. Who has Galactose intolerance, LAPP lactose intolerance, glucose-galactose malabsorption or genetic disorders.

20. Test subjects who is not willing or unable to comply with guidelines described in this protocol.

21. A person who is not determined unsuitable to participate in this test by the researchers.

• Minimum Eligible Age: 19 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

Chong Kun Dang Pharmaceutical

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Min-Gul Kim, MD,PhD

Role: STUDY_DIRECTOR

Chonbuk National University Hospital

Locations

Chonbuk National University Hospital

Jeonju, , South Korea

Countries

South Korea

References

Moon SJ, Yu KS, Kim MG. An Assessment of Pharmacokinetic Interaction Between Lobeglitazone and Sitagliptin After Multiple Oral Administrations in Healthy Men. Clin Ther. 2020 Jun;42(6):1047-1057. doi: 10.1016/j.clinthera.2020.04.005. Epub 2020 Apr 30.

Reference Type: DERIVED

PMID: 32362346 (View on PubMed)

Other Identifiers

165DDI16003

Identifier Type: -

Identifier Source: org_study_id