Centella Asiatica (Gotukola) Mouthwash as an Adjunct to Mechanical Plaque Control

NCT ID: NCT02827305

Last Updated: 2016-07-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

36 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-08-31

Study Completion Date

2015-08-31

Brief Summary

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This study evaluates the adjunctive use of Centella Asiatica (gotukola) to scaling in the reduction of plaque and gingival inflammation. Patients were divided into three groups of which group 1 received scaling and gotukola mouthwash, group 2 received scaling only and group 3 received gotukola mouthwash only.

Detailed Description

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Mechanical plaque control by tooth brushing is considered to be the ideal way of preventing plaque associated gingivitis. However due to various factors individuals fail to perform an adequate quality of self performed plaque control. Centella Asiatica (gotukola) possess wide range of biological activities like anti-inflammatory, anti-psoriatic, anti-ulcer, hepato-protective, anticonvulsant, immunostimulant, cardioprotective, antidiabetic, antiviral, antibacterial, antifungal, etc. So, it could be used as adjunctive to mechanical periodontal therapy.

Conditions

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Gingival Diseases

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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group 1

scaling and Gotukola mouthwash intervention- 1.Scaling 2.Gotukola mouthwash , 10ml twice daily to be rinsed for 60 seconds

Group Type EXPERIMENTAL

Gotukola

Intervention Type DRUG

10 ml of mouthwash to be rinsed for duration of 60 seconds

Scaling

Intervention Type PROCEDURE

Ultrasonic scaling was performed in one visit on both upper and lower arches.

group 2

Scaling

Group Type ACTIVE_COMPARATOR

Scaling

Intervention Type PROCEDURE

Ultrasonic scaling was performed in one visit on both upper and lower arches.

group 3

Intervention- Gotukola mouthwash only is advised to be used two times a day, each time 10ml rinsed for 60 seconds (morning and evening ) after the food.

Group Type ACTIVE_COMPARATOR

Gotukola

Intervention Type DRUG

10 ml of mouthwash to be rinsed for duration of 60 seconds

Interventions

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Gotukola

10 ml of mouthwash to be rinsed for duration of 60 seconds

Intervention Type DRUG

Scaling

Ultrasonic scaling was performed in one visit on both upper and lower arches.

Intervention Type PROCEDURE

Other Intervention Names

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Centella Asiatica

Eligibility Criteria

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Inclusion Criteria

* Minimum of 22 natural teeth
* Participants with Chronic generalized gingivitis
* Participants with plaque index score ≥1

Exclusion Criteria

* Participants with fixed or removable appliances
* Participants with more than full coverage restorations
* Medically compromised participants
* Participants on long term medications
* Smokers
* Participants who had used any type of antibacterial mouthwash in 4weeks of commencement.
* Patients with history of recent periodontal therapy
Minimum Eligible Age

14 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Sri Hasanamba Dental College and Hospital

OTHER

Sponsor Role lead

Responsible Party

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Talat Mohammadi

Post graduate student

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Talat Mohammadi, PG student

Role: PRINCIPAL_INVESTIGATOR

Sri Hasanamba Dental College and Hospital

Locations

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Talat Mohammadi

Hassan, Karnataka, India

Site Status

Countries

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India

References

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Sastravaha G, Yotnuengnit P, Booncong P, Sangtherapitikul P. Adjunctive periodontal treatment with Centella asiatica and Punica granatum extracts. A preliminary study. J Int Acad Periodontol. 2003 Oct;5(4):106-15.

Reference Type BACKGROUND
PMID: 14604059 (View on PubMed)

Sastravaha G, Gassmann G, Sangtherapitikul P, Grimm WD. Adjunctive periodontal treatment with Centella asiatica and Punica granatum extracts in supportive periodontal therapy. J Int Acad Periodontol. 2005 Jul;7(3):70-9.

Reference Type BACKGROUND
PMID: 16022023 (View on PubMed)

Other Identifiers

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SHDCH/2015-16/1409

Identifier Type: -

Identifier Source: org_study_id

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