Study Results
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Basic Information
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UNKNOWN
104 participants
OBSERVATIONAL
2013-11-30
2016-09-30
Brief Summary
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Thus the investigators wanted to test the hypothesis that onycholysis, in patients without PsA, is a potential clinical marker of subclinical distal enthesopathy and, by extension, of bone micro-structural alterations.
Patients and Methods
The investigators will recruit 4 groups of subjects:
1. Patients with peripheral PsA,
2. Patients with psoriatic nail onycholysis,
3. Patients with PsO only
4. Healthy match control subjects. The investigators will assess the presence of enthesopathy by ultrasonography and bone structural damages (by HR-pQCT) in all subjects at baseline and 4 years.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Patients with peripheral PsA
HR-pQCT High resolution peripheral quantitative CT-scan
HR-pQCT is a powerful device providing low dose irradiation already used in bone field.
It is a high resolution tool (voxel size=82µm) that the investigators adapted to look after the distal joint involved by onycholysis. An anteroposterior scout view is used to define the region of interest (ROI), which spanned from the top of the distal phalange to the distal part of the intermediate phalange in order to contain the distal joint of the target finger. Images are then analysed for erosions, osteophytes and volumetric bone mineral density.
Patients with psoriatic nail onycholysis
HR-pQCT High resolution peripheral quantitative CT-scan
HR-pQCT is a powerful device providing low dose irradiation already used in bone field.
It is a high resolution tool (voxel size=82µm) that the investigators adapted to look after the distal joint involved by onycholysis. An anteroposterior scout view is used to define the region of interest (ROI), which spanned from the top of the distal phalange to the distal part of the intermediate phalange in order to contain the distal joint of the target finger. Images are then analysed for erosions, osteophytes and volumetric bone mineral density.
Patients with PsO only
HR-pQCT High resolution peripheral quantitative CT-scan
HR-pQCT is a powerful device providing low dose irradiation already used in bone field.
It is a high resolution tool (voxel size=82µm) that the investigators adapted to look after the distal joint involved by onycholysis. An anteroposterior scout view is used to define the region of interest (ROI), which spanned from the top of the distal phalange to the distal part of the intermediate phalange in order to contain the distal joint of the target finger. Images are then analysed for erosions, osteophytes and volumetric bone mineral density.
Healthy match control subjects
HR-pQCT High resolution peripheral quantitative CT-scan
HR-pQCT is a powerful device providing low dose irradiation already used in bone field.
It is a high resolution tool (voxel size=82µm) that the investigators adapted to look after the distal joint involved by onycholysis. An anteroposterior scout view is used to define the region of interest (ROI), which spanned from the top of the distal phalange to the distal part of the intermediate phalange in order to contain the distal joint of the target finger. Images are then analysed for erosions, osteophytes and volumetric bone mineral density.
Interventions
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HR-pQCT High resolution peripheral quantitative CT-scan
HR-pQCT is a powerful device providing low dose irradiation already used in bone field.
It is a high resolution tool (voxel size=82µm) that the investigators adapted to look after the distal joint involved by onycholysis. An anteroposterior scout view is used to define the region of interest (ROI), which spanned from the top of the distal phalange to the distal part of the intermediate phalange in order to contain the distal joint of the target finger. Images are then analysed for erosions, osteophytes and volumetric bone mineral density.
Eligibility Criteria
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Inclusion Criteria
* both gender
* covered by the French National Insurance
* subjects entering one of the 4 groups.
Exclusion Criteria
18 Years
65 Years
ALL
Yes
Sponsors
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Hospices Civils de Lyon
OTHER
Responsible Party
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Principal Investigators
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Cyrille Confavreux, MD PHD
Role: PRINCIPAL_INVESTIGATOR
Hospices Civils de Lyon, France
Locations
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Centre des Métastases Osseuses (CEMOS) Pavillon F - Rhumatology Hôpital Edouard Herriot, 5 place d'Arsonval
Lyon, , France
Countries
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Central Contacts
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Céline Coutisson, clinical research assistant
Role: CONTACT
Facility Contacts
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Céline Coutisson, clinical research assistant
Role: backup
References
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Villani AP, Boutroy S, Coutisson C, Carlier MC, Barets L, Marotte H, Richert B, Chapurlat RD, Jullien D, Confavreux CB. Distal phalangeal bone erosions observed by HR-pQCT in patients with psoriatic onycholysis. Rheumatology (Oxford). 2021 Mar 2;60(3):1176-1184. doi: 10.1093/rheumatology/keaa415.
Other Identifiers
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69HCL16_0202
Identifier Type: -
Identifier Source: org_study_id
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