Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
95 participants
OBSERVATIONAL
2014-11-25
2017-09-19
Brief Summary
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It's a familial, epidemiological, prospective, single-center study.
Detailed Description
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Currently, keratoconus has not known etiopathogenesis, and it is difficult to detect subclinical forms.
Several risk factors seem to be implied, environmental and genetic : the risk of keratoconus in case of familial history of keratoconus isn't well known at that time, but seems to be important to consider to promote screening and follow up of patient with a familial history of keratoconus (KC).
Conditions
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Study Design
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FAMILY_BASED
PROSPECTIVE
Interventions
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genetic
Galilee exam - Corn analysis with Optiwave Refractive Analysis
Eligibility Criteria
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Inclusion Criteria
* patient carrier of keratoconus
* more than 7 years
* patient who didn't expressed opposition as for computerization and use of data concerning him
Family of case
* to have a first degree family member (father, mother, brother, sister, child) carrier of keratoconus
* more than 7 years
* patient who didn't expressed opposition as for computerization and use of data concerning him
Exclusion Criteria
* wearing of rigid contact lens for 15 days before exams, or flexible lens for 5 days before exams
7 Years
ALL
Yes
Sponsors
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University Hospital, Bordeaux
OTHER
Responsible Party
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Principal Investigators
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David Touboul, MD
Role: PRINCIPAL_INVESTIGATOR
University Hospital Bordeaux, France
Locations
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Centre de Référence National du Kératocône Service d'ophtalmologie - Hôpital Pellegrin
Bordeaux, , France
Countries
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References
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Millodot M, Shneor E, Albou S, Atlani E, Gordon-Shaag A. Prevalence and associated factors of keratoconus in Jerusalem: a cross-sectional study. Ophthalmic Epidemiol. 2011 Apr;18(2):91-7. doi: 10.3109/09286586.2011.560747.
Weed KH, MacEwen CJ, Giles T, Low J, McGhee CN. The Dundee University Scottish Keratoconus study: demographics, corneal signs, associated diseases, and eye rubbing. Eye (Lond). 2008 Apr;22(4):534-41. doi: 10.1038/sj.eye.6702692. Epub 2007 Jan 19.
Assiri AA, Yousuf BI, Quantock AJ, Murphy PJ. Incidence and severity of keratoconus in Asir province, Saudi Arabia. Br J Ophthalmol. 2005 Nov;89(11):1403-6. doi: 10.1136/bjo.2005.074955.
Owens H, Gamble G. A profile of keratoconus in New Zealand. Cornea. 2003 Mar;22(2):122-5. doi: 10.1097/00003226-200303000-00008.
McMonnies CW, Boneham GC. Keratoconus, allergy, itch, eye-rubbing and hand-dominance. Clin Exp Optom. 2003 Nov;86(6):376-84. doi: 10.1111/j.1444-0938.2003.tb03082.x.
Falls HF, Allen AW. Dominantly inherited keratoconus. J Genet Hum. 1969 Oct;17(3):317-24. No abstract available.
Kemp EG, Lewis CJ. Measurement of total and specific IgE levels in the management of a family exhibiting a high incidence of keratoconus. Acta Ophthalmol (Copenh). 1984 Aug;62(4):524-9. doi: 10.1111/j.1755-3768.1984.tb03963.x.
Ihalainen A. Clinical and epidemiological features of keratoconus genetic and external factors in the pathogenesis of the disease. Acta Ophthalmol Suppl (1985). 1986;178:1-64.
Rabinowitz YS, Garbus J, McDonnell PJ. Computer-assisted corneal topography in family members of patients with keratoconus. Arch Ophthalmol. 1990 Mar;108(3):365-71. doi: 10.1001/archopht.1990.01070050063032.
Other Identifiers
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CHUBX2013/03
Identifier Type: -
Identifier Source: org_study_id