Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
EARLY_PHASE1
16 participants
INTERVENTIONAL
2015-06-30
2021-08-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
QUADRUPLE
Study Groups
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Active
Sildenafil 100 mg single dose
Sildenafil
Single oral administration of active or placebo one week apart
Placebo
Placebo capsule
Placebo
Interventions
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Sildenafil
Single oral administration of active or placebo one week apart
Placebo
Eligibility Criteria
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Inclusion Criteria
* Minimum of 2 attacks/year
Exclusion Criteria
* History of cardio- or cerebrovascular diseases
* Hypertension or hypotension
* Any daily intake of medication, including prophylactic migraine treatment, except oral contraceptives
* Pregnancy and lactation
18 Years
50 Years
ALL
No
Sponsors
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Herlev Hospital
OTHER
Responsible Party
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Christina Kruuse
Consultant neurologist, associate professor
Principal Investigators
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Christina Kruuse, MD, DMSc
Role: PRINCIPAL_INVESTIGATOR
Department of Neurology, Herlev-Gentofte Hospital
Locations
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Department of Neurology, Herlev-Gentofte Hospital
Herlev, , Denmark
Countries
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References
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Butt JH, S Eddelien H, Kruuse C. The headache and aura-inducing effects of sildenafil in patients with migraine with aura. Cephalalgia. 2022 Sep;42(10):984-992. doi: 10.1177/03331024221088998. Epub 2022 Mar 25.
Other Identifiers
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H-15008491
Identifier Type: -
Identifier Source: org_study_id