Trial Outcomes & Findings for Variations in Anesthesia Care for Hip Fracture Surgery (NCT NCT02787031)

Results Overview

Recruitment status

COMPLETED

Target enrollment

107317 participants

Primary outcome timeframe

Day of surgery to day of death, or up to 30 days, whichever comes first

Results posted on

2025-03-17

Participant Flow

Participant milestones

Participant milestones
Measure	Neuraxial Anesthesia Participants in this group will be those who had a spinal or epidural anesthetic without concurrent general anesthesia Neuraxial anesthesia	General Anesthesia Participants in this group will be those who had general anesthesia, including those who had a general plus a concurrent spinal or epidural anesthetic. General anesthesia
Overall Study STARTED	57080	50237
Overall Study COMPLETED	57080	50237
Overall Study NOT COMPLETED	0	0

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Variations in Anesthesia Care for Hip Fracture Surgery

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	Neuraxial Anesthesia n=57080 Participants Participants in this group will be those who had a spinal or epidural anesthetic without concurrent general anesthesia Neuraxial anesthesia	General Anesthesia n=50237 Participants Participants in this group will be those who had general anesthesia, including those who had a general plus a concurrent spinal or epidural anesthetic. General anesthesia	Total n=107317 Participants Total of all reporting groups
Age, Continuous	83 years STANDARD_DEVIATION 7 • n=5 Participants	82 years STANDARD_DEVIATION 8 • n=7 Participants	83 years STANDARD_DEVIATION 8 • n=5 Participants
Sex: Female, Male Female	41954 Participants n=5 Participants	36874 Participants n=7 Participants	78828 Participants n=5 Participants
Sex: Female, Male Male	15126 Participants n=5 Participants	13363 Participants n=7 Participants	28489 Participants n=5 Participants
Neighbourhood income quintile	3 Neighbourhood income quintile n=5 Participants	3 Neighbourhood income quintile n=7 Participants	3 Neighbourhood income quintile n=5 Participants

PRIMARY outcome

Timeframe: Day of surgery to day of death, or up to 30 days, whichever comes first

Population: Data were not collected from the participants in the "General Anesthesia" Arm/Group. Only neuraxial group data available for all cause 30-day mortality. The aim was to measure the association of hospital-level utilization of neuraxial anesthesia, independent of patient-level use, with 30-day survival and length of stay and costs.

Outcome measures

Outcome measures
Measure	Neuraxial Anesthesia n=57080 Participants Participants in this group will be those who had a spinal or epidural anesthetic without concurrent general anesthesia Neuraxial anesthesia	General Anesthesia Participants in this group will be those who had general anesthesia, including those who had a general plus a concurrent spinal or epidural anesthetic. General anesthesia
Number of Participants With All-Cause Mortality at 30-days	9122 Participants	—

SECONDARY outcome

Timeframe: Day of surgery to day of death, or 30 days after surgery, whichever comes first

Population: Data were not collected from the participants in the "General Anesthesia" Arm/Group. Only neuraxial group data available for healthcare costs. The aim was to measure the association of hospital-level utilization of neuraxial anesthesia, independent of patient-level use, with 30-day survival and length of stay and costs.

Outcome measures

Outcome measures
Measure	Neuraxial Anesthesia n=57080 Participants Participants in this group will be those who had a spinal or epidural anesthetic without concurrent general anesthesia Neuraxial anesthesia	General Anesthesia Participants in this group will be those who had general anesthesia, including those who had a general plus a concurrent spinal or epidural anesthetic. General anesthesia
Healthcare Costs From the Perspective of the Universal Healthcare System, Using Standardized Methods (Health System Performance Research Network 2013)	22138 Canadian Dollars Interval 16430.0 to 28354.0	—

OTHER_PRE_SPECIFIED outcome

Timeframe: Day of surgery to day of discharge, or up to 365 days, whichever comes first

Population: Data were not collected from the participants in the "General Anesthesia" Arm/Group. Only neuraxial group data available for hospital length of stay The aim was to measure the association of hospital-level utilization of neuraxial anesthesia, independent of patient-level use, with 30-day survival and length of stay and costs.

Outcome measures

Outcome measures
Measure	Neuraxial Anesthesia n=57080 Participants Participants in this group will be those who had a spinal or epidural anesthetic without concurrent general anesthesia Neuraxial anesthesia	General Anesthesia Participants in this group will be those who had general anesthesia, including those who had a general plus a concurrent spinal or epidural anesthetic. General anesthesia
Hospital Length of Stay	9 Days Interval 6.0 to 18.0	—

Adverse Events

Neuraxial Anesthesia

Serious events: 0 serious events

Other events: 0 other events

Deaths: 9122 deaths

General Anesthesia

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Dr. Daniel McIsaac

The Ottawa Hospital

Phone: 613-761-4940

Email: [email protected]

Results disclosure agreements

Principal investigator is a sponsor employee
Publication restrictions are in place