Histological Differentiation Grade Predicted by Ultrasound Backscatterer Imaging
NCT ID: NCT02786199
Last Updated: 2016-05-30
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
100 participants
OBSERVATIONAL
2015-06-30
2018-06-30
Brief Summary
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Ultrasound is an imaging modality frequently used to evaluate liver tumors because of its convenience, real-time, less expensive and no radiation exposure. However, ultrasonographic evaluation by conventional B-mode image is semi quantitative and subjective. It still cannot replace liver biopsy for the evaluation of HCC.
This study is aimed to quantify the image characters of B-mode image and the scatterer properties using Nakagami distribution. Nakagami parameter is a general model to describe the distribution of scatterers. Therefore, the investigators hypothesized that Nakagami parameter may also reflect the histological changes in different grades of HCC.
In this study, the resected HCC tumor samples will be collected from the participants who are going to receive surgical resection, and the tumor US images and Nakagami values will be obtained via the single-element ultrasound system. The correlation between the ultrasound backscatter parameter and the differentiation grade will be analyzed.
Detailed Description
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Conditions
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Keywords
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Study Design
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CASE_ONLY
PROSPECTIVE
Study Groups
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Hepatocellular carcinoma
patients HCC who are going to receive surgical resection
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Patients with HCC who underwent surgery
* The resected tumor was measured larger than 3 cm
Exclusion Criteria
* Patients who couldn't regular follow-up
20 Years
75 Years
ALL
No
Sponsors
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National Taiwan University Hospital
OTHER
Responsible Party
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Principal Investigators
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Ming-Chih Ho, MD
Role: PRINCIPAL_INVESTIGATOR
Department of Surgery, National Taiwan University Hospital
Locations
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National Taiwan University Hospital
Taipei, , Taiwan
Countries
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Central Contacts
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Facility Contacts
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Ming-Chih Ho, MD/PhD
Role: primary
Other Identifiers
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201505107RINA
Identifier Type: -
Identifier Source: org_study_id