Clinical Trial on Ganoderma Spore Lipids Combined With Chemo in Patients With G.I. Cancers

NCT ID: NCT02785523

Last Updated: 2016-05-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE3

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-05-31

Brief Summary

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A phase III double-blind randomized clinical trial on the effects of ganoderma spore lipids to the immunological response in patients with G.I. Cancers. The trial is randomized, double-blind. Cancer patients are diagnosed based on pathology or cell biology. Patients are randomized into 2 groups: both groups receive chemotherapy. Either group receives ganoderma spore lipids or placebo capsules 600mg three times a day (TID) in addition to the chemotherapy. Clinical evaluation includes chemotherapy drug toxicities, life quality improvement. Blood biochemistry tests mainly include malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), adrenaline, nor-adrenaline, tumor necrosis factor (TNF)-α, interleukin (IL)-1b, interleukin (IL)-6, cell flow cytometry on Th1, Th2, Th17, Treg cytokines, as well as serum cortisol, estradiol (female), progesterone (female), testosterone (male), etc.

Detailed Description

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Conditions

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Gastrointestinal Neoplasms

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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G. SPORE LIPIDS

Form: Capsule Dosage and frequency: This group receives ganoderma spore lipids capsules 600mg TID in addition to the chemotherapy.

Duration: 6 chemotherapy cycles.

Group Type EXPERIMENTAL

Ganoderma Spore Lipids

Intervention Type DRUG

Chemotherapy

Intervention Type DRUG

Placebo

Form: Capsule Dosage and frequency: This group receives placebo capsules 600mg TID in addition to the chemotherapy.

Duration: 6 chemotherapy cycles.

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Chemotherapy

Intervention Type DRUG

Interventions

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Ganoderma Spore Lipids

Intervention Type DRUG

Placebo

Intervention Type DRUG

Chemotherapy

Intervention Type DRUG

Other Intervention Names

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G. SPORE LIPIDS

Eligibility Criteria

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Inclusion Criteria

* Age: 18-80, male and female.
* Diagnosis: imaging, cell and pathology report.
* Eastern Cooperative Oncology Group (ECOG) O-2, life expectancy more than 3 months.
* Chemotherapy is not contraindicated.
* No apparent surgical trauma during the previous 2 weeks.
* Past treatment:

* Biological treatment: at least 4 weeks after previous treatment with immunotherapy or other biological; chemotherapy, at least 6 months after last treatment with chemotherapy and or target therapy.
* Surgery: had not received transplantation surgery, at least 2 weeks after last major surgery.

Exclusion Criteria

* A purulent and chronic infection of wound healing delayed.
* Diseases of the blood system.
* Abnormal blood coagulation function.
* Severe brain disease or primary brain tumors without control, and mentally ill person.
* Patients with brain metastases.
* Pregnant or lactating women.
* Patients (male/female) with fertility, But the patients themselves or their spouses do not take effective contraception.
* Allergic constitution.
* In addition, patients taking part in other clinical trials, being treated with other biotherapy or immunotherapy and researchers consider not suitable for clinical subjects for other reasons will be excluded.
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Xiaonan Cui

OTHER

Sponsor Role lead

Responsible Party

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Xiaonan Cui

Professor, Chief Physician

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Xiaonan Cui, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

The First Affiliated Hospital of Dalian Medical University

Locations

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The First Affiliated Hospital of Dalian Medical University

Dalian, Liaoning, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Xiaonan Cui, MD, PhD

Role: CONTACT

Phone: +8618098876725

Email: [email protected]

Facility Contacts

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Xiaonan Cui, MD,PhD

Role: primary

Other Identifiers

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G20090400

Identifier Type: -

Identifier Source: org_study_id