A Study of Lanabecestat (LY3314814) in Participants With Mild Alzheimer's Disease Dementia

NCT ID: NCT02783573

Last Updated: 2019-12-03

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE3

Total Enrollment

1722 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-07-01

Study Completion Date

2018-09-28

Brief Summary

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The main purpose of this study is to evaluate the efficacy of the study drug known as lanabecestat in participants with mild Alzheimer's disease (AD) dementia.

Detailed Description

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Conditions

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Alzheimer's Disease

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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Lanabecestat 20 milligrams (mg)

Participants received Lanabecestat 20 mg film-coated tablets orally once daily until week 156.

Group Type EXPERIMENTAL

Lanabecestat

Intervention Type DRUG

Administered orally

Lanabecestat 50 mg

Participants received Lanabecestat 50 mg film-coated tablets orally once daily until week 156.

Group Type EXPERIMENTAL

Lanabecestat

Intervention Type DRUG

Administered orally

Placebo/ Lanabecestat 20 mg

Placebo given orally once daily for 78 weeks and then 20 mg of lanabecestat given orally once daily until week 156.

Group Type EXPERIMENTAL

Lanabecestat

Intervention Type DRUG

Administered orally

Placebo

Intervention Type DRUG

Administered orally

Placebo/ Lanabecestat 50 mg

Placebo given orally once daily for 78 weeks and then 50 mg of lanabecestat given orally once daily until week 156.

Group Type EXPERIMENTAL

Lanabecestat

Intervention Type DRUG

Administered orally

Placebo

Intervention Type DRUG

Administered orally

Interventions

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Lanabecestat

Administered orally

Intervention Type DRUG

Placebo

Administered orally

Intervention Type DRUG

Other Intervention Names

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LY3314814 AZD3293

Eligibility Criteria

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Inclusion Criteria

* Participant must meet the National Institute on Aging (NIA) and the Alzheimer's Association (AA) (NIA-AA) criteria for probable AD dementia.
* MMSE score of 20 to 26 inclusive at screening visit.
* For a diagnosis of mild AD dementia, participant must have a CDR global score of 0.5 or 1, with the memory box score ≥0.5 at screening.
* Evidence of amyloid pathology.
* The participant must have a reliable study partner with whom he/she cohabits or has regular contact.

Exclusion Criteria

* Significant and/or current neurological disease affecting the central nervous system, other than AD, that may affect cognition or ability to complete the study, including but not limited to, other dementias, repetitive head trauma, serious infection of the brain, Parkinson's disease, epilepsy, or cervicocranial vascular disease.
* Participants with any current primary psychiatric diagnosis other than AD if, in the judgment of the investigator, the psychiatric disorder or symptom is likely to confound interpretation of drug effect, affect cognitive assessment, or affect the participant's ability to complete the study. Participants with history of schizophrenia or other chronic psychosis are excluded.
* Within 1 year before the screening visit or between screening and randomization, any of the following: myocardial infarction; moderate or severe congestive heart failure, New York Heart Association class III or IV; hospitalization for, or symptoms of, unstable angina; syncope due to orthostatic hypotension or unexplained syncope; known significant structural heart disease (such as, significant valvular disease, hypertrophic cardiomyopathy); or hospitalization for arrhythmia.
* Congenital QT prolongation.
* Intermittent second- or third-degree atrioventricular (AV) heart block or AV dissociation or history of ventricular tachycardia.
* A corrected QT (QTcF) interval measurement \>470 milliseconds (men and women) at screening (as determined at the investigational site).
* History of malignant cancer within the last 5 years.
* History of vitiligo and/or current evidence of post-inflammatory hypopigmentation.
* Calculated creatinine clearance \<30 milliliters per minute (Cockcroft-Gault formula; Cockcroft and Gault 1976) at screening.
* Currently enrolled in any other clinical trial involving an investigational product or any other type of medical research judged not to be scientifically or medically compatible with this study.
Minimum Eligible Age

55 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Eli Lilly and Company

INDUSTRY

Sponsor Role collaborator

AstraZeneca

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST)

Role: STUDY_DIRECTOR

Eli Lilly and Company

Locations

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Xenoscience

Phoenix, Arizona, United States

Site Status

St Josephs Hospital and Medical Center

Phoenix, Arizona, United States

Site Status

Four Peaks Neurology

Scottsdale, Arizona, United States

Site Status

Arizona Neurology

Scottsdale, Arizona, United States

Site Status

Center for Neurosciences

Tucson, Arizona, United States

Site Status

NEA Baptist Clinical

Jonesboro, Arkansas, United States

Site Status

The Research Center of Southern California

Carlsbad, California, United States

Site Status

WCCT Global

Costa Mesa, California, United States

Site Status

Neuro-Pain Medical Center

Fresno, California, United States

Site Status

Neurology Center of North Orange County

Fullerton, California, United States

Site Status

Pacific Neuroscience Medical Group

Oxnard, California, United States

Site Status

California Research Foundation

San Diego, California, United States

Site Status

Pacific Research Network Inc

San Diego, California, United States

Site Status

Sharp Mesa Vista Hospital

San Diego, California, United States

Site Status

Syrentis Clinical Research

Santa Ana, California, United States

Site Status

Care Access Research

Santa Clarita, California, United States

Site Status

California Neuroscience Research

Sherman Oaks, California, United States

Site Status

Care Access Research

Valencia, California, United States

Site Status

Associated Neurologists, PC - Danbury

Danbury, Connecticut, United States

Site Status

Institute for Neurodegenerative Disorders

New Haven, Connecticut, United States

Site Status

Yale University School of Medicine

New Haven, Connecticut, United States

Site Status

Research Center for Clinical Studies, Inc

Norwalk, Connecticut, United States

Site Status

JEM Research Institute

Atlantis, Florida, United States

Site Status

Morton Plant Hospital

Clearwater, Florida, United States

Site Status

Brain Matters Research

Delray Beach, Florida, United States

Site Status

Cohen Medical Associates P.A.

Delray Beach, Florida, United States

Site Status

Neuropsychiatric Research Center of Southwest Florida

Fort Myers, Florida, United States

Site Status

Indago Research & Health Center, Inc.

Hialeah, Florida, United States

Site Status

Infinity Clinical Research, LLC

Hollywood, Florida, United States

Site Status

Jacksonville Center for Clinical Research

Jacksonville, Florida, United States

Site Status

Mayo Clinic-Jacksonville

Jacksonville, Florida, United States

Site Status

Gregory A. Kirk MD LLC

Merritt Island, Florida, United States

Site Status

University of Miami

Miami, Florida, United States

Site Status

Allied Biomedical Research Institute, Inc.

Miami, Florida, United States

Site Status

Compass Research

Orlando, Florida, United States

Site Status

Quantum Laboratories

Pompano Beach, Florida, United States

Site Status

Charlotte Neurological Services

Port Charlotte, Florida, United States

Site Status

Intercoastal Medical Group

Sarasota, Florida, United States

Site Status

Axiom Research

Tampa, Florida, United States

Site Status

University of South Florida

Tampa, Florida, United States

Site Status

Emory University

Atlanta, Georgia, United States

Site Status

Atlanta Center of Medical Research

Atlanta, Georgia, United States

Site Status

Georgia Regents University

Augusta, Georgia, United States

Site Status

Medical Research Health and Education Foundation, Inc

Columbus, Georgia, United States

Site Status

Hawaii Medical Center

Honolulu, Hawaii, United States

Site Status

Advanced Clinical Research LLC

Meridian, Idaho, United States

Site Status

American Health Network

Avon, Indiana, United States

Site Status

Josephson Wallack Munshower Neurology

Indianapolis, Indiana, United States

Site Status

American Health Network

Muncie, Indiana, United States

Site Status

University of Kansas Hospital

Fairway, Kansas, United States

Site Status

Cotton O'Neil Clinic

Topeka, Kansas, United States

Site Status

Via Christi Research, Inc.

Wichita, Kansas, United States

Site Status

Baptist Health Medical Group

Lexington, Kentucky, United States

Site Status

Associates in Neurology, PSC

Lexington, Kentucky, United States

Site Status

Eastern Maine Medical Center

Bangor, Maine, United States

Site Status

Maine Neurology

Scarborough, Maine, United States

Site Status

Boston University Medical Center

Boston, Massachusetts, United States

Site Status

Donald S Marks

Plymouth, Massachusetts, United States

Site Status

Alzheimers Disease Center

Winchester, Massachusetts, United States

Site Status

Michigan State University

East Lansing, Michigan, United States

Site Status

Hattiesburg Clinic

Hattiesburg, Mississippi, United States

Site Status

Clinical Research Professionals

St Louis, Missouri, United States

Site Status

Las Vegas Medical Research

Las Vegas, Nevada, United States

Site Status

Advanced Memory Research Institute of New Jersey

Toms River, New Jersey, United States

Site Status

Neurology Specialists of Monmouth County

West Long Branch, New Jersey, United States

Site Status

New York University Medical Center

New York, New York, United States

Site Status

Behavioral Health Center Research

Charlotte, North Carolina, United States

Site Status

Raleigh Neurology Associates

Raleigh, North Carolina, United States

Site Status

PMG Research of Winston-Salem, LLC

Winston-Salem, North Carolina, United States

Site Status

Wake Forest Baptist Univ CAR

Winston-Salem, North Carolina, United States

Site Status

Rapid Medical Research Inc

Cleveland, Ohio, United States

Site Status

Ohio State University Medical Center

Columbus, Ohio, United States

Site Status

Insight Clinical Trials

Shaker Heights, Ohio, United States

Site Status

Lynn Health Science Institute

Oklahoma City, Oklahoma, United States

Site Status

Cutting Edge Research Group

Oklahoma City, Oklahoma, United States

Site Status

The Corvallis Clinic P.C.

Corvallis, Oregon, United States

Site Status

Summit Research Network Inc

Portland, Oregon, United States

Site Status

Clinical Trial Center, LLC, Psychiatry

Jenkintown, Pennsylvania, United States

Site Status

Pearl Clinical Research Inc.

Norristown, Pennsylvania, United States

Site Status

Rhode Island Mood & Memory Research Institute

East Providence, Rhode Island, United States

Site Status

Rhode Island Hospital

Providence, Rhode Island, United States

Site Status

Butler Hospital

Providence, Rhode Island, United States

Site Status

Medical University of South Carolina

Charleston, South Carolina, United States

Site Status

Radiant Research

Greer, South Carolina, United States

Site Status

Coastal Neurology PA

Port Royal, South Carolina, United States

Site Status

Holston Medical Group Clinical Research

Kingsport, Tennessee, United States

Site Status

Univ of North Texas Health Science Center

Fort Worth, Texas, United States

Site Status

Texas Medical Research Associates, L.L.C.

San Antonio, Texas, United States

Site Status

Ericksen Research and Development

Clinton, Utah, United States

Site Status

SSM Health Dean Medical Group

Madison, Wisconsin, United States

Site Status

University of Calgary

Calgary, Alberta, Canada

Site Status

The Medical Arts Health Research Group

West Vancouver, British Columbia, Canada

Site Status

True North Clinical Research Halifax, LLC

Halifax, Nova Scotia, Canada

Site Status

Bruyere Continuing Care

Ottawa, Ontario, Canada

Site Status

Kawartha Regional Memory Clinic

Peterborough, Ontario, Canada

Site Status

Toronto Memory Program

Toronto, Ontario, Canada

Site Status

Toronto Sunnybrook Regional Cancer Center

Toronto, Ontario, Canada

Site Status

CSSS-Institut Universitaire Gériatric de Sherbrooke

Sherbrooke, Qubec, Canada

Site Status

Recherches Neuro-Hippocampe Inc

Gatineau, Quebec, Canada

Site Status

Q&T Research Sherbrooke Inc

Sherbrooke, Quebec, Canada

Site Status

Douglas Hospital and Research Centre

Verdun, Quebec, Canada

Site Status

Xuanwu Hospital-Capital Medical University

Beijing, Beijing Municipality, China

Site Status

Beijing 301 Hospital

Beijing, Beijing Municipality, China

Site Status

Guangzhou First People's Hospital

Guangzhou, Guangdong, China

Site Status

Tangshan Worker Hospital

Tangshan, Hebei, China

Site Status

Nanjing Drum Tower Hosp Affiliated Hosp of Nanjing Univ Med

Nanjing, Jiangsu, China

Site Status

Zhongda Hospital-Southeast University

Nanjing, Jiangsu, China

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Northern Jiangsu People's Hospital

Yangzhou, Jiangsu, China

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Qingdao Municipal Hospital

Qingdao, Shandong, China

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Shanghai Tongji Hospital(CCBR site)

Shanghai, Shanghai Municipality, China

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West China Hospital of Sichuan University

Chengdu, Sichuan, China

Site Status

The First Affiliated Hospital, Zhejiang University

Hangzhou, Zhejiang, China

Site Status

The First Affiliated Hospital of Wenzhou Medical College

Wenzhou, Zhejiang, China

Site Status

Shanghai Huashan Hospital Affil to Fu Dan University

Shanghai, , China

Site Status

Fakultni nemocnice u sv. Anny v Brne

Brno, , Czechia

Site Status

Neurohk s.r.o.

Choceň, , Czechia

Site Status

Neuropsychiatrie s.r.o

Hradec Králové, , Czechia

Site Status

Brain-Soultherapy s.r.o

Kladno, , Czechia

Site Status

A-Shine s.r.o.

Pilsen, , Czechia

Site Status

Clintrial, s.r.o.

Prague, , Czechia

Site Status

Neuropsychiatrie s.r.o

Prague, , Czechia

Site Status

Medical Services Prague s.r.o.

Prague, , Czechia

Site Status

Axon Clinical, s.r.o.

Prague, , Czechia

Site Status

CCBR-Alborg-DK

Aalborg, , Denmark

Site Status

Center For Clinical and Basic Research

Ballerup Municipality, , Denmark

Site Status

Rigshospitalet

Copenhagen, , Denmark

Site Status

Center for Clinical and Basic Research -CCBR

Vejle, , Denmark

Site Status

Institut Claude Pompidou - CMRR

Nice, Alpes Maritimes, France

Site Status

CHU Rennes/Hopital Sud

Rennes, Ille Et Vilaine, France

Site Status

Chu De Nancy Hop D'Adultes De Brabois

Vandœuvre-lès-Nancy, Meurthe-et-Moselle, France

Site Status

CHU Saint Etienne - Hopital Nord

Saint Priest En Jarez, Pays de la Loire Region, France

Site Status

CHU d'Amiens-Picardie Hopital Sud

Amiens, , France

Site Status

CHU de Caen Hopital Cote de Nacre

Caen, , France

Site Status

APHM Hôpital de la Timone

Marseille, , France

Site Status

Hôpital de la Pitié-Salpêtrière

Paris, , France

Site Status

CHU Strasbourg Hôpital de Hautepierre

Strasbourg, , France

Site Status

Chu de Toulouse Hopital de La Grave

Toulouse, , France

Site Status

Praxis Dr. Erich Scholz

Böblingen, Baden-Wurttemberg, Germany

Site Status

ISPG - Institut für Studien zur psychischen Gesundheit

Mannheim, Baden-Wurttemberg, Germany

Site Status

Praxis für Neurologie und Psychiatrie Dr. med. Roth

Ostfildern, Baden-Wurttemberg, Germany

Site Status

Neurozentrum Sophienstraße

Stuttgart, Baden-Wurttemberg, Germany

Site Status

Klinikum der Universität München

München, Bavaria, Germany

Site Status

Klinikum Rechts der Isar der TU München

München, Bavaria, Germany

Site Status

Neuropraxis München Süd

Unterhaching, Bavaria, Germany

Site Status

Diakoniekrankenhaus Henriettenstiftung Hannover

Hanover, Lower Saxony, Germany

Site Status

MVZ LiO Berlin

Berlin, , Germany

Site Status

Policlinico Univ. Agostino Gemelli

Rome, Lazio, Italy

Site Status

Spedali Civili - Universita degli Studi

Brescia, , Italy

Site Status

Azienda Ospedaliera Universitaria Careggi

Florence, , Italy

Site Status

Ente Ospedaliero Ospedali Galliera

Genova, , Italy

Site Status

IRCCS Azienda Ospedaliera Universitaria San Martino

Genova, , Italy

Site Status

SDN - Istituto di Ricerca Diagnostica e Nucleare

Napoli, , Italy

Site Status

Azienda Ospedaliera - Universitaria Pisana

Pisa, , Italy

Site Status

IRCCS Santa Lucia

Roma, , Italy

Site Status

Universita La Sapienza

Roma, , Italy

Site Status

Azienda Ospedaliera Citta della Salute della Scienza Torino

Torino, , Italy

Site Status

Shinwakai Yachiyo Hospital

Anjo-shi, Aichi-ken, Japan

Site Status

Nagoya Ekisaikai Hospital

Nagoya, Aichi-ken, Japan

Site Status

Kojunkai Daido Hospital

Nagoya, Aichi-ken, Japan

Site Status

Inage Neurology and Memory Clinic

Chiba, Chiba, Japan

Site Status

Ehime University Hospital

Toon-Shi, Ehime, Japan

Site Status

Takeda General Hospital

Aizu-Wakamatsu, Fukushima, Japan

Site Status

Jisenkai Nanko Psychiatric Institute

Shirakawa-shi, Fukushima, Japan

Site Status

Koseikai Kusatsu Hospital

Hiroshima, Hiroshima, Japan

Site Status

NHO Hiroshima-Nishi Medical Center

Otaki-Shi, Hiroshima, Japan

Site Status

Yokohama Hospital

Yokohama, Kanagawa, Japan

Site Status

Koseikai Takeda Hospital

Kyoto, Kyoto, Japan

Site Status

Uji Takeda Hospital

Uji-Shi, Kyoto, Japan

Site Status

Nara Medical University Hospital

Kashihara, Nara, Japan

Site Status

JADECOM Nara City Hospital

Nara, Nara, Japan

Site Status

Oita University Hospital

Yufu-shi, Oita Prefecture, Japan

Site Status

Katayama Medical Clinic

Kurashiki-shi, Okayama-ken, Japan

Site Status

Himuro Neurology Clinic

Osaka, Osaka, Japan

Site Status

Kotobukikai Tominaga Clinic

Osaka, Osaka, Japan

Site Status

Kousaiin Hospital

Suita-shi, Osaka, Japan

Site Status

NHO Hizen Psychiatric Center

Kanzaki-gun, Saga-ken, Japan

Site Status

Shimizu Hospital

Shizuoka, Shizuoka, Japan

Site Status

Memory Clinic Ochanomizu

Bunkyo-ku, Tokyo, Japan

Site Status

Juntendo University Hospital

Bunkyo-ku, Tokyo, Japan

Site Status

Musashino Red Cross Hospital

Musashino, Tokyo, Japan

Site Status

Keikokai P-One Clinic

Hachioji-shi, Tokyo-To, Japan

Site Status

JOHAS Sanin Rosai Hospital

Yonago-shi, Tottori, Japan

Site Status

Aomori Prefectural Centeral Hospital

Aomori, , Japan

Site Status

Ikeuchi Psycho Induced Internal Clinic

Kobe, , Japan

Site Status

Yuge Hospital

Kumamoto, , Japan

Site Status

NHO Niigata Hospital

Niigata, , Japan

Site Status

NHO Hokkaido Medical Center

Sapporo, , Japan

Site Status

Hospital Universitario de Saltillo

Saltillo, Coahuila, Mexico

Site Status

Clinical Research Institute S C

Tlalnepantla, Edo de Mex, Mexico

Site Status

Mexico Centre for Clinical Research SA de CV

Mexico City, Mexico City, Mexico

Site Status

Hospital Univ. Jose Eleuterio Gonzalez

Monterrey, N.L., Mexico

Site Status

Accelerium Clinical Research

Monterrey, Nuevo León, Mexico

Site Status

Centro de Estudios Clinicos y Esp Medicas SC

Monterrey, Nuevo León, Mexico

Site Status

Avix Investigación Clínica, S.C

Monterrey, Nuevo León, Mexico

Site Status

Instituto de Informacion en Salud Mental (INFOSAM)

Monterrey, Nuevo León, Mexico

Site Status

Emotional Brain B.V.

Almere Stad, , Netherlands

Site Status

Brain Research Center

Amsterdam, , Netherlands

Site Status

Amphia Ziekenhuis

Breda, , Netherlands

Site Status

EB Utrecht

Utrecht, , Netherlands

Site Status

Isala Klinieken

Zwolle, , Netherlands

Site Status

NZOZ Wroclawskie Centrum Alzheimerowskie

Wroclaw, Lower Silesian Voivodeship, Poland

Site Status

Podlaskie Centrum Psychogeriatrii

Bialystok, Podlaskie Voivodeship, Poland

Site Status

Uniwersyteckie Centrum Kliniczne

Gdansk, Pomeranian Voivodeship, Poland

Site Status

NZOZ Mach-Med

Chorzów, , Poland

Site Status

Klinika Neurologii Neuro-Care

Katowice, , Poland

Site Status

Globe Badania Kliniczne SP Z O.O.

Kłodzko, , Poland

Site Status

Prywatny Gabinet Lekarski U.Chyrchel

Lublin, , Poland

Site Status

Centrum Medyczne Medyk

Rzeszów, , Poland

Site Status

Euromedis Sp. z o.o.

Szczecin, , Poland

Site Status

Clinsante Centrum Medyczne

Torun, , Poland

Site Status

Centrum Medyczne

Warsaw, , Poland

Site Status

Specjalistyczny Osrodek Medycyny Wieku Dojrzalego SOMED

Warsaw, , Poland

Site Status

Hospital Fernando Fonseca

Amadora, , Portugal

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Hospital de Braga

Braga, , Portugal

Site Status

Hospitals da Universidade de Coimbra

Coimbra, , Portugal

Site Status

SAIH Republ. Clinical Hospital of the MoH of Republ. Tatarst

Kazan', , Russia

Site Status

SIH Kemerovo Regional Clinical Hosptial

Kemerovo, , Russia

Site Status

FSBIH Siberian Clinical Center of FMBA

Krasnoyarsk, , Russia

Site Status

LLC City Neurological Centre Sibneuromed

Novosibirsk, , Russia

Site Status

Novosibirsk State Medical University

Novosibirsk, , Russia

Site Status

Ultramed

Omsk, , Russia

Site Status

LLC Treatment and Rehabilitation

Rostov-on-Don, , Russia

Site Status

Bekhterev Psyconeurological Institute

Saint Petersburg, , Russia

Site Status

Central Medical Sanitary Hospital #122

Saint Petersburg, , Russia

Site Status

RSBIH Smolensk Regional Clinical Hospital

Smolensk, , Russia

Site Status

Regional State Institution of Healthcare Tomsk Clinica Psych

Tomsk, , Russia

Site Status

Dong-A University Medical Center

Busan, Busan Gwang'yeogsi, South Korea

Site Status

The Catholic University of Korea-Bucheon St. Mary's Hospital

Bucheon-si, Gyeonggi-do, South Korea

Site Status

Myongji Hospital

Goyang-si, Gyeonggi-do, South Korea

Site Status

Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, South Korea

Site Status

Inha University Hospital

Incheon, , South Korea

Site Status

Korea University Anam Hospital

Seoul, , South Korea

Site Status

Seoul National University Hospital

Seoul, , South Korea

Site Status

Hanyang University Medical Center

Seoul, , South Korea

Site Status

Konkuk University Hospital

Seoul, , South Korea

Site Status

Samsung Medical Center

Seoul, , South Korea

Site Status

Hospital Cardiovascular San Vicente

San Vicent del Raspeig, Alicante, Spain

Site Status

Hospital General de Catalunya

Sant Cugat del Vallès, Barcelona, Spain

Site Status

Hospital Mutua de Terrassa

Terrassa, Barcelona, Spain

Site Status

Hospital Virgen Del Puerto

Plasencia, Caceres, Spain

Site Status

Policlinica Guipuzcoa

Donostia / San Sebastian, Guipuzcoa, Spain

Site Status

Hospital Ntra Sra Perpetuo Socorro

Albacete, , Spain

Site Status

Hospital del Mar

Barcelona, , Spain

Site Status

Fundacion ACE-Institut Catala de Neurociences Aplicades

Barcelona, , Spain

Site Status

Hospital Universitario La Fe de Valencia

Valencia, , Spain

Site Status

Cardinal Tien Hospital

Sindian City, Taipei, Taiwan

Site Status

National Taiwan University Hospital

Douliu, Yunlin County, Taiwan

Site Status

Changhua Christian Hospital

Changhua, , Taiwan

Site Status

Kaohsiung Medical University Chung-Ho Memorial Hospital

Kaohsiung City, , Taiwan

Site Status

Chang Gung Memorial Hospital - Kaohsiung

Kaohsiung City, , Taiwan

Site Status

Taipei Medical University- Shuang Ho Hospital

New Taipei City, , Taiwan

Site Status

National Cheng Kung University Hospital

Tainan City, , Taiwan

Site Status

Taipei Veterans General Hospital

Taipei, , Taiwan

Site Status

Chang Gung Memorial Hospital - Linkou

Taoyuan, , Taiwan

Site Status

Royal Devon and Exeter Hospital

Exeter, Devon, United Kingdom

Site Status

Re-Cognition Health Ltd

Plymouth, Devon, United Kingdom

Site Status

Charlton Lane Hospital

Cheltenham, Gloucestershire, United Kingdom

Site Status

Re-Cognition Health Ltd

Guildford, Surrey, United Kingdom

Site Status

Murray Royal Hospital

Perth, Tayside Region, United Kingdom

Site Status

Victoria Centre

Swindon, Wiltshire, United Kingdom

Site Status

Glasgow Memory Clinic

Glasgow, , United Kingdom

Site Status

Re-Cognition Health Ltd

London, , United Kingdom

Site Status

Countries

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United States Canada China Czechia Denmark France Germany Italy Japan Mexico Netherlands Poland Portugal Russia South Korea Spain Taiwan United Kingdom

References

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Wessels AM, Tariot PN, Zimmer JA, Selzler KJ, Bragg SM, Andersen SW, Landry J, Krull JH, Downing AM, Willis BA, Shcherbinin S, Mullen J, Barker P, Schumi J, Shering C, Matthews BR, Stern RA, Vellas B, Cohen S, MacSweeney E, Boada M, Sims JR. Efficacy and Safety of Lanabecestat for Treatment of Early and Mild Alzheimer Disease: The AMARANTH and DAYBREAK-ALZ Randomized Clinical Trials. JAMA Neurol. 2020 Feb 1;77(2):199-209. doi: 10.1001/jamaneurol.2019.3988.

Reference Type DERIVED
PMID: 31764959 (View on PubMed)

Cebers G, Alexander RC, Haeberlein SB, Han D, Goldwater R, Ereshefsky L, Olsson T, Ye N, Rosen L, Russell M, Maltby J, Eketjall S, Kugler AR. AZD3293: Pharmacokinetic and Pharmacodynamic Effects in Healthy Subjects and Patients with Alzheimer's Disease. J Alzheimers Dis. 2017;55(3):1039-1053. doi: 10.3233/JAD-160701.

Reference Type DERIVED
PMID: 27767991 (View on PubMed)

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

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Other Identifiers

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I8D-MC-AZET

Identifier Type: OTHER

Identifier Source: secondary_id

2015-005625-39

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

16024

Identifier Type: -

Identifier Source: org_study_id

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