Study to Evaluate the Efficacy and Safety of CKD-350

NCT ID: NCT02777723

Last Updated: 2016-05-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE3

Total Enrollment

138 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-05-31

Study Completion Date

2016-09-30

Brief Summary

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The purpose of this study is to compare the efficacy and safety of CKD-350 in patients with dry eye syndrome

Detailed Description

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Active controlled, randomized, double-blind, multi-center, phase 3 trial to evaluate the efficacy and safety of CKD-350 eye drops in patients with dry eye syndrome

Conditions

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Dry Eye Syndrome

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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CKD-350

Xenobella

Group Type EXPERIMENTAL

Xenobella

Intervention Type DRUG

Hypotonic 0.3% Sodium Hyaluronate

Sodium Hyaluronate

Isotonic 0.3% Sodium Hyaluronate

Group Type ACTIVE_COMPARATOR

Isotonic 0.3% Sodium Hyaluronate

Intervention Type DRUG

Isotonic 0.3% Sodium Hyaluronate

Interventions

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Xenobella

Hypotonic 0.3% Sodium Hyaluronate

Intervention Type DRUG

Isotonic 0.3% Sodium Hyaluronate

Isotonic 0.3% Sodium Hyaluronate

Intervention Type DRUG

Other Intervention Names

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Arm A Arm B

Eligibility Criteria

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Inclusion Criteria

1. More than the age of 19 years old
2. Subjects with dry eye symptoms for at least 3 month prior to screening
3. Subjects who have following values 1) ≥ 2 point of corneal staining score 2) ≤ 10 seconds of Tear Break-up Time 3) ≤10mm/5min of Schirmer I Test
4. Subjects who have a visual acuity equal to or better than 0.2 in both eyes
5. Subjects who sign on an informed consent form willingly

Exclusion Criteria

1. Subjects who have clinically significant ocular surface diseases, abnormal corneal susceptibility and abnormal epiphora
2. Subjects who have medical history following 1) Abnormal eyelids function including abnormality of eyelid or eyelash 2) Ophthalmology operation within 1 year 3) Active ocular infection at present or treatment of allergic eye diseases 4) Herpetic keratopathy, conjunctiva scar from cicatricial keratoconjunctivitis(alkali injuries, stevens-johnson syndrome, ocular cicatricial pemphigoid), pterygium, congenital lacrimal gland absence, neural keratitis, keratoconus
3. Subjects who have received occlusion therapy with lacrimal or punctal plugs within 3 months or have a surgery plan in clinical trial
4. Subjects who wore contact lenses within 3 months or need to wear contact lenses during the study
5. Subjects who take steroidal or immunosuppressive drug within 1 month
6. Over 22mmHg IOP(Intraocular Pressure)
7. Subjects who have malignant tumor within 5 years
8. Subjects with known hypersensitivity to investigational product
9. Women who are nursing, pregnant or planning pregnancy during the study
10. Subjects who have received any other investigational product within 1 month prior to the first dosing
11. Impossible subjects who participate in clinical trial by investigator's decision
Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Chong Kun Dang Pharmaceutical

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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HyoMyung Kim, MD

Role: STUDY_CHAIR

Korea University Anam Hospital

Locations

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Chungnam National University Hospital

Daejeon, Chungcheongnam-do, South Korea

Site Status NOT_YET_RECRUITING

Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, South Korea

Site Status RECRUITING

Kyungpook National University Hospital

Daegu, Gyeongsangbuk-do, South Korea

Site Status RECRUITING

Pusan National University Hospital

Pusan, Gyeongsangnam-do, South Korea

Site Status RECRUITING

Chonbuk National University Hospital

Jeonju, Jeollabuk-do, South Korea

Site Status RECRUITING

Chonnam National University Hospital

Gwangju, Jeollanam-do, South Korea

Site Status RECRUITING

Asan Medical Center

Seoul, Seoul, South Korea

Site Status RECRUITING

Gangnam Severance Hospital

Seoul, Seoul, South Korea

Site Status NOT_YET_RECRUITING

Korea University ANAM Hospital

Seoul, Seoul, South Korea

Site Status RECRUITING

Korea University GURO Hospital

Seoul, Seoul, South Korea

Site Status RECRUITING

Samsung Medical Center

Seoul, Seoul, South Korea

Site Status RECRUITING

Seoul National University Hospital

Seoul, Seoul, South Korea

Site Status NOT_YET_RECRUITING

The Catholic University of Korea Seoul ST. MARY'S Hospital

Seoul, Seoul, South Korea

Site Status RECRUITING

Yonsei University Severance Hospital

Seoul, Seoul, South Korea

Site Status RECRUITING

Countries

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South Korea

Facility Contacts

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SiHwan Choi, MD

Role: primary

82-10-5427-7609

JoonYoung Hyon, MD

Role: primary

82-10-2735-8123

HongKyun Kim, MD

Role: primary

82-10-4509-4886

JongSu Lee, MD

Role: primary

82-10-9021-2498

InChun You, MD

Role: primary

82-10-3292-1824

KyungChul Yoon, MD

Role: primary

82-10-9220-0234

HungWon Tchah, MD

Role: primary

82-10-8177-8000

HyungKeun Lee, MD

Role: primary

82-10-6202-7164

HyoMyoung Kim, MD

Role: primary

82-10-5415-5776

JongSeok Song, MD

Role: primary

82-10-9494-1606

TaeYoung Chung, MD

Role: primary

82-10-9933-3563

MeeKum Kim, MD

Role: primary

82-10-6277-0798

SoHyang Chung, MD

Role: primary

82-10-6313-6202

TaeIm Kim, MD

Role: primary

82-10-6309-9639

Other Identifiers

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164DES16001

Identifier Type: -

Identifier Source: org_study_id

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