Comparing a Randomised Controlled Intervention With Observational Data.

NCT ID: NCT02763501

Last Updated: 2016-10-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

10992 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-05-31

Study Completion Date

2016-05-31

Brief Summary

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Comparison of participants in a randomised controlled trial (RCT) with observational data from patients operated in Sweden during the same period of time. The primary objective is to compare effects from a complex surgical intervention from RCT and observational data.

Detailed Description

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Randomised controlled trials (RCT) are "golden standard" for assessing interventions in medical science. Due to ethical or practical reasons, RCTs may however not always be feasible. The study objective was to test if the results from the RCT differ from observational data in a setting with a complex surgical intervention.

Using the Scandinavian Obesity Surgery Registry database we intend to compare patients operated with laparoscopic gastric bypass surgery within a register based RCT from May 1st 2010 until Nov 14th 2011, with all patients operated with the same procedure registered in the database during the same period of time.

Primary end-point measures are severe complications within 30 days (safety outcome) and surgery for small bowel obstruction (efficacy outcome) within 4 years.

Conditions

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Obesity, Morbid

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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RCT

patients operated with laparoscopic gastric bypass surgery within a register based RCT from May 1st 2010 until Nov 14th 2011.

1:1 randomization to closure of mesenteric defects by running, non-absorbable sutures

Group Type ACTIVE_COMPARATOR

closure of mesenteric defects

Intervention Type PROCEDURE

Closure of mesenteric defects by use of non-absorbable running sutures in RCT; and according to the choice of the surgeon in the non-RCT

non-closure of mesenteric defects

Intervention Type PROCEDURE

Mesenteric defects are left open

non-RCT

patients operated with laparoscopic gastric bypass surgery outside of the RCT from May 1st 2010 until Nov 14th 2011.

Intervention of mesenteric defects according to local tradition or choice of surgeon (non-randomized)

Group Type ACTIVE_COMPARATOR

closure of mesenteric defects

Intervention Type PROCEDURE

Closure of mesenteric defects by use of non-absorbable running sutures in RCT; and according to the choice of the surgeon in the non-RCT

non-closure of mesenteric defects

Intervention Type PROCEDURE

Mesenteric defects are left open

Interventions

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closure of mesenteric defects

Closure of mesenteric defects by use of non-absorbable running sutures in RCT; and according to the choice of the surgeon in the non-RCT

Intervention Type PROCEDURE

non-closure of mesenteric defects

Mesenteric defects are left open

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* The same as acceptance criteria for bariatric surgery according to the 1991 NIH Consensus Statement

Exclusion Criteria

* retrocolic gastric bypass procedure
* previous bariatric procedures
* primary open procedures
* missing data on handling of the mesenteric defects
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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The Scandinavian Obesity Surgery Registry

UNKNOWN

Sponsor Role collaborator

Region Örebro County

OTHER

Sponsor Role lead

Responsible Party

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Erik Stenberg, MD

DR

Responsibility Role PRINCIPAL_INVESTIGATOR

Related Links

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http://www.ucr.uu.se/soreg

The Scandinavian Obesity Surgery Registry

Other Identifiers

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EPN 2015/097

Identifier Type: -

Identifier Source: org_study_id

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