Using SMART Design to Improve Symptom Management Strategies Among Cancer Patients

NCT ID: NCT02759146

Last Updated: 2020-12-16

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

347 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-05-31

Study Completion Date

2019-11-30

Brief Summary

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The purpose of this study is to compare reflexology to meditative practices to reduce symptoms in cancer patients.

Detailed Description

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First, dyads were randomized to receive caregiver-delivered reflexology or meditative practice. Fatigue severity was assesses weekly via phone calls to the cancer patients during weeks 1-4 of the intervention. For patients who did not respond to the intervention during the first 4 weeks, those dyads were referred to as non-responder and re-randomized. A non-responder was determined if the level of reported fatigue remained the same or increased from the first week of the intervention.

The re-randomization placed the non-responders in either a group that received a higher dose (more time) with the first intervention or to the alternate practice (meditative practice to those randomized to reflexology and vice versa) for weeks 5-8. Those who did respond during weeks 1-4 continued the same therapy they began with.

Conditions

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Cancer

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

SINGLE

Investigators

Study Groups

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Reflexology

Reflexology is a specialized foot therapy that applies a firm walking motion pressure to the feet. It is based on the premise that the foot has reflexes that mirror the rest of the body. It has been shown to reduce symptoms.

Group Type EXPERIMENTAL

Reflexology

Intervention Type OTHER

Reflexology is a specialized foot therapy that applies a firm walking motion pressure to the feet. It is based on the premise that the foot has reflexes that mirror the rest of the body. It has been shown to reduce symptoms.

Meditative Practice

Meditative Practices include elements of meditation, gentle yoga and breathing exercises. These practices focus purposeful attention to the present moment and have been shown to enhance one's ability to adapt to serious health concerns

Group Type EXPERIMENTAL

Meditative Practices

Intervention Type OTHER

Meditative Practices include elements of meditation, gentle yoga and breathing exercises. These practices focus purposeful attention to the present moment and have been shown to enhance one's ability to adapt to serious health concerns

Control

Control - no intervention

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Reflexology

Reflexology is a specialized foot therapy that applies a firm walking motion pressure to the feet. It is based on the premise that the foot has reflexes that mirror the rest of the body. It has been shown to reduce symptoms.

Intervention Type OTHER

Meditative Practices

Meditative Practices include elements of meditation, gentle yoga and breathing exercises. These practices focus purposeful attention to the present moment and have been shown to enhance one's ability to adapt to serious health concerns

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* 21 year of age or older
* Solid tumor cancer diagnosis
* Able to perform basic activities of daily living (ADLs)
* Undergoing chemotherapy, hormonal therapy, or targeted therapy
* Able to speak and understand English
* Have access to a telephone
* Able to hear normal conversation
* Reporting a severity of 3 or higher on fatigue using a 0-10 standardized scale at intake.

Exclusion Criteria

* Diagnosis of major mental illness on the medical record (verified by the recruiter)
* Residing in a nursing home
* Bedridden
* Currently receiving reflexology or meditative practices
* Suspected or diagnosed deep vein thrombosis or painful foot neuropathy.
Minimum Eligible Age

21 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Cancer Institute (NCI)

NIH

Sponsor Role collaborator

Michigan State University

OTHER

Sponsor Role lead

Responsible Party

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Gwen Wyatt

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Gwen Wyatt, PhD, RN

Role: PRINCIPAL_INVESTIGATOR

Michigan State University College of Nursing

Locations

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Arizona Oncology

Tucson, Arizona, United States

Site Status

University of Arizona

Tucson, Arizona, United States

Site Status

Northwestern University

Chicago, Illinois, United States

Site Status

Karmanos Cancer Institute

Detroit, Michigan, United States

Site Status

Cancer & Hematology Centers of Western Michigan

Grand Rapids, Michigan, United States

Site Status

MSU Breslin Cancer Center

Lansing, Michigan, United States

Site Status

Sparrow Cancer Center

Lansing, Michigan, United States

Site Status

Countries

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United States

References

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Thana K, Sikorskii A, Lehto R, Guhaniyogi P, Brewer S, Victorson D, Pace T, Badger T, Wyatt G. Family caregivers of those with cancer: quality of life outcomes from a sequential multiple assignment randomized trial. Support Care Cancer. 2022 Jul;30(7):5891-5902. doi: 10.1007/s00520-022-07012-7. Epub 2022 Apr 5.

Reference Type DERIVED
PMID: 35378595 (View on PubMed)

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

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R01CA193706

Identifier Type: NIH

Identifier Source: secondary_id

View Link

PA13-165

Identifier Type: -

Identifier Source: org_study_id