Determination of Accuracy in Measurement of Total Immunoglobulin E Using a Test Device in Atopic Subjects

NCT ID: NCT02758548

Last Updated: 2016-11-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

193 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-03-31

Study Completion Date

2016-05-31

Brief Summary

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The purpose of this study is to determine the accuracy of the Novel point of care test (POCT) total IgE assay in atopic patients.

120 patients with atopic conditions and approximately 40 healthy subjects will be enrolled. Fingerstick capillary blood samples will be collected and tested in the POCT device. Venous samples will be collected and sent to a reference laboratory for measurement of serum total IgE using the reference immunoassay method.

Detailed Description

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Conditions

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Atopic Asthma

Keywords

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Total IgE measurement Novel Point-of-care test device atopic conditions in vitro diagnostic test

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Capillary Blood Sampling

Capillary blood sampling, collected as two fingerprick samples with POCT device and two venous samples

Group Type OTHER

Blood sample

Intervention Type PROCEDURE

Fingerprick and venous

POCT device

Intervention Type DEVICE

Investigational device

Interventions

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Blood sample

Fingerprick and venous

Intervention Type PROCEDURE

POCT device

Investigational device

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Subjects who are diagnosed with atopic condition
* Subjects or legal guardians who are able to give informed consent
* Subjects who have received anti-IgE antibody treatment
* Subjects who have elevated IgE levels for reasons other than allergic conditions
* Subjects who are able to give informed consent for participation in the study according to local requirements / law.

Exclusion Criteria

* Subjects who have received anti-IgE antibody treatment
* Subjects with a suspected or confirmed clinical diagnosis of an atopic condition
Minimum Eligible Age

6 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Novartis Pharmaceuticals

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Novartis Investigative Site

Hamburg, , Germany

Site Status

Novartis Investigative Site

Lübeck, , Germany

Site Status

Novartis Investigative Site

Padua, PD, Italy

Site Status

Novartis Investigative Site

Pisa, PI, Italy

Site Status

Novartis Investigative Site

Roma, RM, Italy

Site Status

Novartis Investigative Site

Harderwijk, Netherlands, Netherlands

Site Status

Novartis Investigative Site

Almelo, , Netherlands

Site Status

Novartis Investigative Site

Sabadell, Barcelona, Spain

Site Status

Novartis Investigative Site

Valencia, Valencia, Spain

Site Status

Novartis Investigative Site

Chertsey, Surrey, United Kingdom

Site Status

Novartis Investigative Site

Bradford, West Yorkshire, United Kingdom

Site Status

Novartis Investigative Site

Manchester, , United Kingdom

Site Status

Countries

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Germany Italy Netherlands Spain United Kingdom

Other Identifiers

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CDIGE0012201

Identifier Type: -

Identifier Source: org_study_id