Effects of EED on Zn Absorption and Retention in Children From a MNP
NCT ID: NCT02758444
Last Updated: 2019-07-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
80 participants
INTERVENTIONAL
2015-11-30
2019-02-28
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
QUADRUPLE
Study Groups
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Micronutrient Powder (MNP) + 15 mg Zn
1 sachet of Micronutrient Powder (MNP) + 15 mg Zn will be added to a single meal on study day 8
Micronutrient Powder (MNP) + 15 mg Zn
Children will have the supplement powder added to one meal on study day 1. Absorption of zinc from this meal will be measured using zinc stable isotope techniques.
MNP + 10 mg Zn
1 sachet of MNP + 10 mg Zn will be added to a single meal on study day 8
MNP + 10 mg Zn
Same as above except MNP will contain 10 mg Zn
MNP + 5 mg Zn
1 sachet of MNP + 5 mg Zn will be added to a single meal on study day 8
MNP + 5 mg Zn
Same as above except MNP will contain 5 mg Zn
MNP without Zn
1 sachet of MNP without Zn will be added to a single meal on study day 8
MNP without Zn
Same as above except MNP will not contain Zn
Interventions
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Micronutrient Powder (MNP) + 15 mg Zn
Children will have the supplement powder added to one meal on study day 1. Absorption of zinc from this meal will be measured using zinc stable isotope techniques.
MNP + 10 mg Zn
Same as above except MNP will contain 10 mg Zn
MNP + 5 mg Zn
Same as above except MNP will contain 5 mg Zn
MNP without Zn
Same as above except MNP will not contain Zn
Eligibility Criteria
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Inclusion Criteria
* Length for age Z (LAZ) score between -1.5 to -3.0
* Hg ≥ 8
Exclusion Criteria
* Hb \< 8
* Chronic illness
* Zinc supplement within past 2 weeks (including for treatment of diarrhea or MNP containing zinc)
* Severe stunting and/or severe acute malnutrition (SAM): LAZ \<-3; WHZ \<-3 or MUAC \< 115 or edema
18 Months
24 Months
ALL
Yes
Sponsors
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International Centre for Diarrhoeal Disease Research, Bangladesh
OTHER
University of Colorado, Denver
OTHER
Responsible Party
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Principal Investigators
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Nancy F Krebs, MD, MS
Role: PRINCIPAL_INVESTIGATOR
University of Colorado, Denver
Locations
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University of Colorado Denver
Aurora, Colorado, United States
icddr,b (International Centre for Diarrheal Disease Research, Bangladesh
Dhaka, , Bangladesh
Countries
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References
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Long JM, Mondal P, Westcott JE, Miller LV, Islam MM, Ahmed M, Mahfuz M, Ahmed T, Krebs NF. Zinc Absorption from Micronutrient Powders Is Low in Bangladeshi Toddlers at Risk of Environmental Enteric Dysfunction and May Increase Dietary Zinc Requirements. J Nutr. 2019 Jan 1;149(1):98-105. doi: 10.1093/jn/nxy245.
Other Identifiers
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14-2430B
Identifier Type: -
Identifier Source: org_study_id
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