BK Virus Post-Kidney Transplant: New Practice Versus Traditional Approach
NCT ID: NCT02758288
Last Updated: 2020-10-05
Study Results
Results pending
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
Recruitment Status
WITHDRAWN
Study Classification
OBSERVATIONAL
Study Start Date
2015-09-30
Study Completion Date
2022-07-31
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
The investigator's aim in this study is to evaluate the impact of a new standard of care protocol for the treatment of BK viremia and nephropathy (BKVAN), which includes switching from Tacrolimus to equivalent dose of Cyclosporine in patients who have been diagnosed with BK viremia or BKVAN based on their viral load, overall graft function (estimated glomerular filtration rate), acute rejection, and rate of graft loss due to rejection or BKVAN.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Safety, Tolerability and Efficacy of AntiBKV as Treatment of BKV Infection in Kidney Transplant Recipients
NCT05769582
BK Viremia; BKV DNAemia
COMPLETED
PHASE2/PHASE3
Cidofovir in Renal Transplant Recipients With BKVN
NCT00138424
BK Virus (Nephropathy)
TERMINATED
PHASE1/PHASE2
Studying the Effect of Changing Immunosuppression in Case of Polyoma BK Virus Infection of the Renal Transplant
NCT01289301
Disorder Related to Renal Transplantation
Immunosuppression Related Infectious Disease
Virus Diseases
UNKNOWN
PHASE4
Using mTOR Inhibitors in the Prevention of BK Nephropathy
NCT01649609
BK Viremia
BK Nephropathy
COMPLETED
NA
Multicenter Randomized Two-arms Study Evaluating the BK Viral Clearance in Kidney Transplant Recipients With BK Viremia.
NCT03216967
BK Virus Nephropathy After Kidney Transplantation
COMPLETED
PHASE4
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
This study will be a combined retrospective chart review and prospective observational study. This will be a single center project that will take place at Loma Linda University Transplant Institute. All adult kidney recipients who are determined to have BK viremia with a BK PCR viral load over 500 copy post-transplant and meet the inclusion criteria but no exclusion criteria will be enrolled and observed per study protocol.
All kidney transplant recipients are routinely assessed for BK virus nephropathy and viremia post transplant as part of their standard care. Patients with BK viremia or BK virus nephropathy will have adjustments in their immunosuppressive medication based on current guidelines and recommendations which include reduction in immunosuppression, treatment with medications with antiviral activity (Cidofovir, Ciprofloxacin, Leflunomide, IVIG) or switching from a Tacrolimus (Prograf)-based regimen to a Cyclosporine-based regimen. Retrospectively, the investigator will collect data on patients who have been diagnosed with BK viremia or BK virus nephropathy and have had such a management in past 66 months (from 1/1/2010 till 06/30/2015). Prospectively, the investigator will enroll and collect data on patients who will be treated for BK viremia or BK virus nephropathy.
As standard of care, all kidney transplant recipients will be seen routinely on weekly-biweekly basis in post-transplant clinic for up to 3 months then every 3 months for up to a year and yearly thereafter. All kidney transplant recipients will be monitored for BK viremia by having blood PCR tested on a monthly basis at 1, 2, 3, 6, and 12 months after transplant. Also, all patients post-kidney transplant will be tested for BK viremia if there is an acute rise in their creatinine.
All kidney transplant recipients are routinely assessed for BK virus nephropathy and viremia post transplant as part of their standard care. Patients with BK viremia or BK virus nephropathy will have adjustments in their immunosuppressive medication based on current guidelines and recommendations which include reduction in immunosuppression, treatment with medications with antiviral activity (Cidofovir, Ciprofloxacin, Leflunomide, IVIG) or switching from a Tacrolimus (Prograf)-based regimen to a Cyclosporine-based regimen. Retrospectively, the investigator will collect data on patients who have been diagnosed with BK viremia or BK virus nephropathy and have had such a management in past 66 months (from 1/1/2010 till 06/30/2015). Prospectively, the investigator will enroll and collect data on patients who will be treated for BK viremia or BK virus nephropathy.
As standard of care, all kidney transplant recipients will be seen routinely on weekly-biweekly basis in post-transplant clinic for up to 3 months then every 3 months for up to a year and yearly thereafter. All kidney transplant recipients will be monitored for BK viremia by having blood PCR tested on a monthly basis at 1, 2, 3, 6, and 12 months after transplant. Also, all patients post-kidney transplant will be tested for BK viremia if there is an acute rise in their creatinine.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
BK Virus Infection
BK Virus Nephropathy
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
Observational Model Type
OTHER
Study Time Perspective
PROSPECTIVE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
New Protocol to treat BK viremia or BKVAN
Adult kidney recipients who are determined to have BK viremia with a BK PCR viral load over 500 copy post-transplant treated with a new treatment protocol, prospective data collection approach
New Protocol - BK viremia or BK virus nephropathy
Intervention Type
OTHER
Data collected prospectively that will follow new clinical practice guidelines that were developed by Loma Linda Nephrology group with collaboration with Transplant surgeons to improve care of patients complicated with BK viremia or BK virus nephropathy.
Standard Protocol to treat BK viremia or BKVAN
Adult kidney recipients who are determined to have BK viremia with a BK PCR viral load over 500 copy post-transplant treated with a traditional standard of care protocol, retrospective data collection approach
Standard Protocol - BK viremia or BK virus nephropathy
Intervention Type
OTHER
Data collected retrospectively that followed standard clinical practice guidelines that were developed by Loma Linda Nephrology group with collaboration with Transplant surgeons to improve care of patients complicated with BK viremia or BK virus nephropathy.
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
New Protocol - BK viremia or BK virus nephropathy
Data collected prospectively that will follow new clinical practice guidelines that were developed by Loma Linda Nephrology group with collaboration with Transplant surgeons to improve care of patients complicated with BK viremia or BK virus nephropathy.
Intervention Type
OTHER
Standard Protocol - BK viremia or BK virus nephropathy
Data collected retrospectively that followed standard clinical practice guidelines that were developed by Loma Linda Nephrology group with collaboration with Transplant surgeons to improve care of patients complicated with BK viremia or BK virus nephropathy.
Intervention Type
OTHER
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* Age ≥ 18 years
* Recipient of kidney or combined kidney and pancreas
* BK viremia confirmed with blood PCR test with viral load over 500
* BK virus nephropathy confirmed by kidney biopsy
* Recipient of kidney or combined kidney and pancreas
* BK viremia confirmed with blood PCR test with viral load over 500
* BK virus nephropathy confirmed by kidney biopsy
Exclusion Criteria
* Recipient of combined organ transplant except kidney and pancreases
* Patient age \< 18 years
* If patient does not consent for kidney biopsy
* Currently on treatment for acute rejection
* Patients with HIV, Hep C or Hep B infection
* Patients who are on other immunosuppression beside our standard regimen which includes Prograf, cellcept / Myfortic and prednisone
* Patient age \< 18 years
* If patient does not consent for kidney biopsy
* Currently on treatment for acute rejection
* Patients with HIV, Hep C or Hep B infection
* Patients who are on other immunosuppression beside our standard regimen which includes Prograf, cellcept / Myfortic and prednisone
Minimum Eligible Age
18 Years
Eligible Sex
ALL
Accepts Healthy Volunteers
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Loma Linda University
OTHER
Sponsor Role
lead
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Amir Abdipour, MD
Assistant Professor of Medicine
Responsibility Role
PRINCIPAL_INVESTIGATOR
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Amir Abdipour, MD
Role: PRINCIPAL_INVESTIGATOR
Loma Linda University Health
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Loma Linda University Medical Center
Loma Linda, California, United States
Site Status
Countries
Review the countries where the study has at least one active or historical site.
United States
References
Explore related publications, articles, or registry entries linked to this study.
Tonelli M, Wiebe N, Knoll G, Bello A, Browne S, Jadhav D, Klarenbach S, Gill J. Systematic review: kidney transplantation compared with dialysis in clinically relevant outcomes. Am J Transplant. 2011 Oct;11(10):2093-109. doi: 10.1111/j.1600-6143.2011.03686.x. Epub 2011 Aug 30.
Reference Type
BACKGROUND
Port FK, Wolfe RA, Mauger EA, Berling DP, Jiang K. Comparison of survival probabilities for dialysis patients vs cadaveric renal transplant recipients. JAMA. 1993 Sep 15;270(11):1339-43.
Reference Type
BACKGROUND
Schnuelle P, Lorenz D, Trede M, Van Der Woude FJ. Impact of renal cadaveric transplantation on survival in end-stage renal failure: evidence for reduced mortality risk compared with hemodialysis during long-term follow-up. J Am Soc Nephrol. 1998 Nov;9(11):2135-41. doi: 10.1681/ASN.V9112135.
Reference Type
BACKGROUND
Padgett BL, Walker DL. Prevalence of antibodies in human sera against JC virus, an isolate from a case of progressive multifocal leukoencephalopathy. J Infect Dis. 1973 Apr;127(4):467-70. doi: 10.1093/infdis/127.4.467. No abstract available.
Reference Type
BACKGROUND
Bressollette-Bodin C, Coste-Burel M, Hourmant M, Sebille V, Andre-Garnier E, Imbert-Marcille BM. A prospective longitudinal study of BK virus infection in 104 renal transplant recipients. Am J Transplant. 2005 Aug;5(8):1926-33. doi: 10.1111/j.1600-6143.2005.00934.x.
Reference Type
BACKGROUND
Ginevri F, Azzi A, Hirsch HH, Basso S, Fontana I, Cioni M, Bodaghi S, Salotti V, Rinieri A, Botti G, Perfumo F, Locatelli F, Comoli P. Prospective monitoring of polyomavirus BK replication and impact of pre-emptive intervention in pediatric kidney recipients. Am J Transplant. 2007 Dec;7(12):2727-35. doi: 10.1111/j.1600-6143.2007.01984.x. Epub 2007 Oct 1.
Reference Type
BACKGROUND
Brennan DC, Agha I, Bohl DL, Schnitzler MA, Hardinger KL, Lockwood M, Torrence S, Schuessler R, Roby T, Gaudreault-Keener M, Storch GA. Incidence of BK with tacrolimus versus cyclosporine and impact of preemptive immunosuppression reduction. Am J Transplant. 2005 Mar;5(3):582-94. doi: 10.1111/j.1600-6143.2005.00742.x.
Reference Type
BACKGROUND
Kadambi PV, Josephson MA, Williams J, Corey L, Jerome KR, Meehan SM, Limaye AP. Treatment of refractory BK virus-associated nephropathy with cidofovir. Am J Transplant. 2003 Feb;3(2):186-91. doi: 10.1034/j.1600-6143.2003.30202.x.
Reference Type
BACKGROUND
Moscarelli L, Caroti L, Antognoli G, Zanazzi M, Di Maria L, Carta P, Minetti E. Everolimus leads to a lower risk of BKV viremia than mycophenolic acid in de novo renal transplantation patients: a single-center experience. Clin Transplant. 2013 Jul-Aug;27(4):546-54. doi: 10.1111/ctr.12151. Epub 2013 Jun 13.
Reference Type
BACKGROUND
Araya CE, Garin EH, Neiberger RE, Dharnidharka VR. Leflunomide therapy for BK virus allograft nephropathy in pediatric and young adult kidney transplant recipients. Pediatr Transplant. 2010 Feb;14(1):145-50. doi: 10.1111/j.1399-3046.2009.01183.x. Epub 2009 Mar 31.
Reference Type
BACKGROUND
Williams JW, Javaid B, Kadambi PV, Gillen D, Harland R, Thistlewaite JR, Garfinkel M, Foster P, Atwood W, Millis JM, Meehan SM, Josephson MA. Leflunomide for polyomavirus type BK nephropathy. N Engl J Med. 2005 Mar 17;352(11):1157-8. doi: 10.1056/NEJM200503173521125. No abstract available.
Reference Type
BACKGROUND
Leung AY, Chan MT, Yuen KY, Cheng VC, Chan KH, Wong CL, Liang R, Lie AK, Kwong YL. Ciprofloxacin decreased polyoma BK virus load in patients who underwent allogeneic hematopoietic stem cell transplantation. Clin Infect Dis. 2005 Feb 15;40(4):528-37. doi: 10.1086/427291. Epub 2005 Jan 21.
Reference Type
BACKGROUND
Randhawa PS. Anti-BK virus activity of ciprofloxacin and related antibiotics. Clin Infect Dis. 2005 Nov 1;41(9):1366-7; author reply 1367. doi: 10.1086/497080. No abstract available.
Reference Type
BACKGROUND
Hirsch HH, Vincenti F, Friman S, Tuncer M, Citterio F, Wiecek A, Scheuermann EH, Klinger M, Russ G, Pescovitz MD, Prestele H. Polyomavirus BK replication in de novo kidney transplant patients receiving tacrolimus or cyclosporine: a prospective, randomized, multicenter study. Am J Transplant. 2013 Jan;13(1):136-45. doi: 10.1111/j.1600-6143.2012.04320.x. Epub 2012 Nov 8.
Reference Type
BACKGROUND
Renner FC, Dietrich H, Bulut N, Celik D, Freitag E, Gaertner N, Karoui S, Mark J, Raatz C, Weimer R, Feustel A. The risk of polyomavirus-associated graft nephropathy is increased by a combined suppression of CD8 and CD4 cell-dependent immune effects. Transplant Proc. 2013 May;45(4):1608-10. doi: 10.1016/j.transproceed.2013.01.026.
Reference Type
BACKGROUND
Huang G, Chen LZ, Qiu J, Wang CX, Fei JG, Deng SX, Li J, Chen GD, Zhang L, Fu Q, Zeng WT, Zhao DQ. Prospective study of polyomavirus BK replication and nephropathy in renal transplant recipients in China: a single-center analysis of incidence, reduction in immunosuppression and clinical course. Clin Transplant. 2010 Sep-Oct;24(5):599-609. doi: 10.1111/j.1399-0012.2009.01141.x.
Reference Type
BACKGROUND
Knoll GA, Bell RC. Tacrolimus versus cyclosporin for immunosuppression in renal transplantation: meta-analysis of randomised trials. BMJ. 1999 Apr 24;318(7191):1104-7. doi: 10.1136/bmj.318.7191.1104.
Reference Type
BACKGROUND
Alghamdi S, Nabi Z, Skolnik E, Alkorbi L, Albaqumi M. Cyclosporine versus tacrolimus maintenance therapy in renal transplant. Exp Clin Transplant. 2011 Jun;9(3):170-4.
Reference Type
BACKGROUND
Gardner SD, Field AM, Coleman DV, Hulme B. New human papovavirus (B.K.) isolated from urine after renal transplantation. Lancet. 1971 Jun 19;1(7712):1253-7. doi: 10.1016/s0140-6736(71)91776-4. No abstract available.
Reference Type
BACKGROUND
Boothpur R, Brennan DC. Human polyoma viruses and disease with emphasis on clinical BK and JC. J Clin Virol. 2010 Apr;47(4):306-12. doi: 10.1016/j.jcv.2009.12.006. Epub 2010 Jan 8.
Reference Type
BACKGROUND
Elphick GF, Querbes W, Jordan JA, Gee GV, Eash S, Manley K, Dugan A, Stanifer M, Bhatnagar A, Kroeze WK, Roth BL, Atwood WJ. The human polyomavirus, JCV, uses serotonin receptors to infect cells. Science. 2004 Nov 19;306(5700):1380-3. doi: 10.1126/science.1103492.
Reference Type
BACKGROUND
Monaco MC, Jensen PN, Hou J, Durham LC, Major EO. Detection of JC virus DNA in human tonsil tissue: evidence for site of initial viral infection. J Virol. 1998 Dec;72(12):9918-23. doi: 10.1128/JVI.72.12.9918-9923.1998.
Reference Type
BACKGROUND
Rinaldo CH, Tylden GD, Sharma BN. The human polyomavirus BK (BKPyV): virological background and clinical implications. APMIS. 2013 Aug;121(8):728-45. doi: 10.1111/apm.12134. Epub 2013 Jun 19.
Reference Type
BACKGROUND
Balba GP, Javaid B, Timpone JG Jr. BK polyomavirus infection in the renal transplant recipient. Infect Dis Clin North Am. 2013 Jun;27(2):271-83. doi: 10.1016/j.idc.2013.02.002. Epub 2013 Apr 17.
Reference Type
BACKGROUND
Nickeleit V, Klimkait T, Binet IF, Dalquen P, Del Zenero V, Thiel G, Mihatsch MJ, Hirsch HH. Testing for polyomavirus type BK DNA in plasma to identify renal-allograft recipients with viral nephropathy. N Engl J Med. 2000 May 4;342(18):1309-15. doi: 10.1056/NEJM200005043421802.
Reference Type
BACKGROUND
Vasudev B, Hariharan S, Hussain SA, Zhu YR, Bresnahan BA, Cohen EP. BK virus nephritis: risk factors, timing, and outcome in renal transplant recipients. Kidney Int. 2005 Oct;68(4):1834-9. doi: 10.1111/j.1523-1755.2005.00602.x.
Reference Type
BACKGROUND
Randhawa P, Ho A, Shapiro R, Vats A, Swalsky P, Finkelstein S, Uhrmacher J, Weck K. Correlates of quantitative measurement of BK polyomavirus (BKV) DNA with clinical course of BKV infection in renal transplant patients. J Clin Microbiol. 2004 Mar;42(3):1176-80. doi: 10.1128/JCM.42.3.1176-1180.2004.
Reference Type
BACKGROUND
Kahan AV, Coleman DV, Koss LG. Activation of human polyomavirus infection-detection by cytologic technics. Am J Clin Pathol. 1980 Sep;74(3):326-32. doi: 10.1093/ajcp/74.3.326.
Reference Type
BACKGROUND
Hirsch HH, Randhawa P; AST Infectious Diseases Community of Practice. BK virus in solid organ transplant recipients. Am J Transplant. 2009 Dec;9 Suppl 4:S136-46. doi: 10.1111/j.1600-6143.2009.02904.x. No abstract available.
Reference Type
BACKGROUND
Hariharan S. BK virus nephritis after renal transplantation. Kidney Int. 2006 Feb;69(4):655-62. doi: 10.1038/sj.ki.5000040.
Reference Type
BACKGROUND
Drachenberg CB, Hirsch HH, Ramos E, Papadimitriou JC. Polyomavirus disease in renal transplantation: review of pathological findings and diagnostic methods. Hum Pathol. 2005 Dec;36(12):1245-55. doi: 10.1016/j.humpath.2005.08.009. Epub 2005 Oct 19.
Reference Type
BACKGROUND
Hirsch HH, Steiger J. Polyomavirus BK. Lancet Infect Dis. 2003 Oct;3(10):611-23. doi: 10.1016/s1473-3099(03)00770-9.
Reference Type
BACKGROUND
Binet I, Nickeleit V, Hirsch HH, Prince O, Dalquen P, Gudat F, Mihatsch MJ, Thiel G. Polyomavirus disease under new immunosuppressive drugs: a cause of renal graft dysfunction and graft loss. Transplantation. 1999 Mar 27;67(6):918-22. doi: 10.1097/00007890-199903270-00022.
Reference Type
BACKGROUND
Ramos E, Drachenberg CB, Papadimitriou JC, Hamze O, Fink JC, Klassen DK, Drachenberg RC, Wiland A, Wali R, Cangro CB, Schweitzer E, Bartlett ST, Weir MR. Clinical course of polyoma virus nephropathy in 67 renal transplant patients. J Am Soc Nephrol. 2002 Aug;13(8):2145-51. doi: 10.1097/01.asn.0000023435.07320.81.
Reference Type
BACKGROUND
Ronco C. Biomarkers for acute kidney injury: is NGAL ready for clinical use? Crit Care. 2014 Dec 10;18(6):680. doi: 10.1186/s13054-014-0680-0.
Reference Type
BACKGROUND
Han SB, Cho B, Kang JH. BK virus-associated hemorrhagic cystitis after pediatric stem cell transplantation. Korean J Pediatr. 2014 Dec;57(12):514-9. doi: 10.3345/kjp.2014.57.12.514. Epub 2014 Dec 31.
Reference Type
BACKGROUND
Nickeleit V, Hirsch HH, Zeiler M, Gudat F, Prince O, Thiel G, Mihatsch MJ. BK-virus nephropathy in renal transplants-tubular necrosis, MHC-class II expression and rejection in a puzzling game. Nephrol Dial Transplant. 2000 Mar;15(3):324-32. doi: 10.1093/ndt/15.3.324.
Reference Type
BACKGROUND
Cekmen MB, Bakirdoven S, Sayan M, Yilmaz A. BK virus nephropathy developing after renal transplantation and its treatment with ciprofloxacin: a case report. Transplant Proc. 2012 Dec;44(10):3044-7. doi: 10.1016/j.transproceed.2012.03.059.
Reference Type
BACKGROUND
Chalasani G, Li Q, Konieczny BT, Smith-Diggs L, Wrobel B, Dai Z, Perkins DL, Baddoura FK, Lakkis FG. The allograft defines the type of rejection (acute versus chronic) in the face of an established effector immune response. J Immunol. 2004 Jun 15;172(12):7813-20. doi: 10.4049/jimmunol.172.12.7813.
Reference Type
BACKGROUND
Zaman RA, Ettenger RB, Cheam H, Malekzadeh MH, Tsai EW. A novel treatment regimen for BK viremia. Transplantation. 2014 Jun 15;97(11):1166-71. doi: 10.1097/01.TP.0000441825.72639.4f.
Reference Type
BACKGROUND
Hoppe-Seyler K, Sauer P, Lohrey C, Hoppe-Seyler F. The inhibitors of nucleotide biosynthesis leflunomide, FK778, and mycophenolic acid activate hepatitis B virus replication in vitro. Hepatology. 2012 Jul;56(1):9-16. doi: 10.1002/hep.25602. Epub 2012 Jun 1.
Reference Type
BACKGROUND
Aldred KJ, Kerns RJ, Osheroff N. Mechanism of quinolone action and resistance. Biochemistry. 2014 Mar 18;53(10):1565-74. doi: 10.1021/bi5000564. Epub 2014 Mar 7.
Reference Type
BACKGROUND
Mateo R, Cho Y, Singh G, Stapfer M, Donovan J, Kahn J, Fong TL, Sher L, Jabbour N, Aswad S, Selby RR, Genyk Y. Risk factors for graft survival after liver transplantation from donation after cardiac death donors: an analysis of OPTN/UNOS data. Am J Transplant. 2006 Apr;6(4):791-6. doi: 10.1111/j.1600-6143.2006.01243.x.
Reference Type
BACKGROUND
Matsuoka L, Shah T, Aswad S, Bunnapradist S, Cho Y, Mendez RG, Mendez R, Selby R. Pulsatile perfusion reduces the incidence of delayed graft function in expanded criteria donor kidney transplantation. Am J Transplant. 2006 Jun;6(6):1473-8. doi: 10.1111/j.1600-6143.2006.01323.x.
Reference Type
BACKGROUND
Johnston TD, Thacker LR, Jeon H, Lucas BA, Ranjan D. Sensitivity of expanded-criteria donor kidneys to cold ischaemia time. Clin Transplant. 2004;18 Suppl 12:28-32. doi: 10.1111/j.1399-0012.2004.00214.x.
Reference Type
BACKGROUND
Israni AK, Salkowski N, Gustafson S, Snyder JJ, Friedewald JJ, Formica RN, Wang X, Shteyn E, Cherikh W, Stewart D, Samana CJ, Chung A, Hart A, Kasiske BL. New national allocation policy for deceased donor kidneys in the United States and possible effect on patient outcomes. J Am Soc Nephrol. 2014 Aug;25(8):1842-8. doi: 10.1681/ASN.2013070784. Epub 2014 May 15.
Reference Type
BACKGROUND
Duan KI, Englesbe MJ, Volk ML. Centers for Disease Control 'high-risk' donors and kidney utilization. Am J Transplant. 2010 Feb;10(2):416-20. doi: 10.1111/j.1600-6143.2009.02931.x. Epub 2009 Dec 2.
Reference Type
BACKGROUND
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
5150278
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.
Induction Related BK Viremia in Renal Transplant Patients
NCT00610961
COMPLETED
Safety and Efficacy Study of Everolimus to Treat BK Virus Infection in Kidney Transplant Recipients
NCT01624948
COMPLETED
PHASE4
An Open-Label, Study to Treat Patients With Renal Allograft and Polyoma BK Viruria
NCT01620268
TERMINATED
PHASE2
The Efficacy of Everolimus With Reduced-dose Tacrolimus Versus Reduced-dose Tacrolimus and Leflunomide in Treatment of BK Virus Infection in Kidney Transplantation Recipient
NCT04542733
RECRUITING
NA
Conversion to Envarsus Post Kidney Transplant Protects Against BK Infection
NCT03762473
COMPLETED
PHASE2
Study of FK778 in Renal Transplant Recipients With Untreated BK Nephropathy
NCT00104338
TERMINATED
PHASE2
An Open Study on the Preventive Effect of Early Mizoribine Conversion on BKV Nephropathy in Renal Transplant Recipients
NCT05293704
UNKNOWN
PHASE4
Study Cyclosporine (CsA) Versus Tacrolimus (Tacro) After Campath Induction in Kidney Transplantation
NCT01346397
COMPLETED
Sirolimus Associated With Tacrolimus at Low Doses in Elderly Kidney Transplant Patients
NCT02683291
COMPLETED
PHASE4
A Clinical Study of Letermovir (MK-8228) in Children and Adolescents Who Receive a Kidney Transplant (KT) (MK-8228-077)
NCT07199465
RECRUITING
PHASE1
Study of Posoleucel (Formerly Known as ALVR105; Viralym-M) in Kidney Transplant Patients With BK Viremia
NCT04605484
COMPLETED
PHASE2
Use of Belatacept to Delay Tacrolimus Initiation in Kidney Transplant Patients with Delayed Graft Function
NCT06091995
ACTIVE_NOT_RECRUITING
Study to Confirm of the Safety and Tolerability of Brincidofovir in Subjects With BK Virus Infection (Viremia) After Kidney Transplantation
NCT05511779
TERMINATED
PHASE2
Switch to Bictegravir/Emtricitabine/Tenofovir Alafenamide (BIC/F/TAF) After Renal Transplant
NCT04530630
COMPLETED
PHASE4
Conversion Study From Cyclosporine to FK506MR Based Immunosuppression in Kidney Transplant Subjects
NCT00481481
COMPLETED
PHASE3
Pre-transplant Assessment of Tacrolimus Blood Level Concentration, as a Predictor of Tacrolimus Dose Requirements After Kidney Transplantation
NCT00297310
COMPLETED
PHASE4
Efficacy and Safety Study of the Switch From Cyclosporin to Tacrolimus in Renal Transplant Recipients
NCT02706678
COMPLETED
PHASE4
Pharmacokinetics of Tacrolimus in Kidney Transplant Recipients: Once Daily Versus Twice Daily Dosing
NCT00028171
COMPLETED
NA
Longitudinal Changes in Donor-Derived Cell-Free DNA With Tocilizumab Treatment for Chronic Antibody-Mediated Rejection
NCT03859388
ACTIVE_NOT_RECRUITING
Safety and Efficacy of Converting Maintenance Kidney and Liver Transplant Recipients With Abnormal Glucose Metabolism From Tacrolimus to Cyclosporine Micro-emulsion
NCT00150085
TERMINATED
PHASE4
Pediatric Kidney Transplant Without Calcineurin Inhibitors
NCT00023231
COMPLETED
NA
A Study to Assess the Safety and Efficacy of a Tacrolimus Based Immunosuppressive Regimen in Stable Kidney Transplant Recipients Converted From Cyclosporine Based Immunosuppressive Regimen
NCT02963103
TERMINATED
PHASE4