Matching Patients With Hematologic Malignancy to Adequate Clinical Trials
NCT ID: NCT02758080
Last Updated: 2017-10-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
90 participants
INTERVENTIONAL
2016-01-31
2019-06-30
Brief Summary
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Detailed Description
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In this pragmatic clinical trial, cancer driving mutations in hematologic malignancy patients is identified using next generation sequencing, and assign patients to an appropriate clinical trial which is anticipated to exhibit the best response. The improvement of outcome of this biomarker-driven assignment is investigated.
Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Matched
A molecular profile is identified using next generation sequencing. A participant in this arm is assigned to early clinical trial studying targeted agent, which is anticipated to have the best response rate.
Matching on the basis of molecular analysis
Not matched
A participants in this arm is assigned to a clinical trial at physician's choice.
Matching on the basis of physician's choice
Interventions
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Matching on the basis of molecular analysis
Matching on the basis of physician's choice
Eligibility Criteria
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Inclusion Criteria
* incurable hematologic malignancy patients who failed to respond to standard treatment
* patients who agreed to this protocol with informed consent
* Eastern Cooperative Oncology Group performance status ≤ 3
* Tolerable major organ function determined by laboratory examination
Exclusion Criteria
* patients with poor compliance
* patients who can not give an informed consent
* patients who are participating another clinical trials
18 Years
ALL
No
Sponsors
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The Korea Health Technology R&D Project through the Korea Health Industry Development Institute
UNKNOWN
Ministry of Health, Republic of Korea
OTHER_GOV
Seoul National University Hospital
OTHER
Responsible Party
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Youngil Koh
Assistant professor
Principal Investigators
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Youngil Koh, MD
Role: PRINCIPAL_INVESTIGATOR
Seoul National University Hospital
Locations
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Seoul National University Hospital
Seoul, , South Korea
Countries
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Central Contacts
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Facility Contacts
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Ryul Kim, MD
Role: primary
References
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Other Identifiers
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2015-1690
Identifier Type: -
Identifier Source: org_study_id