Study of A Special Vessel Subtype in Bone Samples From Patients With Osteoporotic and Nonosteoporotic Fracture
NCT ID: NCT02750046
Last Updated: 2016-04-25
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
30 participants
INTERVENTIONAL
2016-03-31
2018-02-28
Brief Summary
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PURPOSE: This research study is looking at changes of a special vessel subtype in bone samples from patients with osteoporotic and nonosteoporotic fracture.
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Detailed Description
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1. Establish type H vessel in bone specimen in patients with hip fracture.
2. Explore the correlation of BMD and type H vessel.
OUTLINE:
1. Collect human bone specimens from patients with Osteoporotic and Nonosteoporotic Fracture.
2. Provide a repository for storage of tissue and make these specimens available for approved projects by laboratory-based investigators.
3. Observe the type H vessel in bone slice by immunofluorescence staining.
4. Collect clinical data on these patients including bone mineral density.
5. Investigate the relationship between BMD and type H vessel.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
DIAGNOSTIC
SINGLE
Study Groups
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osteoporotic fractures
patients with osteoporotic fractures, including femoral neck fracture and pertrochanteric fracture. Total hip arthroplasty or proximal femoral nails was needed.
total hip arthroplasty or proximal femoral nails
Bone samples from Hip fracture were collected when total hip arthroplasty or proximal femoral nails was performed.
nonosteoporotic fractures
patients with nonosteoporotic fractures, including femoral neck fracture and pertrochanteric fracture. Total hip arthroplasty or proximal femoral nails was needed.
total hip arthroplasty or proximal femoral nails
Bone samples from Hip fracture were collected when total hip arthroplasty or proximal femoral nails was performed.
Interventions
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total hip arthroplasty or proximal femoral nails
Bone samples from Hip fracture were collected when total hip arthroplasty or proximal femoral nails was performed.
Eligibility Criteria
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Inclusion Criteria
2. Genders Eligible for Study: Woman
3. Accepts Healthy Volunteers: NO
4. Study Population: Female patients with hip fracture. -
Exclusion Criteria
2. Known chronic or systemic diseases
3. Hormone therapy in the previous 3 months
4. Bone metabolism and drug therapy
60 Years
75 Years
FEMALE
No
Sponsors
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Second Affiliated Hospital of Soochow University
OTHER
Responsible Party
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Principal Investigators
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Youjia Xu, PhD. M.D.
Role: STUDY_CHAIR
Second Affiliated Hospital of Soochow University
Locations
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Second Affiliated Hospital of Soochow University
Suzhou, Jiangsu, China
Countries
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References
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Kusumbe AP, Ramasamy SK, Adams RH. Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone. Nature. 2014 Mar 20;507(7492):323-328. doi: 10.1038/nature13145. Epub 2014 Mar 12.
Xie H, Cui Z, Wang L, Xia Z, Hu Y, Xian L, Li C, Xie L, Crane J, Wan M, Zhen G, Bian Q, Yu B, Chang W, Qiu T, Pickarski M, Duong LT, Windle JJ, Luo X, Liao E, Cao X. PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis. Nat Med. 2014 Nov;20(11):1270-8. doi: 10.1038/nm.3668. Epub 2014 Oct 5.
Ramasamy SK, Kusumbe AP, Wang L, Adams RH. Endothelial Notch activity promotes angiogenesis and osteogenesis in bone. Nature. 2014 Mar 20;507(7492):376-380. doi: 10.1038/nature13146. Epub 2014 Mar 12.
Kusumbe AP, Adams RH. Osteoclast progenitors promote bone vascularization and osteogenesis. Nat Med. 2014 Nov;20(11):1238-40. doi: 10.1038/nm.3747. No abstract available.
Wang L, Zhou F, Zhang P, Wang H, Qu Z, Jia P, Yao Z, Shen G, Li G, Zhao G, Li J, Mao Y, Xie Z, Xu W, Xu Y, Xu Y. Human type H vessels are a sensitive biomarker of bone mass. Cell Death Dis. 2017 May 4;8(5):e2760. doi: 10.1038/cddis.2017.36.
Other Identifiers
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SencondSoochowU
Identifier Type: -
Identifier Source: org_study_id
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