Collagen Alterations in Patients With Abdominal Wall Hernias

NCT ID: NCT02734563

Last Updated: 2017-07-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

174 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-01-31

Study Completion Date

2014-12-31

Brief Summary

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The aim of this study was to evaluate collagen turnover in patients with multiple hernias

Detailed Description

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Venous blood was collected and markers for type IV and V collagen synthesis and breakdown was measured

Conditions

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Hernia, Abdominal

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Multiple hernia group

Males undergoing at least three repairs of abdominal wall hernias at three different anatomic locations. Collagen turnover is analysed.

Collagen turnover

Intervention Type OTHER

Type IV and V collagen synthesis and breakdown

Control group

Males without any history or presence of hernias

Collagen turnover

Intervention Type OTHER

Type IV and V collagen synthesis and breakdown

Interventions

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Collagen turnover

Type IV and V collagen synthesis and breakdown

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* patients with a history of three hernia repairs (multiple hernia group)
* patients without any history or presence of hernias (control group)

Exclusion Criteria

* connective tissue disorder (Ehlers-Danloss/Marfan)
* presence of hernia upon clinical examination (control group)
Minimum Eligible Age

18 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Bispebjerg Hospital

OTHER

Sponsor Role lead

Responsible Party

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Lars Nannestad Jorgensen

Professor, MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Lars N Jorgensen, MD

Role: PRINCIPAL_INVESTIGATOR

Bispebjerg Hospital, Dept. of Surgery

Locations

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Bispebjerg Hospital

Copenhagen, NV, Denmark

Site Status

Countries

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Denmark

Other Identifiers

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H.A-2009-045

Identifier Type: -

Identifier Source: org_study_id

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