Betafoam Diabetes Mellitus Foot Study

NCT ID: NCT02732886

Last Updated: 2017-11-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

71 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-03-29

Study Completion Date

2017-09-29

Brief Summary

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This study is to compare the efficacy and safety of Medifoam® and Betafoam®, which is a new dressing that contains povidone-iodine, in patients with diabetes foot ulcer. 70 patients (35 each arm) are targeted to be enrolled in this study. Treatment follow periods are 8weeks.

Detailed Description

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Conditions

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Diabetes Mellitus Foot Ulcer

Keywords

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foam dressing

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Betafoam®

Brand name: Betafoam® Generic term: Wound dressing with 3% povidone iodine

Group Type EXPERIMENTAL

Betafoam®

Intervention Type DEVICE

Foam dressing including Betadine iodine

Medifoam®

Brand name: Medifoam® Generic term: Wound dressing

Group Type ACTIVE_COMPARATOR

Medifoam®

Intervention Type DEVICE

Foam Dressing

Interventions

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Medifoam®

Foam Dressing

Intervention Type DEVICE

Betafoam®

Foam dressing including Betadine iodine

Intervention Type DEVICE

Other Intervention Names

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Medifoam Betafoam

Eligibility Criteria

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Inclusion Criteria

* Adult of age ≥19 years at the time of informed consent
* Foot ulcers related to diabetes mellitus:

* Present
* Type I or II diabetes mellitus with HbA1c \<10%, or serum creatinine ≤ 200 μmol/l
* Wagner grade I-II (Partial- or full- thickness and not involving bone, tendon, or capsule (probing to tendon or capsule)
* Post -debridement ulcer bed size ≥ 1\*1cm2
* No clinical signs of infection \& necrosis
* Site at anywhere below ankle
* No vascular abnormalities of the foot by palpation (i.e. the dorsalis pedis should be examined by the physician and characterized as present or absent)

Exclusion Criteria

* Pregnant \& lactating females
* Known allergy to the dressing product including povidone iodine
* Known hyperthyroidism or other acute thyroid diseases
* Subject with clinical infection who should be administered antibiotics continuously after enrolment
* Subject has any condition(s) that seriously compromises the patient's ability to complete this study.
* Subject has participated in interventional study utilizing an investigational drug within the previous 30 days
* Subjects with known immune-suppressed state; who undergo chemotherapy or with end-stage renal disease requiring haemodialysis or had kidney transplant surgery previously and with immunosuppressant specifically
* Subjects requiring skin grafting per physician's discretion
* Vulnerable subjects as defined by Good Clinical Practice guidelines.
Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Mundipharma Korea Ltd

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Hyongjin Jung, Dr. PhD.

Role: PRINCIPAL_INVESTIGATOR

Inje University Sangye Paik Hospital,

Locations

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Inje University Sanggye Paik Hospital

Seoul, , South Korea

Site Status

Countries

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South Korea

References

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Gwak HC, Han SH, Lee J, Park S, Sung KS, Kim HJ, Chun D, Lee K, Ahn JH, Kwak K, Chung HJ. Efficacy of a povidone-iodine foam dressing (Betafoam) on diabetic foot ulcer. Int Wound J. 2020 Feb;17(1):91-99. doi: 10.1111/iwj.13236. Epub 2019 Nov 26.

Reference Type DERIVED
PMID: 31773882 (View on PubMed)

Other Identifiers

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BTF15-KR-402

Identifier Type: -

Identifier Source: org_study_id