D-chiro-Inositol in Overweight Type 1 Diabetes Patients

NCT ID: NCT02730949

Last Updated: 2016-04-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

26 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-03-31

Study Completion Date

2015-12-31

Brief Summary

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The purpose of this pilot study was to evaluate the effect of D-chiro-Inositol (DCI) oral supplementation in addiction to folic acid compared to folic acid alone on glycaemic control as assessed by HbA1c in overweight or obese T1D patients undergoing intensive insulin therapy.

A 24 weeks, prospective, randomized control trial was carried out in T1D patients, aged 17-50 years (13 males, 13 females), with disease duration \> 1 year and BMI \>25, attending as outpatients the Endocrinology and Diabetes Unit of University Campus Bio-Medico in Rome

Detailed Description

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Conditions

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Type 1 Diabetes

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1 g D-chiro-Inositol + 400 mcg Folic Acid

1 g D-chiro-Inositol + 400 mcg folic acid once daily

Group Type EXPERIMENTAL

D-chiro-inositol

Intervention Type DIETARY_SUPPLEMENT

Treated group

Folic Acid

Intervention Type DIETARY_SUPPLEMENT

Control group

400 mcg folic

400 mcg folic acid only once daily

Group Type ACTIVE_COMPARATOR

Folic Acid

Intervention Type DIETARY_SUPPLEMENT

Control group

Interventions

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D-chiro-inositol

Treated group

Intervention Type DIETARY_SUPPLEMENT

Folic Acid

Control group

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* T1D patients
* aged 17-50 years
* disease duration \> 1 year
* BMI \>25

Exclusion Criteria

* learning disabilities
* presence of chronic conditions potentially able to influence daily activities (visual or auditory disability, motor impairment for neurological or orthopaedic problems).
* T1D patients affected from diabetic complications
* pregnancy
Minimum Eligible Age

17 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Campus Bio-Medico University

OTHER

Sponsor Role lead

Responsible Party

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Professor Paolo Pozzilli

Prof

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Paolo Pozzilli, MD

Role: PRINCIPAL_INVESTIGATOR

University Campus Bio-medico

Locations

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University Campus Bio Medico

Rome, , Italy

Site Status

Countries

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Italy

References

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Maurizi AR, Menduni M, Del Toro R, Kyanvash S, Maggi D, Guglielmi C, Pantano AL, Defeudis G, Fioriti E, Manfrini S, Pozzilli P. A pilot study of D-chiro-inositol plus folic acid in overweight patients with type 1 diabetes. Acta Diabetol. 2017 Apr;54(4):361-365. doi: 10.1007/s00592-016-0954-x. Epub 2016 Dec 30.

Reference Type DERIVED
PMID: 28039583 (View on PubMed)

Other Identifiers

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16/14PARComETCBM

Identifier Type: -

Identifier Source: org_study_id

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