Measuring Cortisol Levels in Persons With Parkinson's (PD)
NCT ID: NCT02727270
Last Updated: 2023-12-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
131 participants
OBSERVATIONAL
2016-06-30
2023-11-16
Brief Summary
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Detailed Description
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Participants will collect saliva at twelve time points - four times a day for three days.
Visits will be conducted virtually (over the internet).
The virtual visit is to assess Parkinson's or Huntington's disease status, stress, mood, and quality of life.
Conditions
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Keywords
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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Parkinson's - High Stress *FULL NOT RECRUITING
Parkinson's disease patients with self-reported high strain/stress.
No Intervention - Observational Study
No Intervention - Observational Study
Parkinson's - Low Stress *FULL NOT RECRUITING
Parkinson's disease patients with self-reported low strain/stress.
No Intervention - Observational Study
No Intervention - Observational Study
Controls - High Stress *FULL NOT RECRUITING
Healthy controls (no neurological disease) with self-reported high strain/stress.
No Intervention - Observational Study
No Intervention - Observational Study
Controls - Low Stress *FULL NOT RECRUITING
Healthy controls (no neurological disease) with self-reported low strain/stress.
No Intervention - Observational Study
No Intervention - Observational Study
Huntington's - High Stress *FULL NOT RECRUITING
Huntington's disease patients and/or Huntington's disease gene carriers with self-reported high strain/stress.
No Intervention - Observational Study
No Intervention - Observational Study
Huntington's - Low Stress *FULL NOT RECRUITING
Huntington's disease patients and/or Huntington's disease gene carriers with self-reported low strain/stress.
No Intervention - Observational Study
No Intervention - Observational Study
Parkinson's Disease - ReEnrollment (COVID-19) *FULL NOT RECRUITING
Parkinson's disease patients that had previously completed the study.
No Intervention - Observational Study
No Intervention - Observational Study
Interventions
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No Intervention - Observational Study
No Intervention - Observational Study
Eligibility Criteria
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Inclusion Criteria
* No significant neurological disorder
* PSS score of greater than or equal to 13.
Group (5) Inclusion:
* HD diagnosis or HD gene carrier
* a Perceived Stress Scale (PSS) score higher than or equal to 13.
Group (6) Inclusion:
* HD diagnosis or HD gene carrier
* PSS score lower than 13
Group (7) Inclusion:
* PD diagnosis
* Prior completion of the study.
Exclusion Criteria
18 Years
99 Years
ALL
Yes
Sponsors
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Portland VA Medical Center
FED
Oregon Clinical and Translational Research Institute
OTHER
Huntington's Disease Society of America
OTHER
Oregon Health and Science University
OTHER
Responsible Party
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Amie Hiller, MD
Neurologist
Principal Investigators
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Amie L Hiller, MD
Role: PRINCIPAL_INVESTIGATOR
Oregon Health and Science University
Locations
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Oregon Health & Science Universtiy
Portland, Oregon, United States
VA Portland Health Care System
Portland, Oregon, United States
Countries
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References
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Ceravolo R, Frosini D, Poletti M, Kiferle L, Pagni C, Mazzucchi S, Volterrani D, Bonuccelli U. Mild affective symptoms in de novo Parkinson's disease patients: relationship with dopaminergic dysfunction. Eur J Neurol. 2013 Mar;20(3):480-485. doi: 10.1111/j.1468-1331.2012.03878.x. Epub 2012 Oct 18.
Hartmann A, Veldhuis JD, Deuschle M, Standhardt H, Heuser I. Twenty-four hour cortisol release profiles in patients with Alzheimer's and Parkinson's disease compared to normal controls: ultradian secretory pulsatility and diurnal variation. Neurobiol Aging. 1997 May-Jun;18(3):285-9. doi: 10.1016/s0197-4580(97)80309-0.
Marsden CD, Owen DA. Mechanisms underlying emotional variation in parkinsonian tremor. Neurology. 1967 Jul;17(7):711-5. doi: 10.1212/wnl.17.7.711. No abstract available.
Matousek RH, Dobkin PL, Pruessner J. Cortisol as a marker for improvement in mindfulness-based stress reduction. Complement Ther Clin Pract. 2010 Feb;16(1):13-9. doi: 10.1016/j.ctcp.2009.06.004. Epub 2009 Jul 4.
Other Identifiers
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3794
Identifier Type: OTHER
Identifier Source: secondary_id
5338
Identifier Type: OTHER
Identifier Source: secondary_id
4546
Identifier Type: OTHER
Identifier Source: secondary_id
7186
Identifier Type: OTHER
Identifier Source: secondary_id
15183
Identifier Type: -
Identifier Source: org_study_id