The Effects of Ambient Temperature and Forced-air Warming on Intraoperative Core Temperature
NCT ID: NCT02715076
Last Updated: 2021-05-11
Study Results
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View full resultsBasic Information
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COMPLETED
NA
292 participants
INTERVENTIONAL
2016-01-31
2016-12-31
Brief Summary
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1. the effect of ambient temperature on the rate of core temperature change from 1 to 3 hours after induction of anesthesia (linear phase of the hypothermia curve) in major operations lasting at least a couple of hours and
2. whether the relationship between ambient temperature and rate of core temperature change is different for patients who are or are not warmed with forced-air.
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Detailed Description
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Patients assigned to passive insulation will be covered as usual with a cotton gown and single layer of cloth surgical draping. Patients assigned to forced-air warming will also be covered with a gown and surgical drapes, but a forced-air cover (Bair hugger 63500, 3M) will be inserted between the gown and the skin surface. A lower-body cover (about 91 by 221 cm) will be positioned so the lower end of the forced-air segments extend from the ankles upward for the entire length of the cover in thoracic and abdominal cases. The cover's foot drape will extend over the feet, and in turn be covered by the surgical drape. An upper-body forced-air cover will similarly be applied for patients having hip arthroplasties. The forced-air cover will be connected to a Bair Hugger blower and #635 covers set to "high" (≈43°C).
Ambient temperature will be adjusted to the designated temperature about an hour before a patient enters the operating room and adjusted as necessary to maintain the designated temperature throughout surgery. General anesthesia will be induced as per usual clinical routine. Neuraxial (epidural or spinal) and other regional blocks are permitted.
Any patients whose core temperature decreases to less than 34.5°C will be actively warmed with forced air and the ambient temperature increases to the extent practical.
Conditions
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Study Design
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RANDOMIZED
FACTORIAL
SUPPORTIVE_CARE
NONE
Study Groups
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Ambient Temp 19°C & Passive Insulation
Ambient Temperature 19°C and Passive Insulation: patients assigned to passive insulation will be covered as usual with a cotton gown and single layer of cloth surgical draping.
Ambient Temperature 19°C
Ambient Temperature 19°C
Passive insulation
Patients assigned to passive insulation will be covered as usual with a cotton gown and single layer of cloth surgical draping.
Ambient Temp 19°C & Forced-air Warming
Ambient Temperature 19°C and Forced-air Warming: patients assigned to forced-air warming will also be covered with a gown and surgical drapes, but a forced-air cover (Bair hugger 63500, 3M) will be inserted between the gown and the skin surface.
Ambient Temperature 19°C
Ambient Temperature 19°C
Forced-air cover (Bair hugger 63500, 3M)
Patients assigned to forced-air warming will also be covered with a gown and surgical drapes, but a forced-air cover (Bair hugger 63500, 3M) will be inserted between the gown and the skin surface.
Ambient Temp 21°C & Passive Insulation
Ambient Temperature 21°C and Passive Insulation: patients assigned to passive insulation will be covered as usual with a cotton gown and single layer of cloth surgical draping.
Ambient Temperature 21°C
Ambient Temperature 21°C
Passive insulation
Patients assigned to passive insulation will be covered as usual with a cotton gown and single layer of cloth surgical draping.
Ambient Temp 21°C & Forced-air Warming
Ambient Temperature 21°C and Forced-air Warming: patients assigned to forced-air warming will also be covered with a gown and surgical drapes, but a forced-air cover (Bair hugger 63500, 3M) will be inserted between the gown and the skin surface.
Ambient Temperature 21°C
Ambient Temperature 21°C
Forced-air cover (Bair hugger 63500, 3M)
Patients assigned to forced-air warming will also be covered with a gown and surgical drapes, but a forced-air cover (Bair hugger 63500, 3M) will be inserted between the gown and the skin surface.
Ambient Temp 23°C & Passive Insulation
Ambient Temperature 23°C and Passive Insulation: patients assigned to passive insulation will be covered as usual with a cotton gown and single layer of cloth surgical draping.
Ambient Temperature 23°C
Ambient Temperature 23°C
Passive insulation
Patients assigned to passive insulation will be covered as usual with a cotton gown and single layer of cloth surgical draping.
Ambient Temp 23°C & Forced-air Warming
Ambient Temperature 23°C and Forced-air Warming: patients assigned to forced-air warming will also be covered with a gown and surgical drapes, but a forced-air cover (Bair hugger 63500, 3M) will be inserted between the gown and the skin surface.
Ambient Temperature 23°C
Ambient Temperature 23°C
Forced-air cover (Bair hugger 63500, 3M)
Patients assigned to forced-air warming will also be covered with a gown and surgical drapes, but a forced-air cover (Bair hugger 63500, 3M) will be inserted between the gown and the skin surface.
Interventions
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Ambient Temperature 19°C
Ambient Temperature 19°C
Ambient Temperature 21°C
Ambient Temperature 21°C
Ambient Temperature 23°C
Ambient Temperature 23°C
Forced-air cover (Bair hugger 63500, 3M)
Patients assigned to forced-air warming will also be covered with a gown and surgical drapes, but a forced-air cover (Bair hugger 63500, 3M) will be inserted between the gown and the skin surface.
Passive insulation
Patients assigned to passive insulation will be covered as usual with a cotton gown and single layer of cloth surgical draping.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Patients who would otherwise have been actively warmed
18 Years
80 Years
ALL
No
Sponsors
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The Cleveland Clinic
OTHER
Peking Union Medical College Hospital
OTHER
Responsible Party
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Lijian Pei
Associate Professor
Principal Investigators
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LiJian Pei, MD
Role: PRINCIPAL_INVESTIGATOR
Associate Prof. of Dept. of Anesthesiology, PUMCH
Yuguang Huang, MD
Role: STUDY_CHAIR
Chair of Dept. of Anesthesiology, PUMCH
Daniel I Sessler, MD
Role: STUDY_DIRECTOR
Chair of Dept. of Outcomes Research, Anesthesiology Institute, Cleveland Clinic
Locations
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Dept. of Anesthesiology, PUMCH
Beijing, , China
Countries
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References
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Hynson JM, Sessler DI. Intraoperative warming therapies: a comparison of three devices. J Clin Anesth. 1992 May-Jun;4(3):194-9. doi: 10.1016/0952-8180(92)90064-8.
Rajagopalan S, Mascha E, Na J, Sessler DI. The effects of mild perioperative hypothermia on blood loss and transfusion requirement. Anesthesiology. 2008 Jan;108(1):71-7. doi: 10.1097/01.anes.0000296719.73450.52.
Kurz A, Sessler DI, Lenhardt R. Perioperative normothermia to reduce the incidence of surgical-wound infection and shorten hospitalization. Study of Wound Infection and Temperature Group. N Engl J Med. 1996 May 9;334(19):1209-15. doi: 10.1056/NEJM199605093341901.
Lenhardt R, Marker E, Goll V, Tschernich H, Kurz A, Sessler DI, Narzt E, Lackner F. Mild intraoperative hypothermia prolongs postanesthetic recovery. Anesthesiology. 1997 Dec;87(6):1318-23. doi: 10.1097/00000542-199712000-00009.
Kurz A, Sessler DI, Narzt E, Bekar A, Lenhardt R, Huemer G, Lackner F. Postoperative hemodynamic and thermoregulatory consequences of intraoperative core hypothermia. J Clin Anesth. 1995 Aug;7(5):359-66. doi: 10.1016/0952-8180(95)00028-g.
Matsukawa T, Sessler DI, Christensen R, Ozaki M, Schroeder M. Heat flow and distribution during epidural anesthesia. Anesthesiology. 1995 Nov;83(5):961-7. doi: 10.1097/00000542-199511000-00008.
Matsukawa T, Sessler DI, Sessler AM, Schroeder M, Ozaki M, Kurz A, Cheng C. Heat flow and distribution during induction of general anesthesia. Anesthesiology. 1995 Mar;82(3):662-73. doi: 10.1097/00000542-199503000-00008.
Hynson JM, Sessler DI, Moayeri A, McGuire J, Schroeder M. The effects of preinduction warming on temperature and blood pressure during propofol/nitrous oxide anesthesia. Anesthesiology. 1993 Aug;79(2):219-28, discussion 21A-22A. doi: 10.1097/00000542-199308000-00005.
Camus Y, Delva E, Sessler DI, Lienhart A. Pre-induction skin-surface warming minimizes intraoperative core hypothermia. J Clin Anesth. 1995 Aug;7(5):384-8. doi: 10.1016/0952-8180(95)00051-i.
Kurz A, Sessler DI, Christensen R, Dechert M. Heat balance and distribution during the core-temperature plateau in anesthetized humans. Anesthesiology. 1995 Sep;83(3):491-9. doi: 10.1097/00000542-199509000-00007.
Roe CF. Effect of bowel exposure on body temperature during surgical operations. Am J Surg. 1971 Jul;122(1):13-5. doi: 10.1016/0002-9610(71)90338-2. No abstract available.
Rajek A, Greif R, Sessler DI, Baumgardner J, Laciny S, Bastanmehr H. Core cooling by central venous infusion of ice-cold (4 degrees C and 20 degrees C) fluid: isolation of core and peripheral thermal compartments. Anesthesiology. 2000 Sep;93(3):629-37. doi: 10.1097/00000542-200009000-00010.
Sessler DI, McGuire J, Moayeri A, Hynson J. Isoflurane-induced vasodilation minimally increases cutaneous heat loss. Anesthesiology. 1991 Feb;74(2):226-32. doi: 10.1097/00000542-199102000-00006.
Sessler DI, McGuire J, Sessler AM. Perioperative thermal insulation. Anesthesiology. 1991 May;74(5):875-9. doi: 10.1097/00000542-199105000-00012.
Sessler DI, Moayeri A. Skin-surface warming: heat flux and central temperature. Anesthesiology. 1990 Aug;73(2):218-24.
Giesbrecht GG, Ducharme MB, McGuire JP. Comparison of forced-air patient warming systems for perioperative use. Anesthesiology. 1994 Mar;80(3):671-9. doi: 10.1097/00000542-199403000-00026.
Morris RH. Influence of ambient temperature on patient temperature during intraabdominal surgery. Ann Surg. 1971 Feb;173(2):230-3. doi: 10.1097/00000658-197102000-00008. No abstract available.
Morris RH. Operating room temperature and the anesthetized, paralyzed patient. Arch Surg. 1971 Feb;102(2):95-7. doi: 10.1001/archsurg.1971.01350020005002. No abstract available.
Morris RH, Wilkey BR. The effects of ambient temperature on patient temperature during surgery not involving body cavities. Anesthesiology. 1970 Feb;32(2):102-7. doi: 10.1097/00000542-197002000-00003. No abstract available.
Wang CS, Chen CL, Huang CJ, Cheng KW, Chen KH, Wang CC, Concejero AM, Cheng YF, Huang TL, Wang SH, Lin CC, Liu YW, Yong CC, Yang CH, Jawan B. Effects of different operating room temperatures on the body temperature undergoing live liver donor hepatectomy. Transplant Proc. 2008 Oct;40(8):2463-5. doi: 10.1016/j.transproceed.2008.07.077.
Tander B, Baris S, Karakaya D, Ariturk E, Rizalar R, Bernay F. Risk factors influencing inadvertent hypothermia in infants and neonates during anesthesia. Paediatr Anaesth. 2005 Jul;15(7):574-9. doi: 10.1111/j.1460-9592.2005.01504.x.
Ozer AB, Tosun F, Demirel I, Unlu S, Bayar MK, Erhan OL. The effects of anesthetic technique and ambient temperature on thermoregulation in lower extremity surgery. J Anesth. 2013 Aug;27(4):528-34. doi: 10.1007/s00540-013-1555-2. Epub 2013 Jan 23.
Cheng KW, Wang CH, Chen CL, Jawan B, Wang CC, Concejero AM, Wang SH, Liu YW, Yong CC, Yang CH, Huang CJ. Decreased fresh gas flow cannot compensate for an increased operating room temperature in maintaining body temperature during donor hepatectomy for living liver donor hepatectomy. Transplant Proc. 2010 Apr;42(3):703-4. doi: 10.1016/j.transproceed.2010.02.065.
Frank SM, Beattie C, Christopherson R, Norris EJ, Rock P, Parker S, Kimball AW Jr. Epidural versus general anesthesia, ambient operating room temperature, and patient age as predictors of inadvertent hypothermia. Anesthesiology. 1992 Aug;77(2):252-7. doi: 10.1097/00000542-199208000-00005.
Sun C, Gao H, Zhang Y, Pei L, Huang Y. Risk Stratification for Organ/Space Surgical Site Infection in Advanced Digestive System Cancer. Front Oncol. 2021 Nov 9;11:705335. doi: 10.3389/fonc.2021.705335. eCollection 2021.
Other Identifiers
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ZS-878
Identifier Type: -
Identifier Source: org_study_id
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