Tolerability and Pharmacokinetic Study of Econazole Nitrate and Benzydamine HCl Intravaginal Cream

NCT ID: NCT02713893

Last Updated: 2018-01-17

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 48 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2015-09-30
• Study Completion Date: 2016-06-15

Brief Summary

The primary objective of the study is to evaluate local tolerability of the new Econazole/Benzydamine product, in comparison with the Econazole and Benzydamine stand-alone products and placebo. Pharmacokinetics of the study products after single and repeated applications once a day for 15 days, safety of the investigational products and comfort of use will also be evaluated as secondary objectives.

Conditions

Healthy

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: OTHER
• Blinding Strategy: TRIPLE

Study Groups

Econazole nitrate 1% plus Benzydamine HCl 0.12%

5 grams of Econazole nitrate 1% plus Benzydamine HCl 0.12% intravaginal cream, once daily for 15 consecutive days

Group Type: EXPERIMENTAL

Econazole nitrate 1% plus Benzydamine HCl 0.12% intravaginal cream

Intervention Type: DRUG

Placebo plus Econazole nitrate 1%

5 grams of Placebo plus Econazole nitrate 1% intravaginal cream, once daily for 15 consecutive days

Group Type: ACTIVE_COMPARATOR

Placebo plus Econazole nitrate 1% intravaginal cream

Intervention Type: DRUG

Placebo plus Benzydamine HCl 0.12%

5 grams of Placebo plus Benzydamine HCl 0.12% intravaginal cream, once daily for 15 consecutive days.

Group Type: ACTIVE_COMPARATOR

Placebo plus Benzydamine HCl 0.12% intravaginal cream

Intervention Type: DRUG

Placebo

5 grams of Placebo intravaginal cream, once daily for 15 consecutive days.

Group Type: PLACEBO_COMPARATOR

Placebo intravaginal cream

Intervention Type: DRUG

Interventions

Econazole nitrate 1% plus Benzydamine HCl 0.12% intravaginal cream

Intervention Type: DRUG

Placebo plus Econazole nitrate 1% intravaginal cream

Intervention Type: DRUG

Placebo plus Benzydamine HCl 0.12% intravaginal cream

Intervention Type: DRUG

Placebo intravaginal cream

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. Informed consent: signed written informed consent before inclusion in the study;

2. Sex and age: females, aged 18-55 years old inclusive;

3. Body Mass Index (BMI): 18.5-30 kg/m2 inclusive;

4. Vital signs: systolic blood pressure 100-139 mmHg, diastolic blood pressure 50-89 mmHg, heart rate 50-90 bpm, measured after 5 min at rest (sitting position);

5. Full comprehension: ability to comprehend the full nature and purpose of the study, including possible risks and side effects; ability to co-operate with the investigator and to comply with the requirements of the entire study;

6. Sexual abstinence: agreement to sexual abstinence during the study;

1. hormonal oral, implantable, transdermal, or injectable contraceptives for at least 2 months before the screening visit;

2. a non-hormonal intrauterine device [IUD] for at least 2 months before the screening visit;

3. a male sexual partner who agrees to use a male condom;

4. a vasectomised sexual partner. Female participants of non-child-bearing potential will be admitted. For all female subjects, pregnancy test result must be negative at screening and at each scheduled evaluation;

8. PAP test: negative result at PAP test (i.e. normal PAP test result without atypical cells) at screening.

Exclusion Criteria

1. ECG (12-leads, supine position): clinically significant abnormalities;

2. Physical findings: clinically significant abnormal physical findings which could interfere with the objectives of the study as judged by the investigator;

3. Laboratory analyses: clinically significant abnormal laboratory values indicative of physical illness;

4. Allergy: ascertained or presumptive hypersensitivity (including allergies) to the active ingredients (econazole and/ or benzydamine) and/or formulations' excipients or related drugs, e.g. other azoles; history of anaphylaxis to drugs or allergic reactions in general, which the investigator considers may affect the outcome of the study;

5. Diseases: relevant history of renal, hepatic, gastrointestinal, genitourinary, cardiovascular, respiratory, skin, haematological, endocrine or neurological diseases that may interfere with the aim of the study or affect the subject's safety;

6. Genitourinary disease: presence of any specific genitourinary symptoms detected at Visit 2 with the relevant questionnaire (genitourinary symptoms questionnaire);

7. Infection history: history of bacterial urinary tract or bacterial and fungal vaginal infections for 3 weeks before the screening visit;

8. Infections: bacterial or fungal infections (microbiology assessment);

9. Gynaecological findings: clinically significant abnormal findings at the gynaecological visit performed by the study gynaecologist;

10. Mucosa conditions: altered mucosa conditions affecting the site of application (e.g. open lesion or other);

11. Vaginal conditions: use of vaginal detergents, soaps and washes that, in the investigator's opinion, may have an influence on vaginal pH and/or change the vaginal flora;

12. Medications: any medication (topical or systemic), including over the counter, herbal medication, topical drugs on the application area and anticoagulants, such as warfarin and acenocoumarol, for 2 weeks before the start of the study. Hormonal contraceptives and hormonal replacement therapies are allowed. Paracetamol will be allowed as a counter-measure for adverse events, on a case by case basis, if deemed appropriate by the investigator;

13. Investigative drug studies: participation in the evaluation of any drug for 3 months before this study, calculated from the first day of the month following the last visit of a previous study and the first day of the present study (date of the informed consent signature);

14. Blood donation: blood donations for 3 months before this study;

15. Drug, alcohol, caffeine, tobacco: history of drug, alcohol (> 1 drink/day, defined according to USDA Dietary Guidelines 2010), tobacco (≥ 10 cigarettes/day) or caffeine (> 5 cups coffee/tea/day) abuse;

16. Diet: Abnormal diets (< 1600 or > 3500 kcal/day) or substantial changes in eating habits in the 4 weeks before this study; vegetarians

17. Pregnancy: positive or missing pregnancy test at screening or day 1, pregnant or lactating women or females of child-bearing potential not following adequate contraceptive procedures;

18. Non-compliance: subjects suspected to have a high potential for non-compliance to the study procedures according to the investigator's judgement, including non-compliance to sexual abstinence during the study;

19. Drug test (cocaine, amphetamine, methamphetamine, cannabinoids, opiates and ecstasy): positive result at the drug test at screening

20. Alcohol test: positive alcohol breath test at day 1

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 55 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: Yes

Sponsors

Cross Research S.A.

INDUSTRY

Sponsor Role: collaborator

Aziende Chimiche Riunite Angelini Francesco S.p.A

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Milko Radicioni, MD

Role: PRINCIPAL_INVESTIGATOR

Cross Research S.A.

Locations

CROSS Research S.A., Phase I Unit

Arzo, , Switzerland

Countries

Switzerland

Other Identifiers

CRO-PK-14-289

Identifier Type: OTHER

Identifier Source: secondary_id

030(4A)HO14387

Identifier Type: -

Identifier Source: org_study_id