Pharmacokinetic-Pharmacodynamic Relationship of Metformin in Healthy Volunteers
NCT ID: NCT02712619
Last Updated: 2016-03-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE1
20 participants
INTERVENTIONAL
2014-05-31
Brief Summary
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* low dose group (375/250 mg)
* high dose group (1000/1000mg)
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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metformin 250mg
metformin 375/250 mg
Metformin
metformin 1000mg
metformin 1000/1000 mg
Metformin
Interventions
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Metformin
Eligibility Criteria
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Inclusion Criteria
* Body weight 50 to 100 kg
* fasting serum glucose 70 to 125 mg/dL
* who provide informed consent voluntarily
Exclusion Criteria
* any co/prior medication within 14 days of study drug administration
20 Years
45 Years
MALE
Yes
Sponsors
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Seoul National University Hospital
OTHER
Responsible Party
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Jae Yong Chung
MD, PhD
References
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Chung H, Oh J, Yoon SH, Yu KS, Cho JY, Chung JY. A non-linear pharmacokinetic-pharmacodynamic relationship of metformin in healthy volunteers: An open-label, parallel group, randomized clinical study. PLoS One. 2018 Jan 17;13(1):e0191258. doi: 10.1371/journal.pone.0191258. eCollection 2018.
Other Identifiers
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MP0
Identifier Type: -
Identifier Source: org_study_id
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