Correlation Between the Polymorphism ofβ2 AR and the Labor Progress After Labor Analgesia

NCT ID: NCT02708602

Last Updated: 2016-03-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-03-31

Study Completion Date

2016-05-31

Brief Summary

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Labor and delivery is a unique physiological experience of women. Inappropriate length of labor progress during vaginal delivery may produce great risks for mother and fetus. Especially the slow progress is one of the most important reasons for the occurrence of cesarean section during vaginal delivery, which still with a high incidence in recent years.Previous studies have found that there was a significant correlation between the genetic polymorphisms of β 2-adrenergic receptor (β2AR) and the duration of vaginal delivery.Therefore, the researchers intend to investigate the distribution of β2-adrenergic receptor (β2AR) genetic polymorphisms among Chinese parturient and observe the relationship between the genetic polymorphisms and labor process after labor analgesia.

Detailed Description

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Conditions

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Labor Analgesia

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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β2AR Arg16Arg (AA group)

People with β2AR Arg16Arg genotype.

β2AR polymorphism

Intervention Type GENETIC

β2AR Arg16Gly (AG group)

People with β2AR Arg16Gly genotype.

β2AR polymorphism

Intervention Type GENETIC

β2AR Gly16Gly (GG group)

People with β2AR Gly16Gly genotype.

β2AR polymorphism

Intervention Type GENETIC

β2AR Gln27Gln (CC group)

People with β2AR Gln16Gln genotype.

β2AR polymorphism

Intervention Type GENETIC

β2AR Gln27Glu (CG group)

People with β2AR Gln27Glu genotype.

β2AR polymorphism

Intervention Type GENETIC

β2AR Glu27Glu (GG group)

People with β2AR Glu27Glu genotype.

β2AR polymorphism

Intervention Type GENETIC

Interventions

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β2AR polymorphism

Intervention Type GENETIC

Eligibility Criteria

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Inclusion Criteria

* Nulliparous women
* Required labor analgesia
* Chinese
* Spontaneous labor

Exclusion Criteria

* Contraindications for epidural analgesia
* Allergic to opioids and/or local anesthetics
* Failed to performing epidural catheterization
* Organic dysfunction
* Those who were not willing to or could not finish the whole study at any time
* Using or used in the past 14 days of the monoamine oxidase inhibitors
* Alcohol addictive or narcotic dependent patients
* Subjects with a nonvertex presentation or scheduled induction of labor
* Twin gestation and breech presentation
Minimum Eligible Age

23 Years

Maximum Eligible Age

43 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Nanjing Maternity and Child Health Care Hospital

OTHER

Sponsor Role lead

Responsible Party

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Caijuan Li

Nanjing Maternity and Child Health Care Hospital

Responsibility Role PRINCIPAL_INVESTIGATOR

Other Identifiers

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NMCHC2016003

Identifier Type: -

Identifier Source: org_study_id

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