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The Bioavailability of Polyacetylenes From Carrots Study

NCT ID: NCT02696473

Last Updated: 2016-12-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

6 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-03-31

Study Completion Date

2016-09-30

Brief Summary

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Polyacetylenes, compounds found naturally in carrots, have shown promising anti-cancer and anti-inflammatory actions in vitro but have not been tested in vivo. To determine whether the polyacetylenes could have an effect in vivo, this study aims to determine whether they are detectible in human biofluids after the consumption of a portion of carrots and whether a difference is seen between a large and small portion.

Detailed Description

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Volunteers will collect urine samples 24 hours prior to the 'test' day and a stool sample either the night before or the morning of the test session. They will have fasted blood taken before eating a portion of carrots with bread and butter. Further blood samples will be taken at 0.5, 1, 2, 3, 4, 6, 8 and 24 hours. All urine and all stool samples (after 4 hours) will be collected up to 48 hours after the carrot dose. They volunteers will attend two test sessions and will be randomised to receive high and low doses of carrot. At least a week will separate testing sessions.

Conditions

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Healthy

Keywords

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Bioavailability Polyacetylenes Falcarinol Falcarindiol Falcarindiol-3-acetate Carrot Biological Availability

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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High Carrot Dose

The volunteer will eat 250g carrot for breakfast with 2 slices of bread and 10g butter

Group Type EXPERIMENTAL

Carrot

Intervention Type DIETARY_SUPPLEMENT

Low Carrot Dose

The volunteer will eat 100g of carrot for breakfast with 2 slices of bread and 10g butter

Group Type EXPERIMENTAL

Carrot

Intervention Type DIETARY_SUPPLEMENT

Interventions

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Carrot

Intervention Type DIETARY_SUPPLEMENT

Other Intervention Names

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polyacetylene falcarinol falcarindiol falcarindiol-3-acetate

Eligibility Criteria

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Inclusion Criteria

* Healthy adults, BMI between 18.5 and 30

Exclusion Criteria

* Metabolic or gastrointestinal conditions, allergies to carrot or bread, taking any medication that affects metabolism or digestion, smokers
Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Newcastle University

OTHER

Sponsor Role collaborator

Newcastle-upon-Tyne Hospitals NHS Trust

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Sarah Warner

Role: STUDY_DIRECTOR

Newcastle University

Locations

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Clinical Research Facility, Royal Victoria Infirmary

Newcastle upon Tyne, , United Kingdom

Site Status

Countries

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United Kingdom

Other Identifiers

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Carrot_01

Identifier Type: -

Identifier Source: org_study_id