Trial Outcomes & Findings for Improving Function in Older Veterans With Hospital-Associated Deconditioning (NCT NCT02696382)

NCT ID: NCT02696382

Last Updated: 2024-04-01

Results Overview

Will be assessed at the subject's self selected speed for each participant over 4 meters. Faster walking indicates capacity for performance of certain activities (e.g. crossing a street before the light changes).

• Recruitment status: COMPLETED
• Study phase: NA
• Target enrollment: 240 participants
• Primary outcome timeframe: From baseline to 60 days post-baseline
• Results posted on: 2024-04-01

Participant Flow

90 post-consent screen failures

Participant milestones

Measure	Usual Care (UC) Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Overall Study STARTED	75	75
Overall Study 30-Day Assessment	65	69
Overall Study 60-Day Assessment	64	66
Overall Study 90-Day Assessment	63	64
Overall Study COMPLETED	59	54
Overall Study NOT COMPLETED	16	21

Reasons for withdrawal

Measure	Usual Care (UC) Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Overall Study Death	7	2
Overall Study Withdrawal by Subject	5	12
Overall Study Lost to Follow-up	4	7

Baseline Characteristics

Improving Function in Older Veterans With Hospital-Associated Deconditioning

Baseline characteristics by cohort

Measure	Usual Care (UC) n=75 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=75 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Total n=150 Participants Total of all reporting groups
Age, Continuous	76.0 Years n=5 Participants	77.0 Years n=7 Participants	76.5 Years n=5 Participants
Sex: Female, Male Female	6 Participants n=5 Participants	17 Participants n=7 Participants	23 Participants n=5 Participants
Sex: Female, Male Male	69 Participants n=5 Participants	58 Participants n=7 Participants	127 Participants n=5 Participants
Ethnicity (NIH/OMB) Hispanic or Latino	7 Participants n=5 Participants	14 Participants n=7 Participants	21 Participants n=5 Participants
Ethnicity (NIH/OMB) Not Hispanic or Latino	63 Participants n=5 Participants	59 Participants n=7 Participants	122 Participants n=5 Participants
Ethnicity (NIH/OMB) Unknown or Not Reported	5 Participants n=5 Participants	2 Participants n=7 Participants	7 Participants n=5 Participants
Race (NIH/OMB) American Indian or Alaska Native	4 Participants n=5 Participants	2 Participants n=7 Participants	6 Participants n=5 Participants
Race (NIH/OMB) Asian	0 Participants n=5 Participants	0 Participants n=7 Participants	0 Participants n=5 Participants
Race (NIH/OMB) Native Hawaiian or Other Pacific Islander	0 Participants n=5 Participants	0 Participants n=7 Participants	0 Participants n=5 Participants
Race (NIH/OMB) Black or African American	10 Participants n=5 Participants	18 Participants n=7 Participants	28 Participants n=5 Participants
Race (NIH/OMB) White	58 Participants n=5 Participants	50 Participants n=7 Participants	108 Participants n=5 Participants
Race (NIH/OMB) More than one race	2 Participants n=5 Participants	2 Participants n=7 Participants	4 Participants n=5 Participants
Race (NIH/OMB) Unknown or Not Reported	1 Participants n=5 Participants	3 Participants n=7 Participants	4 Participants n=5 Participants
Region of Enrollment United States	75 Participants n=5 Participants	75 Participants n=7 Participants	150 Participants n=5 Participants
Education Less Than High School	5 Participants n=5 Participants	3 Participants n=7 Participants	8 Participants n=5 Participants
Education High School Diploma	17 Participants n=5 Participants	23 Participants n=7 Participants	40 Participants n=5 Participants
Education Some College	21 Participants n=5 Participants	26 Participants n=7 Participants	47 Participants n=5 Participants
Education Associate's	10 Participants n=5 Participants	8 Participants n=7 Participants	18 Participants n=5 Participants
Education Bachelor's/Master's/Doctoral	21 Participants n=5 Participants	15 Participants n=7 Participants	36 Participants n=5 Participants
Education Unknown or Not Reported	1 Participants n=5 Participants	0 Participants n=7 Participants	1 Participants n=5 Participants
Marital Status Single	6 Participants n=5 Participants	9 Participants n=7 Participants	15 Participants n=5 Participants
Marital Status Married/Cohabitating	29 Participants n=5 Participants	33 Participants n=7 Participants	62 Participants n=5 Participants
Marital Status Widowed	13 Participants n=5 Participants	16 Participants n=7 Participants	29 Participants n=5 Participants
Marital Status Divorced/Separated	18 Participants n=5 Participants	16 Participants n=7 Participants	34 Participants n=5 Participants
Marital Status Unknown or Not Reported	9 Participants n=5 Participants	1 Participants n=7 Participants	10 Participants n=5 Participants

PRIMARY outcome

Timeframe: From baseline to 60 days post-baseline

Will be assessed at the subject's self selected speed for each participant over 4 meters. Faster walking indicates capacity for performance of certain activities (e.g. crossing a street before the light changes).

Outcome measures

Measure	Usual Care (UC) n=58 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=59 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Change in Self-Selected Walking Speed	0.08 m/s Interval 0.04 to 0.12	0.08 m/s Interval 0.04 to 0.12

SECONDARY outcome

Timeframe: Baseline

The SPPB is a well-accepted global measure of lower extremity function which consists of a composite measure including walking speed, chair stands, and balance. It is a strong predictor of disability, institutionalization, and morbidity in older adults. The SPPB is comprised of 3 tasks: a hierarchical standing balance test (side-by-side, semi-tandem, and tandem), a 4-meter usual gait speed, and a 5-time sit-to-stand from a standardized chair. Each subtask is scored (based on time) from 0-4 points and then summarized into a total score of 0-12 points, where 12 points represents the highest performance.

Outcome measures

Measure	Usual Care (UC) n=73 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=74 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Short Physical Performance Battery (SPPB)	5.07 score on a scale Standard Deviation 2.50	5.27 score on a scale Standard Deviation 2.54

SECONDARY outcome

Timeframe: 30 Days

The SPPB is a well-accepted global measure of lower extremity function which consists of a composite measure including walking speed, chair stands, and balance. It is a strong predictor of disability, institutionalization, and morbidity in older adults. The SPPB is comprised of 3 tasks: a hierarchical standing balance test (side-by-side, semi-tandem, and tandem), a 4-meter usual gait speed, and a 5-time sit-to-stand from a standardized chair. Each subtask is scored (based on time) from 0-4 points and then summarized into a total score of 0-12 points, where 12 points represents the highest performance.

Outcome measures

Measure	Usual Care (UC) n=61 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=64 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Short Physical Performance Battery (SPPB)	6.46 score on a scale Standard Deviation 3.13	6.22 score on a scale Standard Deviation 2.86

SECONDARY outcome

Timeframe: 60 Days

The SPPB is a well-accepted global measure of lower extremity function which consists of a composite measure including walking speed, chair stands, and balance. It is a strong predictor of disability, institutionalization, and morbidity in older adults. The SPPB is comprised of 3 tasks: a hierarchical standing balance test (side-by-side, semi-tandem, and tandem), a 4-meter usual gait speed, and a 5-time sit-to-stand from a standardized chair. Each subtask is scored (based on time) from 0-4 points and then summarized into a total score of 0-12 points, where 12 points represents the highest performance.

Outcome measures

Measure	Usual Care (UC) n=60 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=61 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Short Physical Performance Battery (SPPB)	6.50 score on a scale Standard Deviation 3.30	6.11 score on a scale Standard Deviation 3.15

SECONDARY outcome

Timeframe: 90 Days

The SPPB is a well-accepted global measure of lower extremity function which consists of a composite measure including walking speed, chair stands, and balance. It is a strong predictor of disability, institutionalization, and morbidity in older adults. The SPPB is comprised of 3 tasks: a hierarchical standing balance test (side-by-side, semi-tandem, and tandem), a 4-meter usual gait speed, and a 5-time sit-to-stand from a standardized chair. Each subtask is scored (based on time) from 0-4 points and then summarized into a total score of 0-12 points, where 12 points represents the highest performance.

Outcome measures

Measure	Usual Care (UC) n=58 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=60 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Short Physical Performance Battery (SPPB)	6.43 score on a scale Standard Deviation 3.27	5.97 score on a scale Standard Deviation 3.05

SECONDARY outcome

Timeframe: 180 Days

The SPPB is a well-accepted global measure of lower extremity function which consists of a composite measure including walking speed, chair stands, and balance. It is a strong predictor of disability, institutionalization, and morbidity in older adults. The SPPB is comprised of 3 tasks: a hierarchical standing balance test (side-by-side, semi-tandem, and tandem), a 4-meter usual gait speed, and a 5-time sit-to-stand from a standardized chair. Each subtask is scored (based on time) from 0-4 points and then summarized into a total score of 0-12 points, where 12 points represents the highest performance.

Outcome measures

Measure	Usual Care (UC) n=57 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=52 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Short Physical Performance Battery (SPPB)	6.82 score on a scale Standard Deviation 3.30	6.46 score on a scale Standard Deviation 3.16

SECONDARY outcome

Timeframe: Baseline

The TUG measures the time it takes a patient to rise from an arm chair (seat height of 46 cm), walk 3 m, turn and return to sitting in the same chair without physical assistance. This test has excellent inter-rater (ICC=0.99) and intra-rater reliability (ICC=0.99), as measured in a group of 60 functionally disabled older adults (mean age 80 years). Faster times indicate a better outcome.

Outcome measures

Measure	Usual Care (UC) n=67 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=65 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Timed-Up-And-Go Test	22.91 seconds Standard Deviation 18.74	19.98 seconds Standard Deviation 11.81

SECONDARY outcome

Timeframe: 30 Days

The TUG measures the time it takes a patient to rise from an arm chair (seat height of 46 cm), walk 3 m, turn and return to sitting in the same chair without physical assistance. This test has excellent inter-rater (ICC=0.99) and intra-rater reliability (ICC=0.99), as measured in a group of 60 functionally disabled older adults (mean age 80 years). Faster times indicate a better outcome.

Outcome measures

Measure	Usual Care (UC) n=55 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=60 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Timed-Up-And-Go Test	16.15 seconds Standard Deviation 9.67	16.15 seconds Standard Deviation 7.61

SECONDARY outcome

Timeframe: 60 Days

The TUG measures the time it takes a patient to rise from an arm chair (seat height of 46 cm), walk 3 m, turn and return to sitting in the same chair without physical assistance. This test has excellent inter-rater (ICC=0.99) and intra-rater reliability (ICC=0.99), as measured in a group of 60 functionally disabled older adults (mean age 80 years). Faster times indicate a better outcome.

Outcome measures

Measure	Usual Care (UC) n=53 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=52 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Timed-Up-And-Go Test	18.47 seconds Standard Deviation 15.32	17.21 seconds Standard Deviation 9.56

SECONDARY outcome

Timeframe: 90 Days

The TUG measures the time it takes a patient to rise from an arm chair (seat height of 46 cm), walk 3 m, turn and return to sitting in the same chair without physical assistance. This test has excellent inter-rater (ICC=0.99) and intra-rater reliability (ICC=0.99), as measured in a group of 60 functionally disabled older adults (mean age 80 years). Faster times indicate a better outcome.

Outcome measures

Measure	Usual Care (UC) n=54 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=52 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Timed-Up-And-Go Test	18.80 seconds Standard Deviation 3.27	17.78 seconds Standard Deviation 14.14

SECONDARY outcome

Timeframe: 180 Days

The TUG measures the time it takes a patient to rise from an arm chair (seat height of 46 cm), walk 3 m, turn and return to sitting in the same chair without physical assistance. This test has excellent inter-rater (ICC=0.99) and intra-rater reliability (ICC=0.99), as measured in a group of 60 functionally disabled older adults (mean age 80 years). Faster times indicate a better outcome.

Outcome measures

Measure	Usual Care (UC) n=49 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=45 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Timed-Up-And-Go Test	15.96 seconds Standard Deviation 8.26	16.61 seconds Standard Deviation 9.73

SECONDARY outcome

Timeframe: Baseline

mPPT assesses 7 tasks. Based on the time it takes to complete each task, a score from 0 (unable to complete) to 4 (performed quickly and easily) is given for each item. The maximal score is 28 and includes tasks that involve upper and lower extremity function. Test-retest reliability for the modified PPT score is 0.96. The instrument is sensitive to change and has been used in exercise trials with frail elders.

Outcome measures

Measure	Usual Care (UC) n=71 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=72 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Modified Physical Performance Test (mPPT)	12.31 score on a scale Standard Deviation 6.57	12.08 score on a scale Standard Deviation 6.29

SECONDARY outcome

Timeframe: 30 Days

mPPT assesses 7 tasks. Based on the time it takes to complete each task, a score from 0 (unable to complete) to 4 (performed quickly and easily) is given for each item. The maximal score is 28 and includes tasks that involve upper and lower extremity function. Test-retest reliability for the modified PPT score is 0.96. The instrument is sensitive to change and has been used in exercise trials with frail elders.

Outcome measures

Measure	Usual Care (UC) n=58 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=62 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Modified Physical Performance Test (mPPT)	16.47 score on a scale Standard Deviation 7.43	15.37 score on a scale Standard Deviation 6.88

SECONDARY outcome

Timeframe: 60 Days

mPPT assesses 7 tasks. Based on the time it takes to complete each task, a score from 0 (unable to complete) to 4 (performed quickly and easily) is given for each item. The maximal score is 28 and includes tasks that involve upper and lower extremity function. Test-retest reliability for the modified PPT score is 0.96. The instrument is sensitive to change and has been used in exercise trials with frail elders.

Outcome measures

Measure	Usual Care (UC) n=57 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=55 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Modified Physical Performance Test (mPPT)	16.04 score on a scale Standard Deviation 7.60	15.38 score on a scale Standard Deviation 6.61

SECONDARY outcome

Timeframe: 90 Days

mPPT assesses 7 tasks. Based on the time it takes to complete each task, a score from 0 (unable to complete) to 4 (performed quickly and easily) is given for each item. The maximal score is 28 and includes tasks that involve upper and lower extremity function. Test-retest reliability for the modified PPT score is 0.96. The instrument is sensitive to change and has been used in exercise trials with frail elders.

Outcome measures

Measure	Usual Care (UC) n=56 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=56 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Modified Physical Performance Test (mPPT)	15.63 score on a scale Standard Deviation 7.32	15.07 score on a scale Standard Deviation 7.4

SECONDARY outcome

Timeframe: 180 Days

mPPT assesses 7 tasks. Based on the time it takes to complete each task, a score from 0 (unable to complete) to 4 (performed quickly and easily) is given for each item. The maximal score is 28 and includes tasks that involve upper and lower extremity function. Test-retest reliability for the modified PPT score is 0.96. The instrument is sensitive to change and has been used in exercise trials with frail elders.

Outcome measures

Measure	Usual Care (UC) n=55 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=47 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Modified Physical Performance Test (mPPT)	15.49 score on a scale Standard Deviation 7.77	16.51 score on a scale Standard Deviation 7.07

SECONDARY outcome

Timeframe: Baseline

Quadriceps muscle strength was tested via hand-held dynamometry (Lafayette Instrument Company, Lafayette, IN), wherein higher numbers indicate greater strength (better outcome). Method established in previous work: The position of the dynamometer was held perpendicular to the limb segment toward which it was directed, and the plate of the dynamometer was placed in the same position on the tested limb each time. The tester manually stabilized the limb segment proximally and provided verbal and visual cues of the muscle contraction prior to the isometric test. Individuals were asked to maintain the maximum effort for 2-3 seconds, at which point the tester told them to stop. Strength for each muscle was tested until two maximal attempts were within 5% of each other, and the highest value, to the nearest tenth of a kg, was used in analysis.

Outcome measures

Measure	Usual Care (UC) n=52 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=54 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Lower Extremity Strength Via Hand-Held Dynamometry: Right Knee Extensor	19.03 kg Standard Deviation 9.32	18.08 kg Standard Deviation 9.10

SECONDARY outcome

Timeframe: 30 Days

Quadriceps muscle strength was tested via hand-held dynamometry (Lafayette Instrument Company, Lafayette, IN), wherein higher numbers indicate greater strength (better outcome). Method established in previous work: The position of the dynamometer was held perpendicular to the limb segment toward which it was directed, and the plate of the dynamometer was placed in the same position on the tested limb each time. The tester manually stabilized the limb segment proximally and provided verbal and visual cues of the muscle contraction prior to the isometric test. Individuals were asked to maintain the maximum effort for 2-3 seconds, at which point the tester told them to stop. Strength for each muscle was tested until two maximal attempts were within 5% of each other, and the highest value, to the nearest tenth of a kg, was used in analysis.

Outcome measures

Measure	Usual Care (UC) n=49 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=53 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Lower Extremity Strength Via Hand-Held Dynamometry: Right Knee Extensor	18.67 kg Standard Deviation 6.12	19.09 kg Standard Deviation 10.07

SECONDARY outcome

Timeframe: 60 Days

Quadriceps muscle strength was tested via hand-held dynamometry (Lafayette Instrument Company, Lafayette, IN), wherein higher numbers indicate greater strength (better outcome). Method established in previous work: The position of the dynamometer was held perpendicular to the limb segment toward which it was directed, and the plate of the dynamometer was placed in the same position on the tested limb each time. The tester manually stabilized the limb segment proximally and provided verbal and visual cues of the muscle contraction prior to the isometric test. Individuals were asked to maintain the maximum effort for 2-3 seconds, at which point the tester told them to stop. Strength for each muscle was tested until two maximal attempts were within 5% of each other, and the highest value, to the nearest tenth of a kg, was used in analysis.

Outcome measures

Measure	Usual Care (UC) n=45 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=48 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Lower Extremity Strength Via Hand-Held Dynamometry: Right Knee Extensor	21.11 kg Standard Deviation 9.04	18.61 kg Standard Deviation 6.80

SECONDARY outcome

Timeframe: 90 Days

Quadriceps muscle strength was tested via hand-held dynamometry (Lafayette Instrument Company, Lafayette, IN), wherein higher numbers indicate greater strength (better outcome). Method established in previous work: The position of the dynamometer was held perpendicular to the limb segment toward which it was directed, and the plate of the dynamometer was placed in the same position on the tested limb each time. The tester manually stabilized the limb segment proximally and provided verbal and visual cues of the muscle contraction prior to the isometric test. Individuals were asked to maintain the maximum effort for 2-3 seconds, at which point the tester told them to stop. Strength for each muscle was tested until two maximal attempts were within 5% of each other, and the highest value, to the nearest tenth of a kg, was used in analysis.

Outcome measures

Measure	Usual Care (UC) n=41 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=43 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Lower Extremity Strength Via Hand-Held Dynamometry: Right Knee Extensor	19.24 kg Standard Deviation 7.57	19.34 kg Standard Deviation 5.13

SECONDARY outcome

Timeframe: 180 Days

Quadriceps muscle strength was tested via hand-held dynamometry (Lafayette Instrument Company, Lafayette, IN), wherein higher numbers indicate greater strength (better outcome). Method established in previous work: The position of the dynamometer was held perpendicular to the limb segment toward which it was directed, and the plate of the dynamometer was placed in the same position on the tested limb each time. The tester manually stabilized the limb segment proximally and provided verbal and visual cues of the muscle contraction prior to the isometric test. Individuals were asked to maintain the maximum effort for 2-3 seconds, at which point the tester told them to stop. Strength for each muscle was tested until two maximal attempts were within 5% of each other, and the highest value, to the nearest tenth of a kg, was used in analysis.

Outcome measures

Measure	Usual Care (UC) n=40 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=37 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Lower Extremity Strength Via Hand-Held Dynamometry: Right Knee Extensor	20.99 kg Standard Deviation 7.76	19.37 kg Standard Deviation 7.18

SECONDARY outcome

Timeframe: Baseline

Quadriceps muscle strength was tested via hand-held dynamometry (Lafayette Instrument Company, Lafayette, IN), wherein higher numbers indicate greater strength (better outcome). Method established in previous work: The position of the dynamometer was held perpendicular to the limb segment toward which it was directed, and the plate of the dynamometer was placed in the same position on the tested limb each time. The tester manually stabilized the limb segment proximally and provided verbal and visual cues of the muscle contraction prior to the isometric test. Individuals were asked to maintain the maximum effort for 2-3 seconds, at which point the tester told them to stop. Strength for each muscle was tested until two maximal attempts were within 5% of each other, and the highest value, to the nearest tenth of a kg, was used in analysis.

Outcome measures

Measure	Usual Care (UC) n=51 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=52 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Lower Extremity Strength Via Hand-Held Dynamometry: Left Knee Extensor	18.64 kg Standard Deviation 8.23	18.73 kg Standard Deviation 10.54

SECONDARY outcome

Timeframe: 30 Days

Quadriceps muscle strength was tested via hand-held dynamometry (Lafayette Instrument Company, Lafayette, IN), wherein higher numbers indicate greater strength (better outcome). Method established in previous work: The position of the dynamometer was held perpendicular to the limb segment toward which it was directed, and the plate of the dynamometer was placed in the same position on the tested limb each time. The tester manually stabilized the limb segment proximally and provided verbal and visual cues of the muscle contraction prior to the isometric test. Individuals were asked to maintain the maximum effort for 2-3 seconds, at which point the tester told them to stop. Strength for each muscle was tested until two maximal attempts were within 5% of each other, and the highest value, to the nearest tenth of a kg, was used in analysis.

Outcome measures

Measure	Usual Care (UC) n=49 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=51 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Lower Extremity Strength Via Hand-Held Dynamometry: Left Knee Extensor	18.17 kg Standard Deviation 6.28	19.80 kg Standard Deviation 10.28

SECONDARY outcome

Timeframe: 60 Days

Quadriceps muscle strength was tested via hand-held dynamometry (Lafayette Instrument Company, Lafayette, IN), wherein higher numbers indicate greater strength (better outcome). Method established in previous work: The position of the dynamometer was held perpendicular to the limb segment toward which it was directed, and the plate of the dynamometer was placed in the same position on the tested limb each time. The tester manually stabilized the limb segment proximally and provided verbal and visual cues of the muscle contraction prior to the isometric test. Individuals were asked to maintain the maximum effort for 2-3 seconds, at which point the tester told them to stop. Strength for each muscle was tested until two maximal attempts were within 5% of each other, and the highest value, to the nearest tenth of a kg, was used in analysis.

Outcome measures

Measure	Usual Care (UC) n=46 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=47 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Lower Extremity Strength Via Hand-Held Dynamometry: Left Knee Extensor	20.52 kg Standard Deviation 8.29	18.13 kg Standard Deviation 7.16

SECONDARY outcome

Timeframe: 90 Days

Quadriceps muscle strength was tested via hand-held dynamometry (Lafayette Instrument Company, Lafayette, IN), wherein higher numbers indicate greater strength (better outcome). Method established in previous work: The position of the dynamometer was held perpendicular to the limb segment toward which it was directed, and the plate of the dynamometer was placed in the same position on the tested limb each time. The tester manually stabilized the limb segment proximally and provided verbal and visual cues of the muscle contraction prior to the isometric test. Individuals were asked to maintain the maximum effort for 2-3 seconds, at which point the tester told them to stop. Strength for each muscle was tested until two maximal attempts were within 5% of each other, and the highest value, to the nearest tenth of a kg, was used in analysis.

Outcome measures

Measure	Usual Care (UC) n=42 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=43 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Lower Extremity Strength Via Hand-Held Dynamometry: Left Knee Extensor	17.74 kg Standard Deviation 6.72	18.93 kg Standard Deviation 6.55

SECONDARY outcome

Timeframe: 180 Days

Quadriceps muscle strength was tested via hand-held dynamometry (Lafayette Instrument Company, Lafayette, IN), wherein higher numbers indicate greater strength (better outcome). Method established in previous work: The position of the dynamometer was held perpendicular to the limb segment toward which it was directed, and the plate of the dynamometer was placed in the same position on the tested limb each time. The tester manually stabilized the limb segment proximally and provided verbal and visual cues of the muscle contraction prior to the isometric test. Individuals were asked to maintain the maximum effort for 2-3 seconds, at which point the tester told them to stop. Strength for each muscle was tested until two maximal attempts were within 5% of each other, and the highest value, to the nearest tenth of a kg, was used in analysis.

Outcome measures

Measure	Usual Care (UC) n=39 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=36 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Lower Extremity Strength Via Hand-Held Dynamometry: Left Knee Extensor	19.86 kg Standard Deviation 6.57	19.52 kg Standard Deviation 7.91

SECONDARY outcome

Timeframe: Baseline

Grip strength was measured on the dominant hand using a hand dynamometer with the participant seated and elbow positioned at 90 degrees of flexion with the arm resting against the trunk. Maximal grip strength during a 3 second hold was measured for at least 2 trials and a 3rd trial was allowed if differences between trials were > 5%. Higher numbers indicate greater strength (better outcome).

Outcome measures

Measure	Usual Care (UC) n=66 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=64 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Grip Strength: Dominant Hand	24.60 kg Standard Deviation 8.98	27.94 kg Standard Deviation 13.10

SECONDARY outcome

Timeframe: 30 Days

Grip strength was measured on the dominant hand using a hand dynamometer with the participant seated and elbow positioned at 90 degrees of flexion with the arm resting against the trunk. Maximal grip strength during a 3 second hold was measured for at least 2 trials and a 3rd trial was allowed if differences between trials were > 5%. Higher numbers indicate greater strength (better outcome).

Outcome measures

Measure	Usual Care (UC) n=58 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=62 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Grip Strength: Dominant Hand	26.06 kg Standard Deviation 9.34	26.21 kg Standard Deviation 11.31

SECONDARY outcome

Timeframe: 60 Days

Grip strength was measured on the dominant hand using a hand dynamometer with the participant seated and elbow positioned at 90 degrees of flexion with the arm resting against the trunk. Maximal grip strength during a 3 second hold was measured for at least 2 trials and a 3rd trial was allowed if differences between trials were > 5%. Higher numbers indicate greater strength (better outcome).

Outcome measures

Measure	Usual Care (UC) n=58 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=59 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Grip Strength: Dominant Hand	26.57 kg Standard Deviation 8.70	25.81 kg Standard Deviation 10.77

SECONDARY outcome

Timeframe: 90 Days

Grip strength was measured on the dominant hand using a hand dynamometer with the participant seated and elbow positioned at 90 degrees of flexion with the arm resting against the trunk. Maximal grip strength during a 3 second hold was measured for at least 2 trials and a 3rd trial was allowed if differences between trials were > 5%. Higher numbers indicate greater strength (better outcome).

Outcome measures

Measure	Usual Care (UC) n=55 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=56 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Grip Strength: Dominant Hand	26.13 kg Standard Deviation 7.22	27.35 kg Standard Deviation 11.75

SECONDARY outcome

Timeframe: 180 Days

Grip strength was measured on the dominant hand using a hand dynamometer with the participant seated and elbow positioned at 90 degrees of flexion with the arm resting against the trunk. Maximal grip strength during a 3 second hold was measured for at least 2 trials and a 3rd trial was allowed if differences between trials were > 5%. Higher numbers indicate greater strength (better outcome).

Outcome measures

Measure	Usual Care (UC) n=50 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=51 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Grip Strength: Dominant Hand	26.15 kg Standard Deviation 8.03	27.86 kg Standard Deviation 10.98

SECONDARY outcome

Timeframe: Baseline

Will be assessed at the subject's self selected speed for each participant over 4 meters. Faster walking indicates capacity for performance of certain activities (e.g. crossing a street before the light changes).

Outcome measures

Measure	Usual Care (UC) n=73 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=74 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Self-Selected Walking Speed	0.49 m/s Standard Deviation 0.19	0.50 m/s Standard Deviation 0.17

SECONDARY outcome

Timeframe: 30 Days

Will be assessed at the subject's self selected speed for each participant over 4 meters. Faster walking indicates capacity for performance of certain activities (e.g. crossing a street before the light changes).

Outcome measures

Measure	Usual Care (UC) n=59 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=65 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Self-Selected Walking Speed	0.59 m/s Standard Deviation 0.20	0.57 m/s Standard Deviation 0.22

SECONDARY outcome

Timeframe: 90 Days

Will be assessed at the subject's self selected speed for each participant over 4 meters. Faster walking indicates capacity for performance of certain activities (e.g. crossing a street before the light changes).

Outcome measures

Measure	Usual Care (UC) n=59 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=59 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Self-Selected Walking Speed	0.61 m/s Standard Deviation 0.22	0.60 m/s Standard Deviation 0.27

SECONDARY outcome

Timeframe: 180 Days

Will be assessed at the subject's self selected speed for each participant over 4 meters. Faster walking indicates capacity for performance of certain activities (e.g. crossing a street before the light changes).

Outcome measures

Measure	Usual Care (UC) n=57 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=52 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Self-Selected Walking Speed	0.63 m/s Standard Deviation 0.24	0.60 m/s Standard Deviation 0.23

OTHER_PRE_SPECIFIED outcome

Timeframe: Baseline

A self-administered, validated survey identifying patient motivation levels regarding their healthcare. The PAM survey can reliably predict ER visits, hospital admissions, and medication/ therapy adherence. The final score is a composite score of the available 13 items, ranging from 0-100, wherein a higher score indicates a higher activation (better outcomes).

Outcome measures

Measure	Usual Care (UC) n=69 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=71 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Patient Activation Measure Survey (PAM)	60.82 score on a scale Standard Deviation 13.04	62.13 score on a scale Standard Deviation 14.04

OTHER_PRE_SPECIFIED outcome

Timeframe: Baseline

Population: Activity monitor placement was deferred for those participants who declined placement, demonstrated impaired skin integrity, or were unable to understand instructions.

Mounted, tri-axial accelerometer activPAL (PAL Technologies Ltd, Glasgow, UK) was used to capture steps. The activPAL was mounted following completion of the associated assessment and was set to record physical activity for a 24-hour/day, 10-day wear protocol. Data was analyzed with the CREA algorithm (PAL Technologies Ltd) to determine valid wear days. Average step count across valid wear days was used for analysis.

Outcome measures

Measure	Usual Care (UC) n=45 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=53 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Step Count	2298.56 steps per day Standard Deviation 1774.04	2190.65 steps per day Standard Deviation 1367.09

OTHER_PRE_SPECIFIED outcome

Timeframe: 60 Days

Population: Activity monitor placement was deferred for those participants who declined placement, demonstrated impaired skin integrity, or were unable to understand instructions.

Mounted, tri-axial accelerometer activPAL (PAL Technologies Ltd, Glasgow, UK) was used to capture steps. The activPAL was mounted following completion of the associated assessment and was set to record physical activity for a 24-hour/day, 10-day wear protocol. Data was analyzed with the CREA algorithm (PAL Technologies Ltd) to determine valid wear days. Average step count across valid wear days was used for analysis.

Outcome measures

Measure	Usual Care (UC) n=34 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=36 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Step Count	3098.33 steps per day Standard Deviation 2125.86	2724.17 steps per day Standard Deviation 1675.40

OTHER_PRE_SPECIFIED outcome

Timeframe: 180 Days

Population: Activity monitor placement was deferred for those participants who declined placement, demonstrated impaired skin integrity, or were unable to understand instructions.

Mounted, tri-axial accelerometer activPAL (PAL Technologies Ltd, Glasgow, UK) was used to capture steps. The activPAL was mounted following completion of the associated assessment and was set to record physical activity for a 24-hour/day, 10-day wear protocol. Data was analyzed with the CREA algorithm (PAL Technologies Ltd) to determine valid wear days. Average step count across valid wear days was used for analysis.

Outcome measures

Measure	Usual Care (UC) n=30 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=32 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
Step Count	2410.59 steps per day Standard Deviation 1737.08	2583.33 steps per day Standard Deviation 1403.92

OTHER_PRE_SPECIFIED outcome

Timeframe: Baseline

The Life-Space Assessment survey is a self-reported measure assessing a patient's movement, extending from within the home to beyond a patient's town or geographic region during the prior 4 weeks. The composite score (summed) ranges from 0 to 120, with higher scores representing greater mobility.

Outcome measures

Measure	Usual Care (UC) n=62 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=63 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
The Life-Space Assessment Survey	34.01 score on a scale Standard Deviation 16.43	32.13 score on a scale Standard Deviation 16.69

OTHER_PRE_SPECIFIED outcome

Timeframe: 30 Days

The Life-Space Assessment survey is a self-reported measure assessing a patient's movement, extending from within the home to beyond a patient's town or geographic region during the prior 4 weeks. The composite score (summed) ranges from 0 to 120, with higher scores representing greater mobility.

Outcome measures

Measure	Usual Care (UC) n=57 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=58 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
The Life-Space Assessment Survey	39.79 score on a scale Standard Deviation 15.75	39.71 score on a scale Standard Deviation 15.91

OTHER_PRE_SPECIFIED outcome

Timeframe: 60 Days

The Life-Space Assessment survey is a self-reported measure assessing a patient's movement, extending from within the home to beyond a patient's town or geographic region during the prior 4 weeks. The composite score (summed) ranges from 0 to 120, with higher scores representing greater mobility.

Outcome measures

Measure	Usual Care (UC) n=59 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=56 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
The Life-Space Assessment Survey	40.92 score on a scale Standard Deviation 41.56	38.71 score on a scale Standard Deviation 19.99

OTHER_PRE_SPECIFIED outcome

Timeframe: 90 Days

The Life-Space Assessment survey is a self-reported measure assessing a patient's movement, extending from within the home to beyond a patient's town or geographic region during the prior 4 weeks. The composite score (summed) ranges from 0 to 120, with higher scores representing greater mobility.

Outcome measures

Measure	Usual Care (UC) n=53 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=57 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
The Life-Space Assessment Survey	41.57 score on a scale Standard Deviation 16.70	40.54 score on a scale Standard Deviation 17.61

OTHER_PRE_SPECIFIED outcome

Timeframe: 180 Days

The Life-Space Assessment survey is a self-reported measure assessing a patient's movement, extending from within the home to beyond a patient's town or geographic region during the prior 4 weeks. The composite score (summed) ranges from 0 to 120, with higher scores representing greater mobility.

Outcome measures

Measure	Usual Care (UC) n=54 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=45 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
The Life-Space Assessment Survey	42.62 score on a scale Standard Deviation 20.40	40.17 score on a scale Standard Deviation 39.00

OTHER_PRE_SPECIFIED outcome

Timeframe: Baseline

The Veterans RAND 12 Item Health Survey (VR-12) is a patient-reported global health measure that is used to assess a patient's overall perspective of their health. The questions in this survey correspond to seven different health domains: general health perceptions, physical functioning, role limitations due to physical and emotional problems, bodily pain, energy/fatigue levels, social functioning and mental health. Answers are summarized into two scores, a Physical Component Score (PCS) and a Mental Component Score (MCS) which then provides an important contrast between the respondents' physical and psychological health status. Each component score is summarized from 0 to 100, with a higher score indicating a better outcome.

Outcome measures

Measure	Usual Care (UC) n=72 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=74 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
The Veterans Rand 12 Items Health Survey (VR-12): Physical Component Score (PCS)	29.34 score on a scale Standard Deviation 8.64	28.82 score on a scale Standard Deviation 9.29

OTHER_PRE_SPECIFIED outcome

Timeframe: 60 Days

The Veterans RAND 12 Item Health Survey (VR-12) is a patient-reported global health measure that is used to assess a patient's overall perspective of their health. The questions in this survey correspond to seven different health domains: general health perceptions, physical functioning, role limitations due to physical and emotional problems, bodily pain, energy/fatigue levels, social functioning and mental health. Answers are summarized into two scores, a Physical Component Score (PCS) and a Mental Component Score (MCS) which then provides an important contrast between the respondents' physical and psychological health status. Each component score is summarized from 0 to 100, with a higher score indicating a better outcome.

Outcome measures

Measure	Usual Care (UC) n=61 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=60 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
The Veterans Rand 12 Items Health Survey (VR-12): Physical Component Score (PCS)	32.94 score on a scale Standard Deviation 10.28	32.41 score on a scale Standard Deviation 11.58

OTHER_PRE_SPECIFIED outcome

Timeframe: 180 Days

The Veterans RAND 12 Item Health Survey (VR-12) is a patient-reported global health measure that is used to assess a patient's overall perspective of their health. The questions in this survey correspond to seven different health domains: general health perceptions, physical functioning, role limitations due to physical and emotional problems, bodily pain, energy/fatigue levels, social functioning and mental health. Answers are summarized into two scores, a Physical Component Score (PCS) and a Mental Component Score (MCS) which then provides an important contrast between the respondents' physical and psychological health status. Each component score is summarized from 0 to 100, with a higher score indicating a better outcome.

Outcome measures

Measure	Usual Care (UC) n=54 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=49 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
The Veterans Rand 12 Items Health Survey (VR-12): Physical Component Score (PCS)	33.77 score on a scale Standard Deviation 10.80	32.55 score on a scale Standard Deviation 10.60

OTHER_PRE_SPECIFIED outcome

Timeframe: Baseline

The Veterans RAND 12 Item Health Survey (VR-12) is a patient-reported global health measure that is used to assess a patient's overall perspective of their health. The questions in this survey correspond to seven different health domains: general health perceptions, physical functioning, role limitations due to physical and emotional problems, bodily pain, energy/fatigue levels, social functioning and mental health. Answers are summarized into two scores, a Physical Component Score (PCS) and a Mental Component Score (MCS) which then provides an important contrast between the respondents' physical and psychological health status. Each component score is summarized from 0 to 100, with a higher score indicating a better outcome.

Outcome measures

Measure	Usual Care (UC) n=72 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=73 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
The Veterans Rand 12 Items Health Survey (VR-12): Mental Component Score (MCS)	45.83 score on a scale Standard Deviation 12.34	45.03 score on a scale Standard Deviation 12.94

OTHER_PRE_SPECIFIED outcome

Timeframe: 60 Days

The Veterans RAND 12 Item Health Survey (VR-12) is a patient-reported global health measure that is used to assess a patient's overall perspective of their health. The questions in this survey correspond to seven different health domains: general health perceptions, physical functioning, role limitations due to physical and emotional problems, bodily pain, energy/fatigue levels, social functioning and mental health. Answers are summarized into two scores, a Physical Component Score (PCS) and a Mental Component Score (MCS) which then provides an important contrast between the respondents' physical and psychological health status. Each component score is summarized from 0 to 100, with a higher score indicating a better outcome.

Outcome measures

Measure	Usual Care (UC) n=60 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=60 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
The Veterans Rand 12 Items Health Survey (VR-12): Mental Component Score (MCS)	48.83 score on a scale Standard Deviation 12.91	45.30 score on a scale Standard Deviation 15.04

OTHER_PRE_SPECIFIED outcome

Timeframe: 180 Days

The Veterans RAND 12 Item Health Survey (VR-12) is a patient-reported global health measure that is used to assess a patient's overall perspective of their health. The questions in this survey correspond to seven different health domains: general health perceptions, physical functioning, role limitations due to physical and emotional problems, bodily pain, energy/fatigue levels, social functioning and mental health. Answers are summarized into two scores, a Physical Component Score (PCS) and a Mental Component Score (MCS) which then provides an important contrast between the respondents' physical and psychological health status. Each component score is summarized from 0 to 100, with a higher score indicating a better outcome.

Outcome measures

Measure	Usual Care (UC) n=54 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=49 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
The Veterans Rand 12 Items Health Survey (VR-12): Mental Component Score (MCS)	50.70 score on a scale Standard Deviation 11.53	44.13 score on a scale Standard Deviation 12.36

OTHER_PRE_SPECIFIED outcome

Timeframe: Baseline

SLUMS screens for cognitive impairments by assessing participant function in the areas of attention, calculation, immediate and delayed recall, animal naming, and visuospatial skills. Scores range from 0 to 30, wherein a higher score indicates less cognitive impairment. Scores of 27 to 30 are considered normal in a person with a high school education. Scores between 21 and 26 suggest a mild neurocognitive disorder. Scores between 0 and 20 indicate dementia.

Outcome measures

Measure	Usual Care (UC) n=71 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=74 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
St. Louis University Mental Status Examination (SLUMS)	22.68 score on a scale Standard Deviation 4.14	22.28 score on a scale Standard Deviation 4.30

OTHER_PRE_SPECIFIED outcome

Timeframe: 60 Days

SLUMS screens for cognitive impairments by assessing participant function in the areas of attention, calculation, immediate and delayed recall, animal naming, and visuospatial skills. Scores range from 0 to 30, wherein a higher score indicates less cognitive impairment. Scores of 27 to 30 are considered normal in a person with a high school education. Scores between 21 and 26 suggest a mild neurocognitive disorder. Scores between 0 and 20 indicate dementia.

Outcome measures

Measure	Usual Care (UC) n=58 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=59 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
St. Louis University Mental Status Examination (SLUMS)	23.17 score on a scale Standard Deviation 4.78	22.49 score on a scale Standard Deviation 4.78

OTHER_PRE_SPECIFIED outcome

Timeframe: 180 Days

SLUMS screens for cognitive impairments by assessing participant function in the areas of attention, calculation, immediate and delayed recall, animal naming, and visuospatial skills. Scores range from 0 to 30, wherein a higher score indicates less cognitive impairment. Scores of 27 to 30 are considered normal in a person with a high school education. Scores between 21 and 26 suggest a mild neurocognitive disorder. Scores between 0 and 20 indicate dementia.

Outcome measures

Measure	Usual Care (UC) n=51 Participants Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=49 Participants Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
St. Louis University Mental Status Examination (SLUMS)	23.86 score on a scale Standard Deviation 4.40	22.59 score on a scale Standard Deviation 5.01

Adverse Events

Usual Care (UC)

Serious events: 33 serious events

Other events: 46 other events

Deaths: 7 deaths

Progressive High Intensity Therapy

Serious events: 34 serious events

Other events: 47 other events

Deaths: 2 deaths

Serious adverse events

Measure	Usual Care (UC) n=75 participants at risk Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=75 participants at risk Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
General disorders Death	9.3% 7/75 • Number of events 7 • Adverse event data were collected from the time of enrollment to 6 months following baseline assessment. Adverse events were collected via questionnaire every 30 days for 180 days following baseline assessment. The questionnaire included questions regarding expected adverse events: falls, ED visits, and hospitalizations.	2.7% 2/75 • Number of events 2 • Adverse event data were collected from the time of enrollment to 6 months following baseline assessment. Adverse events were collected via questionnaire every 30 days for 180 days following baseline assessment. The questionnaire included questions regarding expected adverse events: falls, ED visits, and hospitalizations.
General disorders Inpatient Hospitalization	40.0% 30/75 • Number of events 54 • Adverse event data were collected from the time of enrollment to 6 months following baseline assessment. Adverse events were collected via questionnaire every 30 days for 180 days following baseline assessment. The questionnaire included questions regarding expected adverse events: falls, ED visits, and hospitalizations.	44.0% 33/75 • Number of events 49 • Adverse event data were collected from the time of enrollment to 6 months following baseline assessment. Adverse events were collected via questionnaire every 30 days for 180 days following baseline assessment. The questionnaire included questions regarding expected adverse events: falls, ED visits, and hospitalizations.

Other adverse events

Measure	Usual Care (UC) n=75 participants at risk Participants in the "Usual Care" (UC) group received standard, low-intensity physical therapy following discharge from acute hospitalization. Usual Care (UC): Participants in the "Usual Care" group received standard physical therapy following discharge from acute hospitalization. The activities of therapy included basic strength training, single-planar motor control and gait exercises, and activities of daily living training. Participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.	Progressive High Intensity Therapy n=75 participants at risk Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. Progressive High Intensity Therapy (PHIT): Participants in the "Progressive High Intensity Therapy" (PHIT) group received high intensity physical therapy following discharge from acute hospitalization. The activities of training included progressive resistance training, multi-planar motor control and gait exercises, and high intensity activities of daily living training. Like the Usual Care group, the PHIT participants received 12 intervention visits over 4 weeks (3 visits per week). Participants also received a standardized home exercise program.
General disorders Falls	46.7% 35/75 • Number of events 82 • Adverse event data were collected from the time of enrollment to 6 months following baseline assessment. Adverse events were collected via questionnaire every 30 days for 180 days following baseline assessment. The questionnaire included questions regarding expected adverse events: falls, ED visits, and hospitalizations.	41.3% 31/75 • Number of events 91 • Adverse event data were collected from the time of enrollment to 6 months following baseline assessment. Adverse events were collected via questionnaire every 30 days for 180 days following baseline assessment. The questionnaire included questions regarding expected adverse events: falls, ED visits, and hospitalizations.
General disorders ED Visit Not Requiring Hospitalization	44.0% 33/75 • Number of events 53 • Adverse event data were collected from the time of enrollment to 6 months following baseline assessment. Adverse events were collected via questionnaire every 30 days for 180 days following baseline assessment. The questionnaire included questions regarding expected adverse events: falls, ED visits, and hospitalizations.	40.0% 30/75 • Number of events 58 • Adverse event data were collected from the time of enrollment to 6 months following baseline assessment. Adverse events were collected via questionnaire every 30 days for 180 days following baseline assessment. The questionnaire included questions regarding expected adverse events: falls, ED visits, and hospitalizations.

Additional Information

Dr. Jennifer Stevens-Lapsley

University of Colorado Denver

Phone: 303.724.9170

Email: jennifer.stevens-lapsley@cuanschutz.edu

Results disclosure agreements

• Principal investigator is a sponsor employee
• Publication restrictions are in place