Hormone KLOTHO Level in Heart Failure Patients That Participate in Rehabilitation Programme
NCT ID: NCT02696005
Last Updated: 2016-03-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
30 participants
OBSERVATIONAL
2016-03-31
2017-03-31
Brief Summary
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After completion of 3-month Rehabilitation Programme the second set of labs and Echo measurements will be taken.
Than participants will be divided for 2 groups: the patients who wish to continue Rehabilitation programme for additional 3-month period and the second group that prefer to stop Rehabilitation programme after completion of the first 3 month period.
For both groups additional set of labs will be taken this time and at the end of the study.
The Aim of the study: to investigate association between serum KLOTHO level, physical activity and possible correlation with laboratory and echocardiographic parameters in cohort of Heart Failure patients.
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Detailed Description
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After completion of 3-months Exercise based Rehabilitation Programme set at 70-80% of maximal individual exercise capacity,a second identical set of lab tests and Echo measurements will be performed.
After than participants will be divided into 2 groups: Group I will comprise patients who wish to continue Rehabilitation programme for additional 3-months period and the Group II those who will stop Exercise Rehabilitation programme following completion of the first 3 months.
Both groups will undergo additional set of lab tests at this six-months-point. Except for the primary and secondary end-points all possible correlations between serum KLOTHO level and age, sex, Ejection Fraction, functional capacity, N terminal -Pro B-Type Natriuretic Peptide hormone activity hormone level and kidney function indices will be evaluated.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Group I
15 patients who will continue participation in Exercise- Based Cardiac Rehabilitation Programme after completion initial 3-months period.
Exercise- Based Cardiac Rehabilitation Programme
Exercise- Based Cardiac Rehabilitation Programme for patients suffering from Heart Failure.
Group II
15 patients who will stop participation in Exercise- Based Cardiac Rehabilitation Programme after the initial 3-months period.
Exercise- Based Cardiac Rehabilitation Programme
Exercise- Based Cardiac Rehabilitation Programme for patients suffering from Heart Failure.
Interventions
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Exercise- Based Cardiac Rehabilitation Programme
Exercise- Based Cardiac Rehabilitation Programme for patients suffering from Heart Failure.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
2. Patients ≥ than 18 years
3. Ejection Fraction ≤ than 40 %
Exclusion Criteria
2. Renal failure with Creatinine ≥ 1.5 mg/dl
3. Known Inflammatory condition.
4. Patient taking Calcium Supplement,Vitamin D or pyrophosphate.
18 Years
ALL
No
Sponsors
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Bnai Zion Medical Center
OTHER_GOV
Responsible Party
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Principal Investigators
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Eugeny Radzishevsky, MD
Role: PRINCIPAL_INVESTIGATOR
Bnai Zion Medical Center- Ministry of Health, Israel
Central Contacts
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Other Identifiers
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109-15-BNZ
Identifier Type: -
Identifier Source: org_study_id
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