Trial Outcomes & Findings for Comparing the Ketogenic Effect of Coconut Oil and Different MCTs (NCT NCT02679222)
NCT ID: NCT02679222
Last Updated: 2020-04-06
Results Overview
Total ketones = Plasma acetoacetate (µmol/L) + beta-hydroxybutyrate (µmol/L) measured over a 8 hour period (i.e. daily mean). Samples are taken every 30 minutes on a 8 hours period. The mean is reported here.
Recruitment status
COMPLETED
Study phase
NA
Target enrollment
10 participants
Primary outcome timeframe
8 hours
Results posted on
2020-04-06
Participant Flow
Participant milestones
| Measure |
Supplementation
Protocol involved seven separate but identical metabolic study days for each participant. the test substances were evaluated in random order: vehicle (Control) or 20 mL of the test oils (Coconut oil; tricaprin; tricaprylin; MCT \[tricaprylin/tricaprin\]; coconut oil + MCT \[50:50\]; Coconut oil + tricaprylin \[50:50\]) taken twice, once at breakfast and once at mid-day.
Coconut oil: 20 g of coconut oil
Coconut oil + MCT: 10 g of coconut oil + 10 g of MCT (60 of C8 + 40 of C10)
MCT: 20 g of MCT (60 of C8+40 of C10)
Coconut oil + tricaprylin: 10 g coconut oil + 10 g tricaprylin
Tricaprylin: 20 g tricaprylin
Tricaprin: 20 g tricaprin
Control: No supplement taken on this visit
|
|---|---|
|
Overall Study
STARTED
|
10
|
|
Overall Study
COMPLETED
|
9
|
|
Overall Study
NOT COMPLETED
|
1
|
Reasons for withdrawal
| Measure |
Supplementation
Protocol involved seven separate but identical metabolic study days for each participant. the test substances were evaluated in random order: vehicle (Control) or 20 mL of the test oils (Coconut oil; tricaprin; tricaprylin; MCT \[tricaprylin/tricaprin\]; coconut oil + MCT \[50:50\]; Coconut oil + tricaprylin \[50:50\]) taken twice, once at breakfast and once at mid-day.
Coconut oil: 20 g of coconut oil
Coconut oil + MCT: 10 g of coconut oil + 10 g of MCT (60 of C8 + 40 of C10)
MCT: 20 g of MCT (60 of C8+40 of C10)
Coconut oil + tricaprylin: 10 g coconut oil + 10 g tricaprylin
Tricaprylin: 20 g tricaprylin
Tricaprin: 20 g tricaprin
Control: No supplement taken on this visit
|
|---|---|
|
Overall Study
No time for project
|
1
|
Baseline Characteristics
Race and Ethnicity were not collected from any participant.
Baseline characteristics by cohort
| Measure |
Supplementation
n=9 Participants
Protocol involved seven separate but identical metabolic study days for each participant. the test substances were evaluated in random order: vehicle (Control) or 20 mL of the test oils (Coconut oil; tricaprin; tricaprylin; MCT \[tricaprylin/tricaprin\]; coconut oil + MCT \[50:50\]; Coconut oil + tricaprylin \[50:50\]) taken twice, once at breakfast and once at mid-day.
Coconut oil: 20 g of coconut oil
Coconut oil + MCT: 10 g of coconut oil + 10 g of MCT (60 of C8 + 40 of C10)
MCT: 20 g of MCT (60 of C8+40 of C10)
Coconut oil + tricaprylin: 10 g coconut oil + 10 g tricaprylin
Tricaprylin: 20 g tricaprylin
Tricaprin: 20 g tricaprin
Control: No supplement taken on this visit
|
|---|---|
|
Age, Continuous
|
34 years
STANDARD_DEVIATION 12 • n=9 Participants
|
|
Sex: Female, Male
Female
|
4 Participants
n=9 Participants
|
|
Sex: Female, Male
Male
|
5 Participants
n=9 Participants
|
|
Region of Enrollment
Canada
|
9 Participants
n=9 Participants
|
|
Body mass index
|
24 kg/m^2
STANDARD_DEVIATION 3 • n=9 Participants
|
|
Glucose
|
4.3 mmol/L
STANDARD_DEVIATION 0.2 • n=9 Participants
|
|
Ketones
|
90 µmol/L
STANDARD_DEVIATION 61 • n=9 Participants
|
PRIMARY outcome
Timeframe: 8 hoursTotal ketones = Plasma acetoacetate (µmol/L) + beta-hydroxybutyrate (µmol/L) measured over a 8 hour period (i.e. daily mean). Samples are taken every 30 minutes on a 8 hours period. The mean is reported here.
Outcome measures
| Measure |
Control
n=9 Participants
vehicle (Control) taken twice, once at breakfast and once at mid-day.
Control: No supplement taken on this visit
|
Medium Chain Triglyceride
n=9 Participants
20 mL of MCT taken twice, once at breakfast and once at mid-day.
MCT: 20 g of MCT (60 of C8+40 of C10)
|
Tricaprin
n=9 Participants
20 mL of MCT tricaprin taken twice, once at breakfast and once at mid-day.
Tricaprin: 20 g tricaprin
|
Tricaprylin
n=9 Participants
20 mL of tricaprylin taken twice, once at breakfast and once at mid-day.
Tricaprylin: 20 g tricaprylin
|
Coconut Oil
n=9 Participants
20 mL of Coconut oil taken twice, once at breakfast and once at mid-day.
Coconut oil: 20 g of coconut oil
|
Coconut Oil + MCT
n=9 Participants
20 mL of coconut oil + MCT taken twice, once at breakfast and once at mid-day.
Coconut oil + MCT: 10 g of coconut oil + 10 g of MCT (60 of C8 + 40 of C10)
|
Coconut Oil + Tricaprylin
n=9 Participants
20 mL of Coconut oil + tricaprylin \[50:50\]) taken twice, once at breakfast and once at mid-day.
Coconut oil + tricaprylin: 10 g coconut oil + 10 g tricaprylin
|
|---|---|---|---|---|---|---|---|
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Plasma Ketone Concentrations
|
69 µmol/L
Standard Deviation 92
|
294 µmol/L
Standard Deviation 85
|
109 µmol/L
Standard Deviation 41
|
363 µmol/L
Standard Deviation 109
|
107 µmol/L
Standard Deviation 97
|
141 µmol/L
Standard Deviation 39
|
235 µmol/L
Standard Deviation 79
|
SECONDARY outcome
Timeframe: 8 hoursPlasma ratio of acetoacetate (µmol/L)/ beta-hydroxybutyrate (µmol/L) measured over a 8 hour period (i.e area-under-the-curve over 8 hours).
Outcome measures
| Measure |
Control
n=9 Participants
vehicle (Control) taken twice, once at breakfast and once at mid-day.
Control: No supplement taken on this visit
|
Medium Chain Triglyceride
n=9 Participants
20 mL of MCT taken twice, once at breakfast and once at mid-day.
MCT: 20 g of MCT (60 of C8+40 of C10)
|
Tricaprin
n=9 Participants
20 mL of MCT tricaprin taken twice, once at breakfast and once at mid-day.
Tricaprin: 20 g tricaprin
|
Tricaprylin
n=9 Participants
20 mL of tricaprylin taken twice, once at breakfast and once at mid-day.
Tricaprylin: 20 g tricaprylin
|
Coconut Oil
n=9 Participants
20 mL of Coconut oil taken twice, once at breakfast and once at mid-day.
Coconut oil: 20 g of coconut oil
|
Coconut Oil + MCT
n=9 Participants
20 mL of coconut oil + MCT taken twice, once at breakfast and once at mid-day.
Coconut oil + MCT: 10 g of coconut oil + 10 g of MCT (60 of C8 + 40 of C10)
|
Coconut Oil + Tricaprylin
n=9 Participants
20 mL of Coconut oil + tricaprylin \[50:50\]) taken twice, once at breakfast and once at mid-day.
Coconut oil + tricaprylin: 10 g coconut oil + 10 g tricaprylin
|
|---|---|---|---|---|---|---|---|
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Plasma Acetoacetate/Beta-hydroxybutyrate Ratio
|
7.7 Ratio
Standard Deviation 3.2
|
6.9 Ratio
Standard Deviation 1.5
|
7.7 Ratio
Standard Deviation 1.1
|
5.9 Ratio
Standard Deviation 1.0
|
9.5 Ratio
Standard Deviation 2.9
|
8.4 Ratio
Standard Deviation 1.3
|
8.1 Ratio
Standard Deviation 2.2
|
Adverse Events
Supplementation
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place