Neoadjuvant mFolfirinox With or Without Preoperative Concomitant Chemoradiotherapy in Patients With Borderline Resectable Pancreatic Carcinoma (PANDAS-PRODIGE 44)

NCT ID: NCT02676349

Last Updated: 2023-09-28

Basic Information

• Recruitment Status: ACTIVE_NOT_RECRUITING
• Clinical Phase: PHASE2
• Total Enrollment: 130 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-10-13
• Study Completion Date: 2027-10-31

Brief Summary

This is a prospective, randomized phase II trial. The aim of this study is to assess the efficacy of two therapeutics strategies. Patients with borderline-resectable pancreatic cancer (BRPC) will be randomly in two arms : neoadjuvant mFolfirinox followed with or without preoperative chemoradiotherapy with capecitabine.

Detailed Description

Surgery, especially if followed by adjuvant chemotherapy, offers the only chance of cure of pancreatic cancer. At first diagnosis, after careful assessment, only 10 to 15% of patients are considered to be candidates for surgical resection and about 7% have a potentially resectable disease. These potentially resectable tumors called "borderline resectable pancreatic cancer" (BRPC) are conceptualized as those that involve the mesenteric vasculature to a limited extent and those for which resection, while possible, would likely be compromised by positive surgical margins (R1) in the absence of neoadjuvant treatment. R0 resection is indeed considered as an independent prognostic factor for survival when the surgical procedures, histological examination and definition of microscopic invasion are standardized.

The objectives of neoadjuvant treatments of BRPC is to reduce tumor volume before surgery in order to improve the chances of radical (R0) resection and to reduce the rate of lymph node positivity and recurrences. The primary outcome in published studies is usually R0 resection rate, but these results also depend on the number of margins examined and the definition of microscopic margin involvement. Prospective studies with consistent selection criteria and standardized assessment criteria are needed.

Different neoadjuvant therapeutic strategies have been tested in pilot studies: preoperative chemoradiotherapy or neoadjuvant chemotherapy, followed or not by a preoperative (chemo)radiotherapy. Due to the lack of randomized studies, the best sequence of treatment administration has not been established.

The aim of this prospective, randomized, multicenter, trial is to evaluate the R0 resection rate with neoadjuvant Folfirinox, followed or not by radiochemotherapy for patients with borderline resectable pancreatic cancers.

Conditions

Pancreatic Carcinoma

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Arm B

Neoadjuvant chemotherapy with mFolfirinox regimen + concomitant chemoradiotherapy + surgery + adjuvant chemotherapy

Group Type: EXPERIMENTAL

mFolfirinox

Intervention Type: DRUG

oxaliplatin folinic acid irinotecan 5FU oxaliplatin

Chemoradiotherapy

Intervention Type: RADIATION

conformational external irradiation (50.4 Gy) + capecitabine

surgery

Intervention Type: PROCEDURE

1 to 4 weeks after neoadjuvant treatment according to tumour response

Adjuvant chemotherapy

Intervention Type: DRUG

Gemcitabine or modified LV5FU (folinic acid+-bolus fluorouracil+ infusional fluorouracil)

Arm A

Neoadjuvant chemotherapy with mFolfirinox regimen + surgery + adjuvant chemotherapy

Group Type: ACTIVE_COMPARATOR

mFolfirinox

Intervention Type: DRUG

oxaliplatin folinic acid irinotecan 5FU oxaliplatin

surgery

Intervention Type: PROCEDURE

1 to 4 weeks after neoadjuvant treatment according to tumour response

Adjuvant chemotherapy

Intervention Type: DRUG

Gemcitabine or modified LV5FU (folinic acid+-bolus fluorouracil+ infusional fluorouracil)

Interventions

mFolfirinox

oxaliplatin folinic acid irinotecan 5FU oxaliplatin

Intervention Type: DRUG

Chemoradiotherapy

conformational external irradiation (50.4 Gy) + capecitabine

Intervention Type: RADIATION

surgery

1 to 4 weeks after neoadjuvant treatment according to tumour response

Intervention Type: PROCEDURE

Adjuvant chemotherapy

Gemcitabine or modified LV5FU (folinic acid+-bolus fluorouracil+ infusional fluorouracil)

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• ECOG performance status 0 or 1
• Adult patients ≥ 18 years and ≤ 75 years of age
• Histologic or cytologic proven adenocarcinoma of the pancreas (histologic confirmation of diagnosis is preferred)
• Confirmation by independent multidisciplinary expert review of borderline resectable status, according to NCCN-Clinical Practice Guidelines in Oncology "pancreatic adenocarcinoma", version 1.2015.
• Adequate hematologic function, as follows:
• absolute neutrophil count (ANC) ≥ > 2000/mm3
• platelet count ≥ 100 000/mm3
• haemoglobin ≥ 10 g/dL
• Adequate renal, hepatic and bone marrow function, defined as:

• Calculated creatinine clearance ≥ 50 mL/min according to MDRD formula
• Serum total bilirubin ≤ 1.5 times the institutional upper limit of normal. Patients with a biliary short metal stent due to cancer obstruction may be included provided that high-quality imaging is performed before stenting and bilirubin level after stent insertion decreased to ≤ 20 mg/L (≤ 34 µmol/l), and there is no cholangitis.
• Male and female subjects who agree to use highly effective methods of birth control (e.g., condoms, combined oral contraceptives, some intrauterine devices [IUDs], sexual abstinence, or sterilized partner)

• for male subject: during the treatment and for up to 6 months after the last dose of oxaliplatin or up to 3 months after the last dose of irinotcan.
• for female subject: during the treatment and for up to 4 months after the last dose of oxaliplatin or up to 3 months after the last dose of irinotcan.
• Ability to provide written informed consent before the start of any study specific procedures
• Patient's legal capacity to consent to study participation and to understand and comply with the requirements of the study.

Exclusion Criteria

• Any previous treatment of the pancreatic cancer except biliary short metal stenting (chemotherapy, targeted tumor therapy, local ablative therapy, previous irradiation within the actual fields of planned radiotherapy)
• Evidence of distant metastases including ascites
• Evidence of extent of pancreatic cancer beyond that defined as "borderline resectable" : suspicious lymphadenopathy outside of the standard field of resection (i.e., aortocaval nodes, distant abdominal nodes)
• Contraindication for pancreas resection
• Pregnant or breast feeding females
• Patients with known Gilbert's Syndrome or homozygosity for UGT1A1*28 polymorphism
• Uracilemia ≥ 16ng/mL either a partial or complete deficiency in dihydropyrimidine dehydrogenase (DPD)
• Participation in any other clinical trial or treatment with any experimental drug within 28 days before enrolment to the study or during study participation until the end of treatment visit that can be interfering with the objectives of the study
• Previous or concurrent malignant tumor disease other than underlying tumor disease (with the exception of cervical cancer in situ, adequately treated non-melanoma skin cancers, superficial bladder tumors (Ta, Tis, and T1) or any curatively treated without chemotherapy and favourable prognosis tumors without evidence of disease for > 3 years prior to enrolment)
• Any severe and/or uncontrolled medical conditions including but not limited to:

• Clinically significant cardiovascular or vascular disease : angina pectoris (even controlled), previous myocardial infarction, serious uncontrolled cardiac arrhythmia, chronic heart failure, acute or chronic infectious disease requiring general treatment)
• Acute and chronic, active infectious disorders that requires systemic treatment
• Peripheral polyneuropathy > grade 1
• Any previous inflammatory disease of colon or rectum
• Any other severe concomitant disease or disorder, which could influence patient's ability to participate in the study and his/her safety during the study e.g. severe hepatic, renal, pulmonary, metabolic, or psychiatric disorders
• Uncorrected disturbed electrolyte balance, in particular hypokalemia or hypocalcemia
• Hypersensitivity against any of the study drugs (gemcitabine, oxaliplatin, irinotecan, 5-fluorouracil, folinic acid), or the ingredients of these drugs (e.g. fructose).

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Institut de Cancérologie de Lorraine

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Thierry CONROY, Pr

Role: PRINCIPAL_INVESTIGATOR

Institut de Cancérologie de Lorraine

Jean-Baptiste BACHET, Pr

Role: STUDY_CHAIR

Groupe Hospitalier Pitié-Salpêtrière

Pascal HAMMEL, Pr

Role: STUDY_CHAIR

Hôpital Paul Brousse - Hôpitaux de Paris (AP-HP)

Locations

Institut Bergonié

Bordeaux, , France

Polyclinique Bordeaux Nord

Bordeaux, , France

Hôpital Beaujon

Clichy, , France

Chu Colmar

Colmar, , France

Hôpital Henri Mondor (APHP)

Créteil, , France

Centre Oscar Lambret

Lille, , France

Chru Lille

Lille, , France

Infirmerie Protestante de Lyon

Lyon, , France

Hôpital Européen Marseille

Marseille, , France

Hôpital La Timone

Marseille, , France

Institut Paoli CALMETTES

Marseille, , France

Institut du Cancer de Montpellier

Montpellier, , France

Chu Nantes

Nantes, , France

Hôpital Cochin (APHP)

Paris, , France

Institut Mutualiste Montsouris

Paris, , France

Pitié Salpêtrière (APHP)

Paris, , France

Hôpital Haut-Lévêque

Pessac, , France

CHU Reims

Reims, , France

Centre Eugène Marquis

Rennes, , France

Chu Rouen

Rouen, , France

CHP Saint Grégoire

Saint-Grégoire, , France

Institut de Cancérologie de l'Ouest

Saint-Herblain, , France

Chru Tours

Tours, , France

Chru Nancy

Vandœuvre-lès-Nancy, , France

Institut de Cancérologie de Lorraine

Vandœuvre-lès-Nancy, , France

Hôpital Paul Brousse

Villejuif, , France

Countries

France

Other Identifiers

2014-005681-29

Identifier Type: -

Identifier Source: org_study_id